Clinical significance of a pvrl 4 encoded gene Nectin-4 in metastasis and angiogenesis for tumor relapse

ConclusionOur study demonstrated a significant correlation between Nectin-4 expression and tumor grade as well as stages (p <  0.001), suggesting its association with tumor progression. Nectin-4 was overexpressed at all stages of metastasis and angiogenesis, thus appearing to play a major role in tumor relapse through the PI3K–Akt–NFκβ pathway.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research