Anxiety and Levodopa Equivalent Daily Dose Are Potential Predictors of Sleep Quality in Patients With Parkinson Disease in Taiwan

Conclusion: Poor sleepers constituted approximately half of our patients with PD. The participants experienced more favorable sleep if they were currently working. Increased PD duration, severity, depression or anxiety symptoms, and doses of dopaminergic therapy were significantly associated with poor sleep quality. Continued working, attempts to treat comorbid anxiety or depression, and avoidance of overdosage of dopaminergic treatments may improve sleep quality in patients with PD. Introduction Non-motor symptoms of Parkinson disease (PD) have gained increasing research attention in recent years because they have a greater negative impact on quality of life (QoL) compared with motor disabilities (1) and exhibit a relatively poor response to dopaminergic therapy due to the diverse underlying mechanisms (2). Among them, sleep disturbance is a common symptom, with an estimated prevalence of 45–90% in the population with PD (3, 4). Sleep disturbance not only contributes to an increased occurrence of other non-motor symptoms of PD but is also associated with a decline in QoL (5). Extensive assessments of sleep disturbance and identification of causative factors may help improve QoL in patients with PD. Polysomnography is considered the gold standard for the diagnosis of sleep disorders (6, 7); however, it is often reserved for patients with severe symptoms because of its low accessibility and high cost. Scales are more suitable assessment tools in clinics or at the...
Source: Frontiers in Neurology - Category: Neurology Source Type: research