P41 Impact of product adherence and condom use on rates of urogenital re-infection with chlamydia trachomatis or neisseria gonorrhoeae in the amprevence phase 2B/3 clinical trial

The objectives of this analysis were to assess the effects of adherence and condom use during the phase 2b/3 AMPREVENCE study on urogenital re-infection with Chlamydia trachomatis (CT) or Neisseria gonorrhoeae (GC).
Source: Contraception - Category: OBGYN Authors: Source Type: research

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Publication date: Available online 8 October 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Atinuke O. Olaleye, Ochuwa A. Babah, Chioma S. Osuagwu, Folasade T. Ogunsola, Bosede B. Afolabi
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Discussion Syphilis is caused by the spirochete Treponema pallidum. It is a very old disease that despite understanding the organism and readily available treatment, still causes disease. Syphilis is transmitted sexually. According to the Centers for Disease Control, “[i]n 2018, a total of 35,063 cases of [Primary and Secondary] syphilis were reported in the United States, yielding a rate of 10.8 cases per 100,000 population …. This rate represents a 14.9% increase compared with 2017 (9.4 cases per 100,000 population), and a 71.4% increase compared with 2014 (6.3 cases per 100,000 population).” The incre...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
The sexually transmitted infections (STIs) chlamydia (CT) and gonorrhea (NG) are often asymptomatic in women and undetected by syndromic management, leading to complications such as pelvic inflammatory disease, infertility, and ectopic pregnancy. Molecular testing, such as the GeneXpert CT/NG assay, is highly sensitive, but cost restraints preclude implementation of these technologies in resource-limited settings. Pooled testing is one strategy to reduce the cost per sample, but the extent of savings depends on disease prevalence. The current study describes a pooling strategy based on identification of sociodemographic an...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Bacteriology Source Type: research
ConclusionsWith no alternative antimicrobial treatment options for gonorrhoea and only a few new drugs in the development pipeline, it is necessary to monitor drug resistance and optimize treatment regimens regularly. Moreover, investigations for novel drugs should be wired.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
Conclusions We describe a 24% curable STI prevalence among women at risk for HIV exposure who were planning for pregnancy. These data highlight the importance of integrating laboratory-based STI screening into safer conception programs to maximize the health of HIV-affected women, children, and families.
Source: Sexually Transmitted Diseases - Category: Sexual Medicine Tags: Notes Source Type: research
Conclusions C. trachomatis infection during pregnancy is associated with increased odds of wheezing, asthma and impaired lung function. The causality of the observed associations and potential underlying mechanisms need to be explored.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric pulmonology Original Articles: Paediatrics Source Type: research
Conclusion: Cervico-vaginitis is very common in our setting. Screening for genital tract mycoplasmas should be the first to be requested to women with cervico-vaginitis.
Source: Indian Journal of Sexually Transmitted Diseases - Category: Infectious Diseases Authors: Source Type: research
Background We evaluated the clinical management and risk factors for Trichomonas vaginalis–positive adolescents in upstate South Carolina. Methods An Epic electronic medical record report was generated to identify any physician-ordered T. vaginalis test from February 2016 to December 2017 for patients aged 12 to 18 years within the Prisma Health Upstate system. Utilizing a case-control study design of patients with a documented T. vaginalis diagnostic result, we reviewed records of patients with physician-ordered T. vaginalis tests for demographics, clinical disease course, sexually transmitted infection test re...
Source: Sexually Transmitted Diseases - Category: Sexual Medicine Tags: Original Studies Source Type: research
This study identifies the putative vaccine candidates that are membrane bound with high antigenicity properties; antigenicity induces the immunogenicity which involves identification of T-cell and B-cell epitopes that induce both humoral and cell-mediated immunity. The epitopes ‘LSWEMELAY’, ‘LSNTEGYRY’, ‘TSDLGQMEY’, ‘FIDLLQAIY’ and ‘FSNNFSDIY’ were predicted as core sequences for class I MHC molecules. The identified epitopes showed promising ability to interact with the human leukocyte antigens (HLA). These epitopes showed maximum population coverage w ith epitop...
Source: Network Modeling Analysis in Health Informatics and Bioinformatics - Category: Bioinformatics Source Type: research
Authors: D'Aiuto C, Valderrama A, Byrns M, Boucoiran I Abstract OBJECTIVES: To analyze risk factors for the presence of sexually transmitted and blood-borne infections (STBBIs) in pregnancy and to determine whether pregnant women with STBBIs are more likely to experience adverse pregnancy outcomes. METHODS: This retrospective cohort study involved analyzing the electronic records of 3460 pregnant women followed at Sainte-Justine Hospital in Montréal, Québec, between March 2017 and January 2019. An outcome is defined as a pregnancy where the woman has at least one positive laboratory result for chl...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
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