Spontaneous rhinorrhea and idiopathic intracranial hypertension: a complex and challenging association
CONCLUSIONS: The complex relationship between spontaneous CSF leaks and IIH is a challenge that benefits from multidisciplinary evaluation and management for successful treatment. Treatments such as endoscopic repair, acetazolamide, and VP/ /LP shunts reduce complications and recurrence. Personalised plans addressing elevated intracranial pressure are crucial for successful outcomes.PMID:38393958 | DOI:10.5603/pjnns.98054 (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - February 23, 2024 Category: Neurology Authors: Leonardo de Macedo Filho Carolina Carmona Pinheiro Machado Gabrielle Brito Bezerra Mendes Luma Maria Figueiredo Santana Mauro Emiliano Ruella Sanjeet Grewal Kaisorn L Chaichana Alfredo Quinones Hinojosa Olga Fermo Joao Paulo Almeida Source Type: research
Spontaneous rhinorrhea and idiopathic intracranial hypertension: a complex and challenging association
CONCLUSIONS: The complex relationship between spontaneous CSF leaks and IIH is a challenge that benefits from multidisciplinary evaluation and management for successful treatment. Treatments such as endoscopic repair, acetazolamide, and VP/ /LP shunts reduce complications and recurrence. Personalised plans addressing elevated intracranial pressure are crucial for successful outcomes.PMID:38393958 | DOI:10.5603/pjnns.98054 (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - February 23, 2024 Category: Neurology Authors: Leonardo de Macedo Filho Carolina Carmona Pinheiro Machado Gabrielle Brito Bezerra Mendes Luma Maria Figueiredo Santana Mauro Emiliano Ruella Sanjeet Grewal Kaisorn L Chaichana Alfredo Quinones Hinojosa Olga Fermo Joao Paulo Almeida Source Type: research
Spontaneous rhinorrhea and idiopathic intracranial hypertension: a complex and challenging association
CONCLUSIONS: The complex relationship between spontaneous CSF leaks and IIH is a challenge that benefits from multidisciplinary evaluation and management for successful treatment. Treatments such as endoscopic repair, acetazolamide, and VP/ /LP shunts reduce complications and recurrence. Personalised plans addressing elevated intracranial pressure are crucial for successful outcomes.PMID:38393958 | DOI:10.5603/pjnns.98054 (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - February 23, 2024 Category: Neurology Authors: Leonardo de Macedo Filho Carolina Carmona Pinheiro Machado Gabrielle Brito Bezerra Mendes Luma Maria Figueiredo Santana Mauro Emiliano Ruella Sanjeet Grewal Kaisorn L Chaichana Alfredo Quinones Hinojosa Olga Fermo Joao Paulo Almeida Source Type: research
Spontaneous rhinorrhea and idiopathic intracranial hypertension: a complex and challenging association
CONCLUSIONS: The complex relationship between spontaneous CSF leaks and IIH is a challenge that benefits from multidisciplinary evaluation and management for successful treatment. Treatments such as endoscopic repair, acetazolamide, and VP/ /LP shunts reduce complications and recurrence. Personalised plans addressing elevated intracranial pressure are crucial for successful outcomes.PMID:38393958 | DOI:10.5603/pjnns.98054 (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - February 23, 2024 Category: Neurology Authors: Leonardo de Macedo Filho Carolina Carmona Pinheiro Machado Gabrielle Brito Bezerra Mendes Luma Maria Figueiredo Santana Mauro Emiliano Ruella Sanjeet Grewal Kaisorn L Chaichana Alfredo Quinones Hinojosa Olga Fermo Joao Paulo Almeida Source Type: research
Spontaneous rhinorrhea and idiopathic intracranial hypertension: a complex and challenging association
CONCLUSIONS: The complex relationship between spontaneous CSF leaks and IIH is a challenge that benefits from multidisciplinary evaluation and management for successful treatment. Treatments such as endoscopic repair, acetazolamide, and VP/ /LP shunts reduce complications and recurrence. Personalised plans addressing elevated intracranial pressure are crucial for successful outcomes.PMID:38393958 | DOI:10.5603/pjnns.98054 (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - February 23, 2024 Category: Neurology Authors: Leonardo de Macedo Filho Carolina Carmona Pinheiro Machado Gabrielle Brito Bezerra Mendes Luma Maria Figueiredo Santana Mauro Emiliano Ruella Sanjeet Grewal Kaisorn L Chaichana Alfredo Quinones Hinojosa Olga Fermo Joao Paulo Almeida Source Type: research
Tachyphylactic Effects after Long-term Use of Systemic Acetazolamide
Klin Monbl Augenheilkd. 2024 Feb 22. doi: 10.1055/a-2211-9506. Online ahead of print.NO ABSTRACTPMID:38387484 | DOI:10.1055/a-2211-9506 (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - February 22, 2024 Category: Opthalmology Authors: Katrin Marie Engesser Dominique Pr ètot Torsten Schlote Maria Della Volpe Waizel Source Type: research
Impact of weight reduction on structural and functional parameters of the optic nerve in idiopathic intracranial hypertension
CONCLUSION: Reduction in BMI had a significant impact on both structural and functional parameters of the optic nerve in IIH. The involvement of a well-certified dietician should be an integral part of treatment in IIH.PMID:38380874 | DOI:10.1177/11206721241232038 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Mousumi Banerjee Swati Phuljhele Rohit Saxena Pradeep Sharma Vasundhra Misra Deepti Vibha Awadh Kishor Pandit Source Type: research
Catalysis of indium ion electroreduction in the presence of acetazolamide in chlorates(VII) solutions with varied water activity
Chemphyschem. 2024 Feb 16:e202300789. doi: 10.1002/cphc.202300789. Online ahead of print.ABSTRACTThe influence of acetazolamide (ACT) on the kinetics and the mechanism of electroreduction of In(III) ions as a function of changes of the water activity was investigated using electrochemical methods (DC, SWV, CV and EIS, CV). The multi-step mechanism of the electroreduction process should take into account the dehydration step of indium ions and the presence of In - ACT (,,cap-pair" effect) active complexes, mediating electron transfer, located in the adsorption layer. Differences in the electrode mechanism in the presence of...
Source: Chemphyschem - February 16, 2024 Category: Chemistry Authors: Agnieszka Nosal-Wierci ńska Marlena Martyna Anna Szabelska Beata Go łębiowska Source Type: research
Tailored Tetrasubstituted Imidazole Carrying the Benzenesulfonamide Fragments as Selective Human Carbonic Anhydrase IX/XII Inhibitors
ChemMedChem. 2024 Feb 15:e202400004. doi: 10.1002/cmdc.202400004. Online ahead of print.ABSTRACTA new series of tetrasubstituted imidazole carrying sulfonamide as zinc-anchoring group has been designed. The structures of the synthesized derivatives 5a-l have been confirmed by spectroscopic analysis. These compounds incorporate an ethylenic spacer between the benznesulfonamide and the rest of the trisubstituted imidazole moiety and were tested as inhibitors of carbonic anhydrases and for invitro cytotoxicity. Most of them act as effective inhibitors of the tumor-linked CA isoforms IX and XII, in nanomolar range. Also, diffe...
Source: ChemMedChem - February 15, 2024 Category: Chemistry Authors: Ehab S Taher Adel A Marzouk Walaa Hamada Abd-Allah Simone Giovannuzzi Tarek S Ibrahim Claudiu T Supuran Mohamed A El Hamd Mohammed Farrag Mohammed Ali El-Behairy Source Type: research
Tailored Tetrasubstituted Imidazole Carrying the Benzenesulfonamide Fragments as Selective Human Carbonic Anhydrase IX/XII Inhibitors
ChemMedChem. 2024 Feb 15:e202400004. doi: 10.1002/cmdc.202400004. Online ahead of print.ABSTRACTA new series of tetrasubstituted imidazole carrying sulfonamide as zinc-anchoring group has been designed. The structures of the synthesized derivatives 5a-l have been confirmed by spectroscopic analysis. These compounds incorporate an ethylenic spacer between the benznesulfonamide and the rest of the trisubstituted imidazole moiety and were tested as inhibitors of carbonic anhydrases and for invitro cytotoxicity. Most of them act as effective inhibitors of the tumor-linked CA isoforms IX and XII, in nanomolar range. Also, diffe...
Source: ChemMedChem - February 15, 2024 Category: Chemistry Authors: Ehab S Taher Adel A Marzouk Walaa Hamada Abd-Allah Simone Giovannuzzi Tarek S Ibrahim Claudiu T Supuran Mohamed A El Hamd Mohammed Farrag Mohammed Ali El-Behairy Source Type: research
Tailored Tetrasubstituted Imidazole Carrying the Benzenesulfonamide Fragments as Selective Human Carbonic Anhydrase IX/XII Inhibitors
ChemMedChem. 2024 Feb 15:e202400004. doi: 10.1002/cmdc.202400004. Online ahead of print.ABSTRACTA new series of tetrasubstituted imidazole carrying sulfonamide as zinc-anchoring group has been designed. The structures of the synthesized derivatives 5a-l have been confirmed by spectroscopic analysis. These compounds incorporate an ethylenic spacer between the benznesulfonamide and the rest of the trisubstituted imidazole moiety and were tested as inhibitors of carbonic anhydrases and for invitro cytotoxicity. Most of them act as effective inhibitors of the tumor-linked CA isoforms IX and XII, in nanomolar range. Also, diffe...
Source: ChemMedChem - February 15, 2024 Category: Chemistry Authors: Ehab S Taher Adel A Marzouk Walaa Hamada Abd-Allah Simone Giovannuzzi Tarek S Ibrahim Claudiu T Supuran Mohamed A El Hamd Mohammed Farrag Mohammed Ali El-Behairy Source Type: research
Tailored Tetrasubstituted Imidazole Carrying the Benzenesulfonamide Fragments as Selective Human Carbonic Anhydrase IX/XII Inhibitors
ChemMedChem. 2024 Feb 15:e202400004. doi: 10.1002/cmdc.202400004. Online ahead of print.ABSTRACTA new series of tetrasubstituted imidazole carrying sulfonamide as zinc-anchoring group has been designed. The structures of the synthesized derivatives 5a-l have been confirmed by spectroscopic analysis. These compounds incorporate an ethylenic spacer between the benznesulfonamide and the rest of the trisubstituted imidazole moiety and were tested as inhibitors of carbonic anhydrases and for invitro cytotoxicity. Most of them act as effective inhibitors of the tumor-linked CA isoforms IX and XII, in nanomolar range. Also, diffe...
Source: ChemMedChem - February 15, 2024 Category: Chemistry Authors: Ehab S Taher Adel A Marzouk Walaa Hamada Abd-Allah Simone Giovannuzzi Tarek S Ibrahim Claudiu T Supuran Mohamed A El Hamd Mohammed Farrag Mohammed Ali El-Behairy Source Type: research
Combination pharmacological therapy targeting multiple mechanisms of sleep apnoea: a randomised controlled cross-over trial
Conclusions
While AtoOxy halved AHI, and acetazolamide lowered AHI by a third, the combination of these leading experimental interventions provided no greater efficacy than AtoOxy alone. Failure of acetazolamide to further increase efficacy suggests overlapping physiological mechanisms.
Trial registration number
NCT03892772. (Source: Thorax)
Source: Thorax - February 15, 2024 Category: Respiratory Medicine Authors: Sands, S. A., Collet, J., Gell, L. K., Calianese, N., Hess, L. B., Vena, D., Azarbarzin, A., Bertisch, S. M., Landry, S., Thomson, L., Joosten, S. A., Hamilton, G. S., Edwards, B. A. Tags: Thorax Sleep Source Type: research
The dopamine D2 receptors antagonist Veralipride inhibits carbonic anhydrases: solution and crystallographic insights on human isoforms
Chem Asian J. 2024 Feb 9:e202400067. doi: 10.1002/asia.202400067. Online ahead of print.ABSTRACTThe inhibitory effects of veralipride, a benzamide-class antipsychotic acting as dopamine D2 receptors antagonist incorporates a primary sulfonamide moiety and was investigated for its interactions with carbonic anhydrase (CA) isoforms. In vitro profiling using the stopped-flow technique revealed that veralipride exhibited potent inhibitory activity across all tested hCA isoforms, with exception of hCA III. Comparative analysis with standard inhibitors, acetazolamide (AAZ), and sulpiride, provided insights for understanding the ...
Source: Chemistry, an Asian Journal - February 9, 2024 Category: Chemistry Authors: Andrea Angeli Marta Ferraroni Clemente Capasso Claudiu T Supuran Source Type: research
