Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models

Conclusion Severe generalized allodynia was observed after high intrathecal doses of MP and MPA in naive rats. No acute analgesic effects with intrathecal glucocorticoids were observed in three well established pain models. Only a late antiallodynic effect was present in the formalin model, 7 days after formalin injection and drug treatment. Implications Our results do not support use of intrathecal methylprednisolone in the treatment of pain.
Source: Scandinavian Journal of Pain - Category: Anesthesiology Source Type: research