Flu research may lead to universal vaccine

Conclusion This research has identified that CD8+ T-cells are linked with protection against different strains of influenza. They are also linked with reduced severity of flu. The authors note that current vaccines that use inactivated forms of the flu virus protect against specific strains, and do not induce a strong maintained T-cell response. They suggest that, in light of their findings, this may be the reason why they produce limited protection across different subtypes of influenza virus. They say that further testing is needed to see if the live vaccines being used are better at producing cross-subtype protection, and if they do this via CD8+ T-cells. The study does have some limitations, such as its relatively small size, and the fact that results may not apply to less healthy or older adults, who are most at risk from flu infection. However, these findings provide an important starting point for further investigation of these populations. Developing a universal flu vaccine has been a long-term goal of the flu vaccine industry, but it has been difficult to achieve because not enough has been understood about cross-strain immunity. The current findings suggest that vaccines that are capable of inducing a lasting CD8+ T-cell response could offer wider protection. Overall, this study provides useful insight into how a universal flu vaccine might work, and how to measure whether it might work. Analysis by Bazian. Edited by NHS Choices. Follow Behind the Headlines on Tw...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medication Medical practice Source Type: news

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Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Conclusions: If the patients in this sample had been previously vaccinated with PCV13 plus PPV23, theoretically, 50.8% of the cases of invasive pneumococcal disease that required hospital admission could potentially have been prevented. Invasive pneumococcal disease should be prevented by vaccination not only of children and the elderly but also of adults in their economically productive years, so as to reduce the socioeconomic costs, morbidity, and mortality s till associated with the disease, especially in underdeveloped countries.RESUMO Objetivo: Avaliar os sorotipos de Streptococcus pneumoniae isolados de uma popula &c...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
ABSTRACT Community-acquired pneumonia (CAP) is the leading cause of death worldwide. Despite the vast diversity of respiratory microbiota, Streptococcus pneumoniae remains the most prevalent pathogen among etiologic agents. Despite the significant decrease in the mortality rates for lower respiratory tract infections in recent decades, CAP ranks third as a cause of death in Brazil. Since the latest Guidelines on CAP from the Sociedade Brasileira de Pneumologia e Tisiologia (SBPT, Brazilian Thoracic Association) were published (2009), there have been major advances in the application of imaging tests, in etiologic investiga...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
Authors: Fisser C, Hamer OW, Eiber R, Pfeifer M, Lerzer C Abstract Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease. PAP results from impaired surfactant clearance. In adults, autoimmune pulmonary alveolar proteinosis is present in 90 - 95 % of the cases. In 5 - 10 %, other etiologies such as toxins and dust exposure, hematological disorders and infections have to be considered. Men between 30 - 60 years are commonly affected. Typical symptoms are cough, dyspnea and alteration in ventilatory function. CT scan of the lung is characterised by a crazy paving pattern. In serological test...
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
Conclusions: Wheezing prevalence in the first year of life remains high. Despite the temporal assessment showing a decrease in the prevalence of recurrent wheezing, a significant increase in its morbidity was identified due to the higher number of hospitalizations. In addition, there were signs of improvement in the wheezing management of infants, reflected by an increase in the diagnosis of asthma and a greater indication of preventive treatments.
Source: Revista Paulista de Pediatria - Category: Pediatrics Source Type: research
ABSTRACT The aim of this work was to evaluate patients with chronic migraine treated with botulinum toxin A (BT-A) and compare this with low level laser therapy (LLLT), referencing: pain days, pain intensity, intake of drugs/self-medication, anxiety and sleep disorders. Methods: Patients were randomized into two groups: BT-A group (n = 18) and LLLT group (n = 18). Each patient kept three pain diaries: one before (baseline) (30 days), one during treatment (30 days) and one after the post-treatment phase (30 days). Repeated ANOVA plus the Bonferroni post-test, Student's t test, and factorial analysis were applied, and p
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
Conclusions: The use of more drugs was not better at improving headache. However, there is the possibility that acting simultaneously on different sites may promote broader modulation and better outcome.RESUMO Objetivos: Cefaleia por uso excessivo de medicamentos (CEM) é comum em centros terciários. Existe evidência limitada quanto a estratégias de tratamento e se combinar drogas é melhor do que abordagens com monoterapia. Objetivamos comparar o uso de até dois, três ou quatro agentes farmacológicos para a prevenção. Métodos: Estudo retrospectivo de...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
Malignancy must be considered in the management of adrenal lesions, including those incidentally identified on imaging studies. Adrenocortical carcinomas (ACCs) are rare tumors with an estimated annual incidence of 0.7-2 cases per year and a worldwide prevalence of 4-12 cases per million/year. However, a much higher incidence of these tumors (>15 times) has been demonstrated in south and southeastern Brazil. Most ACCs cause hypersecretion of steroids including glucocorticoids and androgens. ACC patients have a very poor prognosis with a 5-year overall survival (OS) below 30% in most series. Pheochromocytoma or paragangl...
Source: Clinics - Category: General Medicine Source Type: research
Publication date: Available online 11 December 2018Source: Microbial PathogenesisAuthor(s): Ashraf Mohabati Mobarez, Roya Ahamad Rajabi, Ali Hatef Salmanian, Nima Khoramabadi, Seyed Reza Hosseini DoustAbstractLegionella pneumophila causes a severe form of pneumonia known as Legionnaires’ disease especially in patients with impaired cellular immune response. In order to prevent the disease, immunogenicity and the level of the induction of protective immunity from the recombinant peptidoglycan–associated lipoprotein (rPAL) against Legionella pneumophila in BALB/c mice was examined. Mice immunized with (rPAL) rapi...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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