Salivary biomarkers detection: Analytical and immunological methods overview

Publication date: Available online 23 February 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Ioana Tiuca Gug, Mihaela Tertis, Oana Hosu, Cecilia CristeaAbstractSaliva is a complex matrix that reflects hormonal, immunological, metabolic and nutritional state of a person. Moreover, it is considered the most appropriate biological fluid for scientific investigations regarding ethics. Saliva chemistry is an emerging field and mostly employed in toxicology and forensic medicine for analysing and detecting user drug addiction and alcohol abuse by mapping the blood and saliva data. The advantages of salivary testing include helping in the diagnosis, prognosis and surveillance of disease, alongside with the non-invasive and ease of collection properties.The need for fast, cost-effective and reliable methods for saliva investigation has led to high technological advances in developing sensing tools. Hence, increasing number of papers are reporting diseases signalling salivary biomarkers for local or systemic pathologies like oral cancer, endocrine and immunologic pathologies, infectious and neurological diseases etc.This review focuses on the recent advances and main challenges employed in the detection and quantification of salivary biomarkers by separation, immunological and electrochemical techniques and highlight the future perspectives of the point-of-care devices in diagnosing local or systemic pathologies.

Source: TrAC Trends in Analytical Chemistry - February 23, 2019 Category: Chemistry Source Type: research