Intravenous acetazolamide for acute decompensated heart failure – ADVOR Study
Intravenous acetazolamide for acute decompensated heart failure – ADVOR Study
Acetazolamide in Decompensated Heart Failure With Volume OveRload (ADVOR) study assessed whether intravenous acetazolamide can improve the efficacy of loop diuretics in acute decompensated heart failure with volume overload. Acetazolamide is a carbonic anhydrase inhibitor that reduces proximal tubular sodium reabsorption. It was a multicenter, double blind randomized, placebo controlled trial. Edema, pleural effusion and ascites were the important features of volume overload [1].
Ascites was confirmed by abdominal ultrasound and pleural eff...
Source: Cardiophile MD - September 24, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
AI Startup AESOP Raises $3M to Tackle Medical and Billing Errors
Digital health startup AESOP Technology has raised a $2.95 million series pre-A round to address the growing medical and billing errors problem. The round was led by Taiwania Capital with participation from Colopl Next, 500 Startups, and BE Capital.
Originally from Taiwan, AESOP started as a university spin-off from Taipei Medical University (TMU). Professor Yu Chuan (Jack) Li, the founder and current president at the International Medical Informatics Association, spent ten years before AESOP working on big data approaches to reduce medication errors. He initially applied the model to launch a product, RxPrime (previo...
Source: EMR and HIPAA - September 13, 2022 Category: Information Technology Authors: Healthcare IT News Tags: AI/Machine Learning Health IT Company Healthcare IT 500 Startups AESOP AESOP Technology BE Capital Colopl Next Dr. Jeremiah Scholl Dr. Jim Long DxPrime Health IT Funding Health IT Fundings Health IT Investment International Med Source Type: blogs
Fluids and electrolytes: Potassium-sparing diuretics
Sabrine Elkhodr Fluids and electrolytes: Potassium-sparing diuretics
In this video Joel Topf looks at acetazolamide and potassium-sparing diuretics; how to optimise your patients’ diuretic regimen; the advantages and disadvantages of each diuretic; and what to do when they don’t work. (Source: Life in the Fast Lane)
Source: Life in the Fast Lane - April 25, 2019 Category: Emergency Medicine Authors: Sabrine Elkhodr Tags: Medmastery Podcast acetazolamide diuretic Fluids and Electrolytes Joel Topf Potassium-sparing Potassium-sparing diuretics Source Type: blogs
I Can’t Hear You!
A 50-year-old man presented to the emergency department complaining of ringing in his ears and difficulty understanding what people were saying. He was concerned that he was having a stroke. A full neurological exam was unremarkable aside from decreased hearing, but his hearing deficits appeared to be equal bilaterally. Otoscopic exam demonstrated a normal tympanic membrane, and the rest of his physical exam was unremarkable. The patient's past medical history was significant for hypertension and hypercholesterolemia, for which he took lisinopril and atorvastatin. He was recently treated with a 10-day course of doxycycl...
Source: The Tox Cave - April 1, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Acute Angle Closure: Mastering Tonometry
Identifying and managing disease often requires the delicate and skillful use of temperamental emergency department machinery. The ability to apply these may appropriately help determine a difficult diagnosis.Glaucoma, we all know, can cause blindness, and acute narrow angle glaucoma refers to the angles within the eye that are not as wide and open as normal. People with acute angle glaucoma have abnormal anatomy within the eye where the angle changes as the eye is dilated. This can cause blockages of fluid drainage from the anterior to posterior changes resulting in increased intraocular pressure. It ca lead to acute a...
Source: The Procedural Pause - November 9, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
An Approach to Interfering in Mitochondrially Mediated Cell Death due to Amyloid- β in Alzheimer's Disease
In this study, we examine multiple mitochondrial pathways of amyloid toxicity in neuronal and cerebral endothelial cells (ECs), and evaluate CAIs methazolamide (MTZ) and, for the first time, its analog acetazolamide (ATZ), on specific Aβ-mediated pathways of mitochondrial dysfunction and apoptotic cell death. The CAIs selectively inhibited mitochondrial dysfunction pathways induced by Aβ, without affecting metabolic function.
Due to the long-term use of MTZ and ATZ in chronic conditions, the efficacy and the safety of their systemic administration have been widely assessed, making clinical trials for CAIs in AD a ...
Source: Fight Aging! - June 22, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A middle aged man with unwitnessed cardiac arrest
Written by Pendell Meyers, with edits by Steve SmithThanks to my attending Nic Thompson who superbly led this resuscitationWe received a call that a middle aged male in cardiac arrest was 5 minutes out. He was estimated to be in his 50s, with no known PMHx. He arrived with chest compressions ongoing, intubated, and being bagged. EMS report was that the patient had unknown down time with unwitnessed arrest, found initially in VFib arrest, defibrillated x1 followed by PEA arrest alternating with asystolic arrest during transport.He arrived in PEA arrest with a slow and wide cardiac waveform during initial rhythm check, with ...
Source: Dr. Smith's ECG Blog - April 6, 2018 Category: Cardiology Authors: Pendell Source Type: blogs
LITFL Review 220
Welcome to the 220th LITFL Review! Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chuck of FOAM.
The Most Fair Dinkum Ripper Beauts of the Week
The world is buzzing about Zika Virus. Found out what you need to know this week from emDocs. [MG]
Interesting perspective on the Zika virus in this week’s NEJM, describing the “pandemic expansion of multiple, heretofore relatively unimport...
Source: Life in the Fast Lane - February 21, 2016 Category: Emergency Medicine Authors: Marjorie Lazoff, MD Tags: Education LITFL review Source Type: blogs
A recognition primed decision model approach to the BMP problem
To restate the problem:
The basic metabolic panel is very valuable. Too many students, residents and physicians seem to have an incomplete understanding of the information that the BMP can provide. This recent patient may make my point.
80-year-old patient admitted for hematemesis. Patient required several transfusions and volume resuscitation. No history of significant heart disease or lung disease. The patient spent 4 days in the ICU and then is transferred to our team early Monday morning. The intern briefly sees the patient and says she is stable – but does mention that she requires 3 liters nasal oxygen (no prio...
Source: DB's Medical Rants - August 11, 2015 Category: Internal Medicine Authors: rcentor Tags: Acid-Base & Lytes Source Type: blogs
Research and Reviews in the Fastlane 047
In this study, the research team collected pooled urine (read many people used the urinal they collected from) from a popular nightclub area in London and analyzed the specimens for the presence of illicit drug compounds. The goal was to determine whether this method could be used to track patterns and monitor trends in recreational drug use.
Recommended by: Anand Swaminathan
Emergency Medicine, Critical Care, Anaesthetics
Hindman BJ et al. Intubation Biomechanics: Laryngoscope Force and Cervical Spine Motion during Intubation with Macintosh and Airtraq Laryngoscopes. Anesthesiology. 2014; 121(2):260-71. PMID...
Source: Life in the Fast Lane - September 9, 2014 Category: Emergency Medicine Authors: Anand Swaminathan Tags: Clinical Research Education Emergency Medicine R&R in the FASTLANE critical care Intensive Care literature recommendations Research and Review Source Type: blogs
A Fisherman’s Friend… or Foe?
aka Toxicology Conundrum 052
A 64 year-old male was brought in after a collapse at home. He had been sitting on the couch with his wife when she noticed that he had gone limp and was not breathing. Bystander CPR was performed for 15 minutes until ambulance crews arrived. He received 2x DC 200J shock for ventricular fibrillation, after which he had a return of spontaneous circulation, with HR 80 sinus rhythm, BP 90/60 and GCS 3. In the Emergency department he received 300mg Amiodarone, and cooling was commenced as per out of hospital cardiac arrest protocol at that time. He had a further episode of VF arrest soon after ar...
Source: Life in the Fast Lane - March 5, 2014 Category: Emergency Medicine Doctors Authors: Kylie McNamara Tags: Clinical Case Emergency Medicine Featured Intensive Care Toxicology Toxicology Quiz cardiac arrest ECG Glycyrrhizic acidm hypokalemia laboratory results licorice liquorice Source Type: blogs
Do Alzheimer's Medications Work, Who Should Take Them?
Over the years my clients have asked me, “Should my loved one be taking any of the Alzheimer’s medications?”
By Bob DeMarco
Alzheimer's Reading Room
Over the years my answer has differed depending on how much I knew about the medications, the relative costs of the medications, and how much research has been done on the effectiveness of the medications. Here is what I’m saying currently.
There are only 5 medicines that the FDA has approved for treatment of Alzheimer’s disease.
None of the medications cure the disease. None of the medications stop the disease process from continuing on long term,...
Source: Alzheimer's Reading Room, The - April 15, 2013 Category: Dementia Authors: Bob DeMarco Source Type: blogs