Giving cancer patients a voice

Far too often, cancer patients and their doctors aren ’t aware of all the side effects that accompany new cancer therapies. Some of these new medications might cause fatigue, muscle aches, general pain and discomfort. A lack of information can lead to patients being unprepared to manage their symptoms or even cause some to delay or stop treatment all together. Historically, many clinical trials did not have a method to analyze or widely report the patient’s experience while undergoing a therapy.  Researchers at UCLA and across the country are trying to change that. To help people in making better-informed treatment decisions, these researchers are studying better ways to describe the patient experience while receiving cancer treatments. The goal is to provide more accurate information about the degree to which a drug can cause side effects. This information is collected by including the patient ’s own assessment of their experience.The research, which is supported with a $3.4 million grant from the National Cancer Institute, will develop improved ways to describe the results of clinical treatment trials where both expert and patient reports have been collected. This research is being funded by NCI ’s Cancer Moonshot to accelerate cancer research. It will allow four independent research groups to collaborate after they do their own independentprojects.Dr. Patricia Ganz, director of cancer prevention and control research at the UCLA Jonsson Comprehe...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Conclusion: Treatment of systemic loxoscelism involves aggressive supportive care including appropriate wound management, blood transfusions, intravenous fluid replacement, and appropriate antibiotic coverage. It is unclear at this time if glucocorticoids or IVIg has any beneficial impact on the treatment of severe loxoscelism. PMID: 31015839 [PubMed]
Source: Advances in Hematology - Category: Hematology Tags: Adv Hematol Source Type: research
This study examined how two aesthetic features of infographics affect people's evaluation of information presented in infographic: colour and visual complexity. The findings suggested colour and visual complexity were both strong predictors of information evaluation in infographic and they should be chosen carefully in the design of infographics. PMID: 31014148 [PubMed - as supplied by publisher]
Source: Journal of Visual Communication in Medicine - Category: Information Technology Tags: J Vis Commun Med Source Type: research
In conclusion, it was identified that silencing of miR‑193a‑3p through hypermethylation can promote HER2 positive breast cancer progress by targeting GRB7, ERK1/2 and FOXM1 signaling. The function of miR‑193a‑3p in HER2 positive breast cancer implicates its potential application in therapy. PMID: 31017268 [PubMed - in process]
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
MicroRNA‑576‑3p inhibits the migration and proangiogenic abilities of hypoxia‑treated glioma cells through hypoxia‑inducible factor‑1α. Int J Mol Med. 2019 Jun;43(6):2387-2397 Authors: Hu Q, Liu F, Yan T, Wu M, Ye M, Shi G, Lv S, Zhu X Abstract The most common and aggressive type of brain cancer in adults is glioblastoma multiforme (GBM), and hypoxia is a common feature of glioblastoma. As the histological features of glioma include capillary endothelial cell proliferation, they are highly prone to invading the surrounding normal brain tissue, which is often one of the reasons for the ...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
(CNN) — Alzheimer’s disease. Diabetes. Arthritis. Unwanted hair growth. Baldness. Infertility. Erectile dysfunction. Hangovers. Glaucoma. Cancer. If you have an ailment, there’s a good chance that someone, somewhere, is studying whether turmeric can treat it. There are more than 15,000 manuscripts published about curcumin, the active ingredient in turmeric, and about 50 manuscripts added to this collection each week, according to the National Institutes of Health. “It’s really taken on sort of panacea-like properties in terms of the things it’s being studied for and the things it has bee...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Local TV turmeric Source Type: news
As The Author of Minding Our Elders: Caregivers Share Their Personal Stories, I'm honored to be chosen to be part AlzAuthors. This post is courtesy of AlzAuthors. Read through for some incredible deals on ebooks written by authors who've been where you are. MOE is among the books on sale. All are $2.99 or less. November is National Caregiver Appreciation Month, a time to recognize the long hours, sacrifice, and love all caregivers bring to the task of caring for a loved one with dementia or any long-term illness. In honor of their efforts, AlzAuthors is hosting an eBook sale and giveaway! This is a terrific way f...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
In this study, we focused on two pathways of cardiomyocytes or heart cells: the Hippo pathway, which is involved in stopping renewal of adult cardiomyocytes, and the dystrophin glycoprotein complex (DGC) pathway, essential for cardiomyocyte normal functions." Previous work had hinted that components of the DGC pathway may somehow interact with members of the Hippo pathway. The researchers genetically engineered mice to lack genes involved in one or both pathways, and then determined the ability of the heart to repair an injury. These studies showed for the first time that dystroglycan 1, a component of the DGC ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
By MICHEL ACCAD, MD Jim was at his desk, looking weary. The last few weeks had been brutal.  Despite working twelve-hour days, he felt that he had little to show for it.  His annual board meeting was to take place the next day, and he expected it to be tense. With a replacement bill for the ACA about to be voted on, and with Trump in the White House, the situation seemed particularly precarious.  The board members had asked him to present a contingency plan, in case things in DC didn’t go well. As CEO of a major health insurance company, Jim was well aware that business as usu...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized AHCA health reform MICHEL ACCAD repeal and replace Source Type: blogs
In this study we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)-based epigenome editing to alter cell response to inflammatory environments by repressing inflammatory cytokine cell receptors, specifically TNFR1 and IL1R1. This has applications for many inflammatory-driven diseases. It could be applied for arthritis or to therapeutic cells that are being delivered to inflammatory environments that need to be protected from inflammation." In chronic back pain, for example, slipped or herniated discs are a result of damaged tissue when inflammation causes cells to create ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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