Molecule limits heart attack damage in mice

Conclusion This laboratory-based research in mice, which used a simulation designed to mimic the effects of a heart attack, appears to show that the molecule MitoSNO can prevent some of the heart tissue damage of a heart attack and the consequences of the return of blood to the heart (reperfusion). It is important to remember this was a small, early study in mice. Further studies in rodents would be needed to confirm these initial findings as true and accurate. Furthermore, this study was carried out in mice and the results may not be the same for people. Research in humans would be needed to understand fully the human biological processes involved and to establish whether MitoSNO is effective or safe when used in a similar way for real people. These experiments would need to include a rigorous assessment of the safety of the molecule. Despite the limitations, this intriguing research does highlight a potential biological target for further research. Ultimately, researchers hope to harness the protective effects of MitoSNO to reduce the damage in, and therefore aid the recovery of, people who have recently suffered heart failure due to lack of oxygen. Heart failure can have a significant adverse impact on quality of life so any treatment that can prevent or repair damage to the heart would be very valuable. Analysis by Bazian. Edited by NHS Choices. Follow Behind the Headlines on Twitter. Links To The Headlines Heart attack drug may reduce tissue damage. BBC News, May 27 201...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news

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We report an integrated genomic study of 25 tumour tissues from radical prostatectomy of aggressive (defined by International Society of Urological Pathology ≥3) prostate cancer patients (10 African Caribbean and 15 French Caucasian) using single nucleotide polymorphism arrays, whole-genome sequencing, and RNA sequencing. The results show that African Caribbean tumours are characterised by a more frequent deletion at 1q41-43 encompassing the DNA repair gene PARP1, and a higher proportion of intrachromosomal rearrangements including duplications associated with CDK12 truncating mutations. Transcriptome analyses show an o...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 22 September 2018Source: Journal of Visceral SurgeryAuthor(s): C. Chater, A. Saudemont, P. ZerbibSummaryRadiation enteritis is an iatrogenic disease of the intestines caused by radiation therapy. Two entities, chronic and acute radiation enteritis, are described. The acute symptoms (abdominal pain, loss of appetite, diarrhea) develop within the first hours or days after radiation therapy and can be treated medically. Chronic radiation enteritis leads to a chronic sub-obstructive and/or malabsorption syndrome developing at least two months after the end of radiation therapy. Cases occurrin...
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
This study examines the relationship between anxiolytic medications (AXM) on outcomes following ventral hernia repair.MethodsA single-center review of prospectively obtained perioperative and 30-day outcome data, including AXM use at admission, as part of the National Surgery Quality Improvement Program.ResultsSixty-three of the 393 patients who presented for ventral hernia repair were taking an AXM (15.6%). AXM users were more likely to have a higher ASA class, dyspnea, and treated hypertension (p 
Source: Hernia - Category: Sports Medicine Source Type: research
AbstractPurposeTreatment of chronic mesh infections (CMI) after parietal repair is difficult and not standardized. Our objective was to present the results of a standardized surgical treatment including maximal infected mesh removal.MethodsPatients who were referred to our center for chronic mesh infection were analyzed according to CMI risk factors, initial hernia prosthetic cure, CMI characteristics and treatments they received to achieve a cure.ResultsThirty-four patients (mean age 54  ± 13 years; range 23–72), were included. Initial prosthetic cure consisted of 26 incisional hernias and ...
Source: Hernia - Category: Sports Medicine Source Type: research
This study examined the outcomes of umbilical hernia repair in patients with advanced liver disease and compared this with a control group of non-cirrhotic patients.MethodsProspective data were collected regarding the outcome of umbilical hernia repairs performed between 2004 and 2013 at the Austin Hospital, Melbourne, Australia. Outcomes at 90  days were compared between patients with and without cirrhosis.Results79 patients with cirrhosis and 249 controls were analysed. Of the patients with cirrhosis, 9% were classified as Child –Pugh A, 61% were Child–Pugh B and 30% were Child–Pugh C. Emergency re...
Source: Hernia - Category: Sports Medicine Source Type: research
ConclusionsSignificant suspicion should be raised that life saving drugs such as heparin and bivalirudin could join forces with concurrent medication acting as antigens and induce fulminant and fatal stent thrombosis as a manifestation of Kounis syndrome
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
ARTHRITIS causes pain, inflammation and stiffness of certain joints. The most common types are osteoarthritis and rheumatoid arthritis, but there are also other types. Watch out for these five, lesser known types of the painful joint condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 21 September 2018Source: Revista Brasileira de Ortopedia (English Edition)Author(s): Glaucus Cajaty Martins, Luiz Felippe Martins Filho, Andre Heringer Raposo, Raphael Barbosa Gamallo, Zarthur Menegazzi, Antônio Vítor de AbreuAbstractObjectiveTo evaluate the prevalence of pain and radiographic degenerative arthritis in a group of severe obese patients (body mass index [BMI] > 35).Methods41 patients with an indication of bariatric surgery were studied. The group of severely obese patients was subdivided into two subgroups: those with BMI  50 (n =&nb...
Source: Revista Brasileira de Ortopedia - Category: Orthopaedics Source Type: research
ConclusionThe use of the collagen I/III porcine membrane was favorable for the treatment of chondral and osteochondral lesions of the knee when assessing the results using the VAS, Lysholm, and Kujala scores 1 year after surgery, as well as when assessing the magnetic resonance image of the lesion 6 months after surgery.ResumoObjetivosAvaliar os resultados clínicos e funcionais dos pacientes com diagnóstico de lesões condrais de espessura total em joelhos sintomáticos submetidos a um método de reparação biológica por meio da técnica de condrogênese aut&oa...
Source: Revista Brasileira de Ortopedia - Category: Orthopaedics Source Type: research
We report a case of a pyomyoma in which in-bag morcellation allowed for a total laparoscopic hysterectomy instead of laparotomy, which has been recognized as the standard of care to avoid the spread of infection from morcellation. A 45-year-old multiparous woman presented with sepsis, pelvic pain, and leukocytosis at 1 month after undergoing uterine artery embolization for symptomatic uterine leiomyoma. Pelvic computed tomography scan revealed a 9-cm suspected pyomyoma. A total hysterectomy was performed using a laparoscopic approach with in-bag morcellation. The intervention was successful, and the postoperative course wa...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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