Cancer Screening Using 18F-FDG PET/MRI in Asymptomatic Subjects: A Multicenter Retrospective Study

Conclusions: Based on the findings in this study, we suggest that FDG PET/MRI might be an effective cancer screening modality, especially in combination with lung CT. Table 1.The cancer type distribution of the subjectsNumber of casesorganShanghaiHangzhouTotalLung461561Thyroid527Breast415Digestive system (Stomach, Colon)4(1,3)1(1,0)5Urogenital system (Kidney, Prostate, Cervical)7(2,4,1)1(0,1,0)8Nasopharynx213Tonsil101Total692190Table 2. False positive cases detected by PET/MROrganShanghaiHangzhouTotalThyroid10616Colon112Stomach101Breast202Total14721Table 3.False negative cases missed by PET/MRNO.CenterAgeSexOrganHistological diagnosisMethods of confirmation1Shanghai56MStomachGastric cancerGastroscope + histology2Shanghai46FBreastBreast cancerSurgery + histology3Shanghai55FUterusEndometrial carcinomaSurgery + histology4Shanghai48MColonColon cancerColonoscopy + histology5Shanghai49FThyroidThyroid carcinomaSurgery + histology6Hangzhou70MStomachGastric cancerGastroscope + histologyTable 4. Statistical results of multicenter by PET/MRIShanghaiHangzhouShanghai+HangzhouDetection rate(PET/MRI with lung CT)2.75%2.59%2.71%Detection rateïcirc;PET/MRIï1/41.56%1.57%1.57%Sensitivity93.24%95.45%93.75%Specificity99.52%99.33%99.47%Positive predictive value83.13%75.0%81.08%Negative predictive value99.82%99.90%99.85%

Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Peng, L., Sun, M., Feng, G., Lin, M., Gao, X. Tags: Miscellaneous Source Type: research