Development and validation of a simple risk model to predict major cancers for patients with nonalcoholic fatty liver disease

Seven risk factors including age (every 5  years), low‐density lipoprotein‐cholesterol, smoking, body mass index, diabetes, obstructive sleep apnea syndrome, and aspartate aminotransferase (every 5 units) were independent indicators of 8‐year cancer events in patients with NAFLD. A simple risk model and a score system were developed to predict the risk of cancer events after NAFLD based on 8‐year follow‐up of 1254 NAFLD patients. The risk model was well validated in the test samples (n = 627) and evaluation samples (n = 627) with 8‐year follow‐up. Importantly, the risk model performed well in another independent val idation samples (n = 3053). This risk model provides a basis for clinicians to better understand patients' risk of long‐term cancer events after NAFLD. AbstractObjectiveTo recognize risk factors and build up and validate a simple risk model predicting 8 ‐year cancer events after nonalcoholic fatty liver disease (NAFLD).MethodsThis was a retrospective cohort study. Patients with NAFLD (n  = 5561) were randomly divided into groups: training (n = 1254), test (n = 627), evaluation (n = 627), and validation (n = 3053). Risk factors were recognized by statistical method named as a Cox model with Markov chain Monte Carlo (MCMC) simulation. This prediction score was established b ased on the training group and was further validated based on the testing and evaluation gro...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research

Related Links:

SummaryBackgroundPharmacological treatment options for adolescents with obesity are very limited. Glucagon ‐like‐peptide‐1 (GLP‐1) receptor agonist could be a treatment option for adolescent obesity.ObjectiveTo investigate the effect of exenatide extended release on body mass index (BMI) ‐SDS as primary outcome, and glucose metabolism, cardiometabolic risk factors, liver steatosis, and other BMI metrics as secondary outcomes, and its safety and tolerability in adolescents with obesity.MethodsSix ‐month, randomized, double‐blinded, parallel, placebo‐controlled clinical trial in patients (n = 44, 10‐18&thin...
Source: Pediatric Obesity - Category: Eating Disorders & Weight Management Authors: Tags: ORIGINAL RESEARCH Source Type: research
(RMIT University) About 300,000 new cases of ovarian cancer are diagnosed globally each year, with about 60% of women dying within five years after diagnosis. A clinical trial has shown testing for a specific immune biomarker could improve diagnosis.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(American Cancer Society) A new study finds a wide state-by-state variation in rates of melanoma caused by ultraviolet (UV) exposure with highest rates in several states on the East and West Coast including Hawaii, but also a few landlocked states, including Utah, Vermont, and Minnesota.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
This is the first study to comprehensively measure both anatomical and non ‐anatomical OSA traits during sleep in those with COPD + OSA (Overlap syndrome) and compare them to those with OSA alone. No consistent differences were found between the two groups, while worsened lung function did impact upper airway function and control of breathing. These findings have impli cations towards mechanisms underlying OSA, as well as management of sleep apnea. AbstractOverlap syndrome (OVS) is the concurrence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), and is associated with poor outc...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: Available online 16 February 2020Source: The American Journal of SurgeryAuthor(s): Agnes Ewongwo, Mohammad Hamidi, Zana Alattar, Oluwatosin P. Ayotunde, Hina A. Tiwari, Emad Elquza, Aaron Scott, Kamil Hanna, Valentine NfonsamAbstractIntroductionThe aim of this study was to evaluate patient factors that contribute to increased incidence of early onset rectal cancer and analyze the short-term surgical outcomes of patients undergoing surgery.MethodsA 2-year review (2015–2016) of the ACS-NSQIP included patients with rectal cancer who underwent surgical management. Patients were stratified into early-onset RC (
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 16 February 2020Source: The American Journal of SurgeryAuthor(s): Chol-Ho Shin, Jong-Lyel Roh, Dong Eun Song, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon KimAbstractBackgroundTumour size and extrathyroidal extension (ETE) may impact papillary thyroid carcinoma (PTC) outcomes. We therefore examined the prognostic value of tumour size and ETE for predicting posttreatment recurrence in PTC patients.MethodsA total of 2,902 patients who underwent thyroidectomy for previously untreated T1–T3 PTC (7th edition American Joint Committee on Cancer) at our tertiary referral center wer...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionsIn SLNB positive MCC, CLND alone is associated with worse survival compared with treatment with adjuvant radiation or both CLND and adjuvant radiation.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionSurgery for BCLM is safe and might provide a survival benefit in selected patients but prospective trials are warranted to avoid selection bias.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: Available online 8 February 2020Source: European Journal of Surgical OncologyAuthor(s): Tibor Kovacs, Isabel Rubio, Christos Markopoulos, Riccardo A. Audisio, Susan Knox, Thorsten Kühn, Robert Mansel, Zoltan Matrai, Francesco Meani, Maurizio Nava, Lynda Wyld, BRESOExecutive summaryThe Breast Surgery theoretical and practical knowledge curriculum comprehensively describes the knowledge and skills expected of a fully trained surgeon practicing in the European Union and European Economic Area (EEA). It forms part of a range of factors that contribute to the delivery of high quality cancer care. It has b...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
More News: Cancer | Cancer & Oncology | Cholesterol | Colon Cancer | Colorectal Cancer | Diabetes | Endocrinology | Esophagus Cancer | Fatty Liver Disease (FLD) | Gastric (Stomach) Cancer | Liver | Liver Disease | Non-alcoholic Fatty Liver Diseases (NAFLD) | Obstructive Sleep Apnea | Pancreas | Pancreatic Cancer | Sleep Apnea | Sleep Disorders | Sleep Medicine | Smokers | Statistics | Study | Training | Universities & Medical Training | Urology & Nephrology