Management of oral leukoplakia in patients with Fanconi anemia
Roberto Pippi, Cira Di Gioia, Ursula La Rocca, Amelia Bellisario, Anna Paola IoriJournal of Oral and Maxillofacial Pathology 2022 26(5):133-138
Fanconi anemia (FA) is a rare genetic disease involving an increased risk of developing acute myeloid leukemia and solid tumors, especially head-and-neck squamous cell carcinomas, for which the oral cavity is the most frequent site of occurrence. The patient presented in this study underwent allogeneic hematopoietic stem cell transplantation (HSCT) and developed nonhomogeneous oral leukoplakia after 7 years, which was promptly removed and diagnosed with high-grade epithelial dysplasia. Many risk conditions for oral squamous cell carcinoma were featured in the present case including FA, allogeneic HSCT, graft-versus-host disease, immunosuppressive therapy, female gender, nonsmoker, tongue location and nonhomogeneous type of leukoplakia. Close follow-up of the entire upper aerodigestive tract mucosa and early removal of all suspected lesions are highly recommended in the management of such patients.
Source: Journal of Oral and Maxillofacial Pathology - Category: ENT & OMF Authors: Roberto Pippi Cira Di Gioia Ursula La Rocca Amelia Bellisario Anna Paola Iori Source Type: research
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