Population Pharmacokinetics of Tenofovir and Tenofovir-diphosphate in healthy women.
This article is protected by copyright. All rights reserved.
PMID: 25581815 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - January 8, 2015 Category: Drugs & Pharmacology Authors: Burns RN, Hendrix CW, Chaturvedula A Tags: J Clin Pharmacol Source Type: research
Comparison of Visual and Ultraviolet Light Inspection Versus DNA/Protein Biomarkers to Assess Product Adherence With Vaginal Microbicide Applicators
ConclusionsDNA and protein-based biomarkers offer significantly higher sensitivity and specificity compared with VIRA and UVL assessment. The accuracy of these objective biomarkers is maintained despite storage of returned products for approximately 30 days and under conditions potentially modeling field use. (Source: Sexually Transmitted Diseases)
Source: Sexually Transmitted Diseases - November 14, 2014 Category: Sexual Medicine Tags: Original Study Source Type: research
The effects of hyaluronic acid vaginal gel on the vaginal epithelium of ovariectomized rats
Gynecological Endocrinology, Ahead of Print. (Source: Gynecological Endocrinology)
Source: Gynecological Endocrinology - November 4, 2014 Category: Endocrinology Tags: article Source Type: research
Effect of Vitamin E on the Vaginal Atrophy of Postmenopausal Women
Vaginal atrophy is a silent epidemic that affects up to 50%-60% of postmenopausal women. Local,low-dose estrogen preparations are considered first-line pharmacologic treatment. For women concerned about hormone use a number of over-the-counter (OTC) vaginal moisturizer and lubricant products are considered first-line nonhormonal treatments. It has been reported that vitamin E vaginal gel improved the symptoms of volvovaginal atrophy However, oral vitamin E has never been well tested in a randomized clinical trial for efficacy against vaginal atrophy. (Source: Value in Health)
Source: Value in Health - November 1, 2014 Category: Global & Universal Authors: M. Zareai Source Type: research
Tenofovir gel for HIV prevention for women: Perspectives of Key Opinion Leaders from India
Conclusions As new HIV-prevention technologies advance through clinical trials, there is a concomitant necessity to engage in policy analysis exercises. Formative research with stakeholders early in the process is an important yet often overlooked step. The potential role that the tenofovir gel could play in India will depend in large part on epidemiological, public health, and economic factors. Understanding target populations' perspectives on the product will also be critical for its successful introduction. (Source: Health Policy and Technology)
Source: Health Policy and Technology - October 12, 2014 Category: Health Management Source Type: research
Progesterone replacement with vaginal gel versus i.m. injection: cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts
This study is limited by its retrospective design and by its lack of randomization to the type of luteal support. In addition, because no a priori expected rates of success could be provided for this retrospective investigation, it was not possible to estimate statistical power associated with the various outcomes presented.
WIDER IMPLICATIONS OF THE FINDINGS
With the recent trends toward single embryo transfer (SET) and use of vitrified blastocysts in FET cycles, our data with ~40% of cycles being SET and use of exclusively vitrified blastocysts are more relevant to current practices than previous studies.
STUDY FUNDING...
Source: Human Reproduction - July 10, 2014 Category: Reproduction Medicine Authors: Shapiro, D. B., Pappadakis, J. A., Ellsworth, N. M., Hait, H. I., Nagy, Z. P. Tags: Infertility Source Type: research
Effects of () soy isoflavone vaginal gel on epithelium morphology and estrogen receptor expression in postmenopausal women: A 12-week, randomized, double-blind, placebo-controlled trial
(Source: Maturitas)
Source: Maturitas - May 6, 2014 Category: Primary Care Authors: Sônia Maria Rolim Rosa Lima, Bianca Franco Augusto Bernardo, Silvia Saito Yamada, Benedito Fabiano Reis, Gustavo Maximiliano Dutra da Silva, Maria Antonieta Longo Galvão Source Type: research
Formulation Development and Evaluation of Innovative Two-Polymer (SR-2P) Bioadhesive Vaginal Gel.
Abstract
The main objective of this investigation was to study the feasibility of developing a vaginal bioadhesive microbicide using a SRI's proprietary two-polymer gel platform (SR-2P). Several formulations were prepared with different combinations of temperature-sensitive polymer (Pluronic® F-127) and mucoadhesive polymer (Noveon® AA-1), producing gels of different characteristics. Prototype polymeric gels were evaluated for pH, osmolality, buffering capacity, and viscosity under simulated vaginal semen dilutions, and bioadhesivity using ex vivo mini pig vaginal tissues and texture analyzer. The pH of ...
Source: AAPS PharmSciTech - April 30, 2014 Category: Drugs & Pharmacology Authors: Podaralla S, Alt C, Shankar GN Tags: AAPS PharmSciTech Source Type: research
User-Identified Gel Characteristics: A Qualitative Exploration of Perceived Product Efficacy of Topical Vaginal Microbicides.
Abstract
Research has demonstrated that certain vaginal gel products-microbicides containing antiretroviral drugs-may reduce HIV infection risk among women. But for vaginal gels to avert HIV and other sexually transmitted infections (STIs), at-risk women must be willing to use them as directed. These products must therefore be "acceptable" to women and an important component of acceptability is users' perception that the product will work to prevent infection. We sought to understand how women's perceptions of vaginal gel properties may shape their understanding of product efficacy for HIV and STI preventi...
Source: Archives of Sexual Behavior - January 23, 2014 Category: Psychiatry & Psychology Authors: Morrow KM, Underhill K, van den Berg JJ, Vargas S, Rosen RK, Katz DF Tags: Arch Sex Behav Source Type: research
[Survey on cervical ripening practices in France.]
CONCLUSION: Numbers of methods of cervical ripening and protocols of administration and surveillance varied widely between obstetrical departments, sometimes even in contradiction to guidelines and review of the litterature. Controlled-released pessary and intra-vaginal gel of dinoprostone were the most common molecules used for cervical ripening. Differences in protocols should be analyzed on their efficiency to establish consensus-based recommendations.
PMID: 24411337 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique et Fertilite)
Source: Gynecologie, Obstetrique et Fertilite - January 7, 2014 Category: OBGYN Authors: Bel S, Gaudineau A, Zorgnotti L, Sananes N, Fritz G, Langer B Tags: Gynecol Obstet Fertil Source Type: research
Designing Preclinical Perceptibility Measures to Evaluate Topical Vaginal Gel Formulations: Relating User Sensory Perceptions and Experiences to Formulation Properties
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Source: AIDS Research and Human Retroviruses - December 9, 2013 Category: Infectious Diseases Tags: article Source Type: research
Development and in vitro evaluation of a vaginal microbicide gel formulation for UAMC01398, a novel diaryltriazine NNRTI against HIV-1.
Abstract
Diaryltriazines (DATAs) constitute a class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) that are being investigated for use as anti-HIV microbicides. The aim of the present study was (1) to assess the biopharmaceutical properties of the DATA series, (2) to select the lead candidate as vaginal microbicide and (3) to develop and evaluate gel formulations of the lead candidate. First, the vaginal tissue permeation potential of the different DATAs was screened by performing permeability and solubility measurements. To obtain a suitable formulation of the lead microbicide candidate, seve...
Source: Antiviral Research - November 20, 2013 Category: Virology Authors: Grammen C, Ariën KK, Venkatraj M, Joossens J, Veken PV, Heeres J, Lewi PJ, Haenen S, Augustyns K, Vanham G, Augustijns P, Brouwers J Tags: Antiviral Res Source Type: research
Assessment of topical microbicides to prevention HIV-1 transmission: concepts, testing, lessons learned.
Abstract
The development of topically applied products capable of preventing vaginal and rectal transmission of HIV-1 has been on-going for nearly 20 years. Despite this, only one clinical trial has demonstrated protection against sexual transmission of HIV-1 in women. This review covers the development of microbicides, also referred to as topical pre-exposure prophylaxis (PrEP), through three stages. The first stage focused on nonspecific agents, including surfactants such as nonoxynol-9 (N-9), to prevent HIV-1 transmission. Unfortunately, N-9 enhanced susceptibility to sexual transmission of HIV-1 when e...
Source: Antiviral Research - July 8, 2013 Category: Virology Authors: David Friend R, Kiser PF Tags: Antiviral Res Source Type: research
