Cancers, Vol. 15, Pages 5225: Carbonic Anhydrase Inhibitors Induce Ferroptosis through Inhibition of AKT/FTH1 Signaling in Ewing Sarcoma Tumor Cells
roeder
Ilya V. Ulasov
Ewing sarcoma (ES) is one of the most frequent types of malignant tumors among children. The active metabolic state of ES cells presents a new potential target for therapeutic interventions. As a primary regulator of cellular homeostasis, carbonic anhydrases (CAs; EC 4.2.1.1) have emerged as promising molecular targets for the development of anticancer drugs. Within the present study, we tested the commercial drug acetazolamide and our previously discovered inhibitors to target the CAII isoform, which was overexpressed and positively correlated with ES patient relapse. We employed molecular biol...
Source: Cancers - October 31, 2023 Category: Cancer & Oncology Authors: Darya Fayzullina Semyn Yakushov Kamilla Kantserova Elizaveta Belyaeva Denis Aniskin Sergey Tsibulnikov Nafisa Fayzullina Stanislav Kalinin Olga Romantsova Peter S. Timashev Brett A. Schroeder Ilya V. Ulasov Tags: Article Source Type: research
Diffuse cerebral edema with leukoencephalopathy revealing systemic lupus erythematosus: A case report and review of literature
Conclusions: We highlight, through this case report and the literature review, the importance of considering SLE in patients with cerebral edema and diffuse leukoencephalopathy and treating it aggressively.PMID:37887528 | DOI:10.1177/09612033231207723 (Source: Lupus)
Source: Lupus - October 27, 2023 Category: Rheumatology Authors: Rania Zouari Mohamed Zakaria Saeid Mahmoud Marzouk Amine Rachdi Samia Ben Sassi Source Type: research
Diffuse cerebral edema with leukoencephalopathy revealing systemic lupus erythematosus: A case report and review of literature
Conclusions: We highlight, through this case report and the literature review, the importance of considering SLE in patients with cerebral edema and diffuse leukoencephalopathy and treating it aggressively.PMID:37887528 | DOI:10.1177/09612033231207723 (Source: Lupus)
Source: Lupus - October 27, 2023 Category: Rheumatology Authors: Rania Zouari Mohamed Zakaria Saeid Mahmoud Marzouk Amine Rachdi Samia Ben Sassi Source Type: research
Diffuse cerebral edema with leukoencephalopathy revealing systemic lupus erythematosus: A case report and review of literature
Conclusions: We highlight, through this case report and the literature review, the importance of considering SLE in patients with cerebral edema and diffuse leukoencephalopathy and treating it aggressively.PMID:37887528 | DOI:10.1177/09612033231207723 (Source: Lupus)
Source: Lupus - October 27, 2023 Category: Rheumatology Authors: Rania Zouari Mohamed Zakaria Saeid Mahmoud Marzouk Amine Rachdi Samia Ben Sassi Source Type: research
Diffuse cerebral edema with leukoencephalopathy revealing systemic lupus erythematosus: A case report and review of literature
Conclusions: We highlight, through this case report and the literature review, the importance of considering SLE in patients with cerebral edema and diffuse leukoencephalopathy and treating it aggressively.PMID:37887528 | DOI:10.1177/09612033231207723 (Source: Lupus)
Source: Lupus - October 27, 2023 Category: Rheumatology Authors: Rania Zouari Mohamed Zakaria Saeid Mahmoud Marzouk Amine Rachdi Samia Ben Sassi Source Type: research
RCT Abstract - Acetazolamide to prevent impending altitude-related adverse health effects in COPD patients. RCT
Conclusion: In lowlanders with COPD, travelling to 3100m, SSM-guided preventive acetazolamide therapy reduced the incidence of ARAHE. This novel approach may allow to restrict the use of preventive acetazolamide therapy to patients at risk. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Furian, M., Reiser, A., Mademilov, M., Bitos, K., Buenzli, S., Abdraeva, A., Champigneulle, B., Carta, A., Bauer, M., Ulrich, T., Mueller, J., Grimm, M., Schneider, S., Shakiev, N., Taalaibekova, A., Ozonova, A., Magdieva, K., Mirzalieva, G., Akylbekov, A Tags: Clinical and epidemiological respiratory sleep medicine Source Type: research
Cortical oxygen extraction fraction using quantitative BOLD MRI and cerebral blood flow during vasodilation
Conclusion: Quantitative BOLD modeling can reliably measure OEF across multiple physiological conditions and captures vascular changes with higher sensitivity than R2’ values. The inverse correlation between OEF and CBF across regions in DMN, suggests that these two measurements, in response to ACZ vasodilation, are reliable indicators of tissue health in this healthy cohort. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - October 6, 2023 Category: Physiology Source Type: research
Effects of carbonic anhydrase activity on the excitability of hippocampal axons during high-frequency firing
Brain Res. 2023 Sep 23:148604. doi: 10.1016/j.brainres.2023.148604. Online ahead of print.ABSTRACTEpileptic activity is known to cause a lowering of intraneuronal pH, which has been suggested to serve as a feedback signal to terminate seizures. The mechanism of such signaling is unclear, but likely involves an altered function of several types of ligand- and voltage-gated channels in postsynaptic membranes caused by increasing cytosolic and extracellular [H+]. In addition, axonal conduction properties may be altered by endogenous pH signals, but this has not been investigated. In the present study, we have recorded the axo...
Source: Brain Research - September 25, 2023 Category: Neurology Authors: Mogens Andreasen Steen Nedergaard Source Type: research
Effects of carbonic anhydrase activity on the excitability of hippocampal axons during high-frequency firing
Brain Res. 2023 Sep 23:148604. doi: 10.1016/j.brainres.2023.148604. Online ahead of print.ABSTRACTEpileptic activity is known to cause a lowering of intraneuronal pH, which has been suggested to serve as a feedback signal to terminate seizures. The mechanism of such signaling is unclear, but likely involves an altered function of several types of ligand- and voltage-gated channels in postsynaptic membranes caused by increasing cytosolic and extracellular [H+]. In addition, axonal conduction properties may be altered by endogenous pH signals, but this has not been investigated. In the present study, we have recorded the axo...
Source: Biomed Res - September 25, 2023 Category: Research Authors: Mogens Andreasen Steen Nedergaard Source Type: research
Exploring novel anticancer pyrazole benzenesulfonamides featuring tail approach strategy as carbonic anhydrase inhibitors
This study aimed to design potent carbonic anhydrase inhibitors (CAIs) based on pyrazole benzenesulfonamide core. Nine series of substituted pyrazole benzenesulfonamide compounds were synthesized with variable groups like sulphamoyl group as in compounds 4a-e, its bioisosteric carboxylic acid as in compounds 5a-e and 8e, ethyl carboxylate ester as in compounds 6a-e and 9a-e, which were designed as potential prodrugs, isothiazole ring as in compound 7, hydrazide derivative 10e, hydroxamic acid derivatives 11a-e and semicarbazide derivatives 12a-c,e. All the synthesized compounds were investigated for their carbonic anhydras...
Source: European Journal of Medicinal Chemistry - September 25, 2023 Category: Chemistry Authors: Rehab F Ahmed Walaa R Mahmoud Nagwa M Abdelgawad Marwa A Fouad Mona F Said Source Type: research
Para-toluenesulfonamide, a novel potent carbonic anhydrase inhibitor, improves hypoxia-induced metastatic breast cancer cell viability and prevents resistance to αPD-1 therapy in triple-negative breast cancer
This study aimed to investigate the involvement of CA9 in the anti-tumor activity of para-toluenesulfonamide (PTS) and elucidate its mechanism of action against breast cancer both in vitro and in vivo. MCF-7 and MDA-MB-231 breast cancer cells were treated with PTS or subjected to hypoxic conditions using cobalt chloride (CoCl2), with acetazolamide serving as a positive control. Additionally, 4T1 breast cancer cell allograft mice were co-treated with PTS and α-programmed cell death 1 (αPD-1) monoclonal antibody for one month. The results demonstrated that PTS effectively reduced cell viability and reversed migration abili...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2023 Category: Drugs & Pharmacology Authors: Hsin-Yuan Chen Chia-En Lin Shun-Chi Wu Zong-Yu Yang Yi-Fen Chiang Ko-Chieh Huang Kai-Lee Wang Mohamed Ali Tzong-Ming Shieh Hsin-Yi Chang Tsui-Chin Huang Shih-Min Hsia Source Type: research
Effects of carbonic anhydrase activity on the excitability of hippocampal axons during high-frequency firing
Brain Res. 2023 Sep 23:148604. doi: 10.1016/j.brainres.2023.148604. Online ahead of print.ABSTRACTEpileptic activity is known to cause a lowering of intraneuronal pH, which has been suggested to serve as a feedback signal to terminate seizures. The mechanism of such signaling is unclear, but likely involves an altered function of several types of ligand- and voltage-gated channels in postsynaptic membranes caused by increasing cytosolic and extracellular [H+]. In addition, axonal conduction properties may be altered by endogenous pH signals, but this has not been investigated. In the present study, we have recorded the axo...
Source: Brain Research - September 25, 2023 Category: Neurology Authors: Mogens Andreasen Steen Nedergaard Source Type: research
Exploring novel anticancer pyrazole benzenesulfonamides featuring tail approach strategy as carbonic anhydrase inhibitors
This study aimed to design potent carbonic anhydrase inhibitors (CAIs) based on pyrazole benzenesulfonamide core. Nine series of substituted pyrazole benzenesulfonamide compounds were synthesized with variable groups like sulphamoyl group as in compounds 4a-e, its bioisosteric carboxylic acid as in compounds 5a-e and 8e, ethyl carboxylate ester as in compounds 6a-e and 9a-e, which were designed as potential prodrugs, isothiazole ring as in compound 7, hydrazide derivative 10e, hydroxamic acid derivatives 11a-e and semicarbazide derivatives 12a-c,e. All the synthesized compounds were investigated for their carbonic anhydras...
Source: European Journal of Medicinal Chemistry - September 25, 2023 Category: Chemistry Authors: Rehab F Ahmed Walaa R Mahmoud Nagwa M Abdelgawad Marwa A Fouad Mona F Said Source Type: research
Exploring novel anticancer pyrazole benzenesulfonamides featuring tail approach strategy as carbonic anhydrase inhibitors
This study aimed to design potent carbonic anhydrase inhibitors (CAIs) based on pyrazole benzenesulfonamide core. Nine series of substituted pyrazole benzenesulfonamide compounds were synthesized with variable groups like sulphamoyl group as in compounds 4a-e, its bioisosteric carboxylic acid as in compounds 5a-e and 8e, ethyl carboxylate ester as in compounds 6a-e and 9a-e, which were designed as potential prodrugs, isothiazole ring as in compound 7, hydrazide derivative 10e, hydroxamic acid derivatives 11a-e and semicarbazide derivatives 12a-c,e. All the synthesized compounds were investigated for their carbonic anhydras...
Source: European Journal of Medicinal Chemistry - September 25, 2023 Category: Chemistry Authors: Rehab F Ahmed Walaa R Mahmoud Nagwa M Abdelgawad Marwa A Fouad Mona F Said Source Type: research
Acetazolamide for metabolic alkalosis complicating respiratory failure with chronic obstructive pulmonary disease or obesity hypoventilation syndrome: a systematic review
Conclusion
Acetazolamide may have little impact on respiratory failure with metabolic alkalosis in patients with chronic respiratory diseases. However, clinically significant benefits or harms are unable to be excluded, and larger trials are required.
PROSPERO registration number
CRD42021278757. (Source: Thorax)
Source: Thorax - September 15, 2023 Category: Respiratory Medicine Authors: Bemand, T. J., Chatoor, R., Natale, P., Strippoli, G., Delaney, A. Tags: Thorax Critical care Source Type: research
