Antioxidant and anti-inflammatory effects of intravenously injected adipose derived mesenchymal stem cells in dogs with acute spinal cord injury
Conclusion:
Our results suggest that early intravenous injection of AD-MSCs after acute SCI may prevent further damage through enhancement of antioxidative and anti-inflammatory mechanisms, without inducing adverse effects. Additionally, this treatment could also be used as an alternative intravenous treatment modality for acute SCI. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 26, 2015 Category: Stem Cells Authors: Yongsun KimSung-ho JoWan KimOh-Kyeong Kweon Source Type: research
Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models
Conclusion Severe generalized allodynia was observed after high intrathecal doses of MP and MPA in naive rats. No acute analgesic effects with intrathecal glucocorticoids were observed in three well established pain models. Only a late antiallodynic effect was present in the formalin model, 7 days after formalin injection and drug treatment. Implications Our results do not support use of intrathecal methylprednisolone in the treatment of pain. (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - November 21, 2015 Category: Anesthesiology Source Type: research
Hypoxia enhances glucocorticoid-induced apoptosis and cell cycle arrest via the PI3K/Akt signaling pathway in osteoblastic cells
In conclusion, our results demonstrate that MPSL, a synthetic glucocorticoid receptor agonist, promotes the level of p85α and inhibits PI3K/Akt signaling to induce apoptosis and cell cycle arrest in osteoblasts, and that this effect is enhanced under hypoxic conditions. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 25, 2015 Category: Orthopaedics Source Type: research
The effects of Diet and corticosteroid-induced immune suppression during infection by Haemonchus contortus in lambs
In conclusion, the changes caused in the rumen contents by supplementation with concentrate did not impair H. contortus establishment. (Source: Veterinary Parasitology)
Source: Veterinary Parasitology - September 11, 2015 Category: Veterinary Research Source Type: research
A Placebo‐Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation
ConclusionsThis clinical trial did not show a benefit of either MPSS or PEG in the treatment of acute, severe thoracolumbar IVDH when used as adjunctive medical treatment administered to dogs presenting within 24 hours of onset of paralysis. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - September 1, 2015 Category: Veterinary Research Authors: N.J. Olby, A.C. Muguet‐Chanoit, J.‐H. Lim, M. Davidian, C.L. Mariani, A.C. Freeman, S.R. Platt, J. Humphrey, M. Kent, C. Giovanella, R. Longshore, P.J. Early, K.R. Muñana Tags: Standard Article Source Type: research
Use of Mometasone furoate in prolonged treatment of experimental spinal cord injury in mice: A comparative study of three different glucocorticoids
Publication date: Available online 17 July 2015 Source:Pharmacological Research Author(s): Maria Galuppo, Antonietta Rossi, Sabrina Giacoppo, Simona Pace, Placido Bramanti, Lidia Sautebin, Emanuela Mazzon Traumatic spinal cord injury (SCI) represents one of the most disabling injuries of the human body causing temporary or permanent sensory and/or motor system deficit, particularly hind limb locomotor function impairment. At present, steroidal inflammatory drugs, in particular methylprednisolone sodium succinate (MPSS) are the first line choice treatment of acute SCI. Despite progress in pharmacological, ...
Source: Pharmacological Research - July 17, 2015 Category: Drugs & Pharmacology Source Type: research
Effects of Therapeutic Hypothermia on Apoptosis and Autophagy After Spinal Cord Injury in Rats
Conclusion. Both TH and MP have neuroprotective effects on injured spinal cord tissues via the inhibition of apoptosis and autophagy. Thus, the application of moderate systemic hypothermia may be a useful treatment modality after acute SCI.
Level of Evidence: N/A (Source: Spine)
Source: Spine - June 12, 2015 Category: Orthopaedics Tags: Basic Science Source Type: research
Local application of corticosteroids combined with surgery for the treatment of chronic subdural hematoma.
CONCLUSION: The results suggest that local application of MPSS combined with surgery is a safe and effective method in the management of CSH. It may reduce hematoma recurrence.
PMID: 26014008 [PubMed - in process] (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - May 31, 2015 Category: Neurosurgery Authors: Xu XP, Liu C, Liu J, Pang YG, O XD, Fu J, Zhou L, Fan YZ Tags: Turk Neurosurg Source Type: research
Neuroprotective therapy with granulocyte colony-stimulating factor in acute spinal cord injury: a comparison with high-dose methylprednisolone as a historical control
Conclusions
These results suggest that G-CSF administration is safe and effective, but a prospective randomized controlled clinical trial is needed to compare the efficacy of MPSS versus G-CSF treatment in patients with SCI. (Source: European Spine Journal)
Source: European Spine Journal - April 29, 2015 Category: Orthopaedics Source Type: research
Hypoxia enhances glucocorticoid-induced apoptosis and cell cycle arrest via the PI3K/Akt signaling pathway in osteoblastic cells
In conclusion, our results demonstrate that MPSL, a synthetic glucocorticoid receptor agonist, promotes the level of p85α and inhibits PI3K/Akt signaling to induce apoptosis and cell cycle arrest in osteoblasts, and that this effect is enhanced under hypoxic conditions. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 18, 2014 Category: Orthopaedics Source Type: research
Effects of methylprednisolone, dantrolene, and their combination on experimental spinal cord injury.
This study aimed to evaluate the effect of methylprednisolone sodium succinate, dantrolene sodium, and their combination on experimental spinal cord injury. We used 25 rats (Rattus norvegicus) that were divided into five groups. The negative control group (NC) consisted of animals without spinal cord trauma. In the groups with spinal cord trauma, the positive control group (PC) was given no treatment, the MS group was treated with methylprednisolone, the MS/DS group was treated with methylprednisolone and dantrolene, and the DS group was treated with dantrolene alone. The animals' motor function was evaluated daily, as mea...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Rosado IR, Lavor MS, Alves EG, Fukushima FB, Oliveira KM, Silva CM, Caldeira FM, Costa PM, Melo EG Tags: Int J Clin Exp Pathol Source Type: research
Application of immunosuppressant facilitates the therapy of optic neuritis combined with Sjögren's syndrome.
CONCLUSIONS: The effect of immunosuppressant plus corticosteroid on the early onset of ON combined with SS was to provide ON remedy and to prevent recurrence in clinics. This study provides a significant reference for the prevention and treatment of ON on the basis of immunosuppressant and corticosteroid.
PMID: 25189952 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - September 1, 2014 Category: Journals (General) Authors: Li H, Liu Z, Gong Y, Jiang Z, Zhang Y, Dai Y, Zhang Y, Wei S Tags: Chin Med J (Engl) Source Type: research
The dose-dependent neuroprotective effect of alpha-lipoic acid in experimental spinal cord injury.
Conclusions: Alpha lipoic acid at a dose range of 50-150 mg/ kg is as effective as MPSS (30 mg/kg) in neuroprotection after SCI. Further, more detailed experimental studies are needed to determine the effects of ALA on the detrimental results of secondary SCI before its use in humans.
PMID: 23986424 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - September 3, 2013 Category: Neurology Authors: Sayın M, Temiz P, Var A, Temiz C Tags: Neurol Neurochir Pol Source Type: research
Quercetin prevents experimental glucocorticoid-induced osteoporosis: a comparative study with alendronate.
Abstract
Glucocorticoid-induced osteoporosis (GIO) is the most common type of secondary osteoporosis. The aim of this study was to compare the efficacy of quercetin, a plant-derived flavonoid, with alendronate in the prevention of GIO. Fifty-six Sprague-Dawley rats were randomly distributed among 7 groups (8 rats per group) and treated for 6 weeks with one of the following: (i) normal saline; (ii) 40 mg methylprednisolone sodium succinate (MP)/kg body mass; (iii) MP + 40 μg alendronate/kg; (iv) MP + 50 mg quercetin/kg; (v) MP + 40 μg alendronate/kg + 50 mg quercetin/kg; (vi) MP + 150 mg quercetin/kg; and...
Source: Canadian Journal of Physiology and Pharmacology - May 1, 2013 Category: Drugs & Pharmacology Authors: Derakhshanian H, Djalali M, Djazayery A, Nourijelyani K, Ghadbeigi S, Pishva H, Saedisomeolia A, Bahremand A, Dehpour AR Tags: Can J Physiol Pharmacol Source Type: research
Cryptogenic Organizing Pneumonia During Adjuvant Chemotherapy With Oxaliplatin, 5-Fluorouracil, and Leucovorin (FOLFOX) for Colon Cancer
We describe a case of cryptogenic organizing pneumonia (COP) occurring in a 78-year-old woman after receiving 2 cycles of modified FOLFOX6 as adjuvant chemotherapy for treatment of resected nonmetastatic colon cancer. This patient presented with respiratory symptoms including cough with scant clear sputum and wheezing on day 10 of the second cycle of mFOLFOX6. Despite therapy with systemic antibiotics and supplemental oxygen, she had a steady and relentless progression of her respiratory symptoms and status, with chest radiographs revealing progressive bilateral pulmonary infiltrates. Further chest radiograph evaluation de...
Source: Journal of Pharmacy Practice - February 15, 2013 Category: Drugs & Pharmacology Authors: Shogbon, A. O., Hap, J., Dretler, R., Dalvi, A. G. Tags: Adverse Drug Events Source Type: research
