Cancers, Vol. 12, Pages 210: Metformin as Potential Therapy for High-Grade Glioma
Cancers, Vol. 12, Pages 210: Metformin as Potential Therapy for High-Grade Glioma
Cancers doi: 10.3390/cancers12010210
Authors:
Marek Mazurek
Jakub Litak
Piotr Kamieniak
Bartłomiej Kulesza
Katarzyna Jonak
Jacek Baj
Cezary Grochowski
Metformin (MET), 1,1-dimethylbiguanide hydrochloride, is a biguanide drug used as the first-line medication in the treatment of type 2 diabetes. The recent years have brought many observations showing metformin in its new role. The drug, commonly used in the therapy of diabetes, may also find application in the therapy of a vast variety of tumors. Its effectiveness has been demonstrated in colon, breast, prostate, pancreatic cancer, leukemia, melanoma, lung and endometrial carcinoma, as well as in gliomas. This is especially important in light of the poor options offered to patients in the case of high-grade gliomas, which include glioblastoma (GBM). A thorough understanding of the mechanism of action of metformin can make it possible to discover new drugs that could be used in neoplasm therapy.
Source: Cancers - Category: Cancer & Oncology Authors: Marek Mazurek Jakub Litak Piotr Kamieniak Bart łomiej Kulesza Katarzyna Jonak Jacek Baj Cezary Grochowski Tags: Article Source Type: research
More News: Brain Tumor | Breast Carcinoma | Cancer | Cancer & Oncology | Carcinoma | Colon Cancer | Colorectal Cancer | Diabetes | Diabetes Type 2 | Endocrinology | Endometrial Cancer | Fortamet | Glioma | Leukemia | Melanoma | Metformin | Pancreas | Pancreatic Cancer | Skin Cancer