Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain
ConclusionsEfficiency of solute clearance in brain changes with alterations in both state of neuronal activity and CSF formation. Our clearance pathway and mechanism agnostic kinetic model informs about net solute transport, solely based on the measured time signal curves. This rather simplifying approach largely accords with preclinical and clinical findings. (Source: Fluids and Barriers of the CNS)
Source: Fluids and Barriers of the CNS - June 14, 2023 Category: Neuroscience Source Type: research
Ventilatory function and oxygen delivery at high altitude in the Himalayas
This study aimed to evaluate changes in lung function assessed by spirometry and blood gas content in healthy high-altitude sojourners during a trek in the Himalayas. A group of 19 Italian adults (11 males and 8 females, mean age 43 ±15 years, and BMI 24.2 ±3.7kg/m2) were evaluated as part of a Mount Everest expedition in Nepal. Spirometry and arterial blood gas content were evaluated at baseline in Kathmandu (≈1400m), at the Pyramid Laboratory - Observatory (peak altitude of ≈5000m), and on return to Kathmandu 2-3 days after arrival at each site. All participants took 250mg of acetazolamide per os once daily during ...
Source: Respiratory Care - May 31, 2023 Category: Respiratory Medicine Authors: Pierpaolo Prosperi Vittore Verratti Alberto Taverna Riccardo Rua Sofia Bonan Giorgia Rapacchiale Danilo Bondi Camillo Di Giulio Jacek Lorkowski Antonella Spacone Source Type: research
Substituted furan sulfonamides as carbonic anhydrase inhibitors: Synthesis, biological and in silico studies
Bioorg Chem. 2023 May 24;138:106621. doi: 10.1016/j.bioorg.2023.106621. Online ahead of print.ABSTRACTCarbonic Anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide involved in several of biological processes, such as respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show wide diversity in tissue distribution and in their subcellular localization. Fifteen novel furyl sulfonamides were designed, synthesized and evaluated against four human isoforms: hCA I, hCA II...
Source: Bioorganic Chemistry - May 31, 2023 Category: Chemistry Authors: Andrea Angeli Victor Kartsev Anthi Petrou Boris Lichitsky Andrey Komogortsev Athina Geronikaki Claudiu T Supuran Source Type: research
Ventilatory function and oxygen delivery at high altitude in the Himalayas
This study aimed to evaluate changes in lung function assessed by spirometry and blood gas content in healthy high-altitude sojourners during a trek in the Himalayas. A group of 19 Italian adults (11 males and 8 females, mean age 43 ± 15 years, and BMI 24.2 ± 3.7 kg/m2) were evaluated as part of a Mount Everest expedition in Nepal. Spirometry and arterial blood gas content were evaluated at baseline in Kathmandu (≈1400 m), at the Pyramid Laboratory - Observatory (peak altitude of ≈5000 m), and on return to Kathmandu 2-3 days after arrival at each site. All participants took 250 mg of acetazolamide per os once daily d...
Source: Respiratory Care - May 31, 2023 Category: Respiratory Medicine Authors: Pierpaolo Prosperi Vittore Verratti Alberto Taverna Riccardo Rua Sofia Bonan Giorgia Rapacchiale Danilo Bondi Camillo Di Giulio Jacek Lorkowski Antonella Spacone Source Type: research
