Combination pharmacological therapy targeting multiple mechanisms of sleep apnoea: a randomised controlled cross-over trial

Conclusions
While AtoOxy halved AHI, and acetazolamide lowered AHI by a third, the combination of these leading experimental interventions provided no greater efficacy than AtoOxy alone. Failure of acetazolamide to further increase efficacy suggests overlapping physiological mechanisms.

Trial registration number
NCT03892772.

Source: Thorax - February 15, 2024 Category: Respiratory Medicine Authors: Sands, S. A., Collet, J., Gell, L. K., Calianese, N., Hess, L. B., Vena, D., Azarbarzin, A., Bertisch, S. M., Landry, S., Thomson, L., Joosten, S. A., Hamilton, G. S., Edwards, B. A. Tags: Thorax Sleep Source Type: research