Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain

ConclusionsEfficiency of solute clearance in brain changes with alterations in both state of neuronal activity and CSF formation. Our clearance pathway and mechanism agnostic kinetic model informs about net solute transport, solely based on the measured time signal curves. This rather simplifying approach largely accords with preclinical and clinical findings.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research