What Does the Future Hold for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis?

What Does the Future Hold for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis? Curr Vasc Pharmacol. 2019;17(5):425-428 Authors: Doumas M, Imprialos K, Stavropoulos K, Athyros VG Abstract Non-Alcoholic Fatty Liver Disease (NAFLD), the most common liver disease, is characterized by accumulation of fat (>5% of the liver tissue), in the absence of alcohol abuse or other chronic liver diseases. Its prevalence is increasing because of obesity, metabolic syndrome or Type 2 Diabetes Mellitus (T2DM). NAFLD can cause liver inflammation and progress to Non-Alcoholic Steatohepatitis (NASH), fibrosis, cirrhosis or Hepatocellular Cancer (HCC). Nevertheless, Cardiovascular Disease (CVD) is the most common cause of morbidity and mortality in NAFLD/NASH patients. Current guidelines suggest the use of pioglitazone both in patients with T2DM and in those without. The newer antidiabetic drugs such as Glucagon Like Peptide-1 Receptor Agonists (GLP-1 RA), Sodium-Glucose co- Transporter-2 inhibitors (SGLT2i), and statins plus ezetimibe, are considered safe by the guidelines, and may have a beneficial effect on NAFLD/NASH as well as Cardiovascular Disease (CVD) morbidity and mortality. Future drugs seem to have a potential for holding down the evolution of NAFLD and reduce liver- and CVD-related morbidity and mortality, but they will take some years to be approved for routine use. Until then pioglitazone, GLP-1 RA, SGLT2i, and statins plus ezetimibe, espe...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research

Related Links:

Publication date: Available online 14 September 2019Source: Molecular Genetics and MetabolismAuthor(s): Róisín M. Boggan, Albert Lim, Robert W. Taylor, Robert McFarland, Sarah J. PickettAbstractMitochondrial diseases, caused by mutations in either the nuclear or mitochondrial genomes (mtDNA), are the most common form of inherited neurometabolic disorders. They are remarkably heterogeneous, both in their clinical presentation and genetic etiology, presenting challenges for diagnosis, clinical management and elucidation of molecular mechanism. The multifaceted nature of these diseases, compounded by the unique ...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
ConclusionNSM and SSM patients have similar reoperation rates and LOS; however, complication rate is higher in NSM patients.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Abstract BACKGROUND: In the past years numerous studies have investigated the efficacy of baclofen for alcohol dependence. After publication of several reviews a number of new randomized controlled trials have been published. Two recent meta-analyses, based on largely the same studies, reported contrary results. One meta-analysis showed a positive effect on time to relapse and abstinence at endpoint. The other meta-analysis did not show an effect on the primary outcome measures. AIM: To clarify the clinical relevance of the effect of baclofen on alcohol use in patients with a disorder in the use of alcohol, in the...
Source: Tijdschrift voor Psychiatrie - Category: Psychiatry Authors: Tags: Tijdschr Psychiatr Source Type: research
Publication date: Available online 14 September 2019Source: Journal of Advanced ResearchAuthor(s): Simone Kumstel, Praveen Vasudevan, Rupert Palme, Xianbin Zhang, Edgar Heinz Uwe Wendt, Robert David, Brigitte Vollmar, Dietmar ZechnerAbstractProspective severity assessment is legally required in many countries to ensure high-quality research along with high welfare standards for laboratory animals. Mice and rats, the most common laboratory species, are prey animals that usually suppress signs of pain and suffering. Therefore, highly sensitive readout parameters are necessary to adequately quantify distress. The present stud...
Source: Journal of Advanced Research - Category: Research Source Type: research
Authors: Reinert T, Coelho GP, Mandelli J, Zimermann E, Zaffaroni F, Bines J, Barrios CH, Graudenz MS Abstract Mutations in the ESR1 gene (ESR1m) are important mechanisms of resistance to endocrine therapy in estrogen receptor-positive advanced breast cancer and have been recognized as a prognostic and predictive biomarker as well as a potential therapeutic target. However, the prevalence of ESR1m in real-world patients has not been adequately described. Therefore, we sought to evaluate the prevalence of ESR1m in metastatic samples from Brazilian patients with estrogen receptor-positive (ER+) advanced breast cancer...
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
Publication date: Available online 13 September 2019Source: Social Science &MedicineAuthor(s): Piper SledgeAbstractIn this paper, I draw on the narratives of 57 individuals whose gender identities and decisions about their bodies trouble the medical protocols for breast and gynecological cancer care. I focus here on the decision-making process for three groups of elective surgeries: hysterectomy, prophylactic bilateral and contralateral mastectomy, and breast reconstruction. These elective surgeries illustrate places in medical interactions where patients and providers rely on frames of gender to determine whether a gi...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
In this study we investigated these questions using eye-tracking and a two alternative forced food-choice task after measuring subjective values (attitude extremity) and their accompanying accessibility, certainty, and stability. Understanding this basic decision-making process is key if we are to gain insight on how to combat societal problems like obesity and other issues related to diet. We found that participants allocated more attention to items with lower attitude accessibility, but tended to choose items with higher attitude accessibility. Higher attitude certainty and stability had no effects on attention, but led ...
Source: Journal of Experimental Social Psychology - Category: Psychiatry & Psychology Source Type: research
ConclusionResults of our study highlighted the possible role of fat in breast cancer progression suggesting a negative prognostic value of IDFi.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionsCurrent study evidently demonstrates that the anti-hypercholesterolemic effects of HS are mediated through redox-sensitive modulation of inflammatory pathways.Graphical abstract
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
In conclusion, BetaSweet carrots exhibits multiple health benefits to use as functional foods.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
More News: Actos | Alcoholism | Cancer | Cancer & Oncology | Cardiology | Cardiovascular | Cholesterol | Cirrhosis | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Drugs & Pharmacology | Eating Disorders & Weight Management | Endocrinology | Fatty Liver Disease (FLD) | Heart | Liver | Liver Disease | Metabolic Syndrome | Non-alcoholic Fatty Liver Diseases (NAFLD) | Obesity | Sodium | Statin Therapy | Substance Abuse | Urology & Nephrology | Vytorin | Zetia