New Opdivo/Yervoy Mesothelioma Clinical Trial Begins Soon

A novel clinical trial involving the immunotherapy combination of Opdivo and Yervoy will open soon in Chicago. The goal is to study the drugs’ efficacy when added to surgery for patients with peritoneal mesothelioma cancer. The single-center, phase II clinical trial follows a recent report detailing the impressive three-year effectiveness of the drug combination when used for unresectable pleural mesothelioma. Bristol Myers Squibb manufactures Opdivo and Yervoy, known generically as nivolumab and ipilimumab. The U.S. Food and Drug Administration approved the combination for pleural mesothelioma in 2020, making it the first new systemic mesothelioma treatment in 15 years. Health organizations around the world, including those in Japan, China and the European Union, have issued similar first-line treatment approval. This latest clinical trial is expected to include close to 40 patients and last at least three years. It was approved in September and is scheduled to begin Jan. 1, at the University of Chicago Medicine Comprehensive Cancer Center. Participation, including pre-surgery treatment, post-surgery treatment and observation, will last at least 18 months. Researchers Expand Use of Immunotherapy An estimated 1,000 people are diagnosed annually in the U.S. with peritoneal mesothelioma, which develops in the thin layer of tissue lining the abdomen and often spreads throughout the abdominal cavity. Pleural mesothelioma grows in the tissue lining the lungs a...
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The expanded approval is for the adjuvant treatment of advanced melanoma after complete resection in patients aged 12 years and older.Medscape Medical News
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Dalton Trans., 2021, Accepted Manuscript DOI: 10.1039/D1DT03364F, PaperDejan Simic, Milan Zaric, Ivana Nikolic, Radica Zivkovic Zaric, Petar Canovic, Aleksandar Kocovic, Ivana Radojevic, Ivana Rakovic, Sandra Jovicic Milic, Djordje Petrovic, Danijela Stojkovic, Nenad Vukovic, Miroslava Ka čániová, Milena Vukic, Verica Jevtic A five new complexes of palladium(II) ion (C1 –C5) general formula [PdL2)]Cl2 with some 2-aminothiazoles (L1-L5) whereL1 = 2-amino-4-(3,4 difluorophenyl) thiazole,L2 = 2-amino-5-methyl-4-phenylthiazole,L3 = 2-amino-4-phenylthiazole,L4 = 2-amino-4-(4-chlorophenyl)... The content of ...
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Chris EdwardsThe main weapons against COVID-19 are the vaccines developed by Moderna and BioNTech after a decade of their research into mRNA technologies. That research was supported by more than $3 billion of private angel investment and venture capital.Democrats and Republicans both support medical research funding, and Republicans tout the Trump administration ’s Operation Warp Speed. But governments were not the key to mRNA development. Instead, we can thank the leaders and scientists at Moderna and BioNTech and the suppliers of private capital to them, as I discusshere andhere.TheWall Street Journal &r...
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Conclusion: Although there is no uniform definition of integrated care in China or abroad and each country has its own national definition and system of integrated care, there are certain commonalities regarding the needs of older adults and the factors that influence them across countries. Our research reveals a gap between China and the international community in terms of integrated care. Published on 2021-12-06 12:56:14
Source: International Journal of Integrated Care - Category: Nursing Source Type: research
No abstract available
Source: Cancer Nursing - Category: Nursing Tags: DEPARTMENTS: Guest Editorial Source Type: research
Background Fatigue and sleep disturbance are common co-occurring symptoms in patients receiving chemotherapy. While the results from meta-analyses support the use of exercise to decrease the severity of these symptoms, information is needed on patients’ “real world experiences” with the use of exercise. Objective The aims of this study were to determine distribution of patients who did and did not exercise on a regular basis and evaluate for differences in demographic and clinical characteristics, as well as the severity of fatigue, decrements in energy, and sleep disturbance among the exercise...
Source: Cancer Nursing - Category: Nursing Tags: ARTICLES Source Type: research
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