Dispersive liquid-liquid microextraction coupled with derivatization: a review of different modes, applications, and green aspects
Publication date: Available online 17 July 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Muhammad SajidAbstractDLLME is widely used as a sample preparation technique due to its unique advantages of fast extraction, low solvent consumption, high enrichment factors, and low cost. DLLME extracts are generally analyzed by gas or liquid chromatography coupled with different detection systems. However, GC or LC cannot analyze/separate many analytes due to their structural properties. Similarly, some of the analytes are not sensitive to commonly used detectors. In such cases, a derivatization process (chemical convers...
Source: TrAC Trends in Analytical Chemistry - July 19, 2018 Category: Chemistry Source Type: research

Instantaneous identification of hazardous explosive-related materials using laser induced photoacoustic spectroscopy
Publication date: Available online 17 July 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Yasser H. El-Sharkawy, Sherif Elbasuney, Ashraf El-sherif, Mohamed Eltahlawy, H.S. AyoubAbstractCommon fertilizers have the oxidizing and the reducing elements on the same molecule; therefore they have an explosiveness nature. Reliable approach for fast recognition of such compounds is an urgent need. Laser induced photoacoustic spectroscopy is an interesting technology as it can offer characteristic thermal, acoustical, and light absorption coefficient. The paper deals with a photoacoustic spectroscopy technique to record ...
Source: TrAC Trends in Analytical Chemistry - July 19, 2018 Category: Chemistry Source Type: research

Capillary Electrophoresis and Asymmetric Flow Field-Flow Fractionation for Size-based Separation of Engineered Metallic Nanoparticles: A Critical Comparative Review
Publication date: Available online 18 July 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Thilak K. Mudalige, Haiou Qu, Desiree Van Haute, Siyam M. Ansar, Sean W. LinderAbstractIn the characterization of nanomaterials, size and size distribution are among the most important parameters. A high-resolution technique is essential for the accurate determination of size distribution for a polydisperse nanoparticle suspension. Although there are many size-based separation techniques available for this purpose, the open channel designs of capillary electrophoresis (CE) and asymmetric flow field-flow fractionation (AF4) ...
Source: TrAC Trends in Analytical Chemistry - July 19, 2018 Category: Chemistry Source Type: research

Recent progressive preparations and applications of the SERS substrates based on silver
Publication date: Available online 12 July 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Qing Tong, Weijia Wang, Yining Fan, Lin DongAbstractIn recent years, considerable interest has been focused on the development of novel surface-enhanced Raman spectroscopy (SERS) techniques. Previous studies have shown that the structures of the substrates are critical for taking advantage of strong Raman signal enhancement. This review summarizes the recent trends and developments of SERS substrates with various structures and their applications based on silver. (Source: TrAC Trends in Analytical Chemistry)
Source: TrAC Trends in Analytical Chemistry - July 12, 2018 Category: Chemistry Source Type: research

Multiplexed immunochemical techniques for the detection of pollutants in aquatic environments
Publication date: September 2018Source: TrAC Trends in Analytical Chemistry, Volume 106Author(s): Ana Sanchis, J.-Pablo Salvador, M.-Pilar MarcoAbstractThe present article gives an overview of the situation of the aquatic ecosystem in respect to contamination by chemical pollutants and the different multiplexed techniques used to detect, identify and quantify water pollutants. A brief comparison between chromatographic and immunochemical methods is described at the beginning of this article, as an introduction of the increasing interest for multidetection of pollutants in these environments. The information regarding multi...
Source: TrAC Trends in Analytical Chemistry - July 12, 2018 Category: Chemistry Source Type: research

Recent advances in modulator technology for comprehensive two dimensional gas chromatography
Publication date: Available online 5 May 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): H. Daniel Bahaghighat, Chris E. Freye, Robert E. SynovecAbstractOne of the greatest advancements in the field of gas chromatography (GC) has been the development of comprehensive two-dimensional gas chromatography (GC × GC). As the field of GC evolved from one-dimensional gas chromatography (1D-GC) to heart cutting (GC–GC), followed by the advent of GC × GC, the critical component at the center of this evolution has been the interface between the separation columns. The interface, referre...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Characterization of odorant patterns by comprehensive two-dimensional gas chromatography: A challenge in omic studies
Publication date: Available online 14 June 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Chiara Cordero, Johannes Kiefl, Stephen E. Reichenbach, Carlo BicchiAbstractSensomics, like other “omics” fields, cuts across chemistry and biology and so requires holistic strategies capable of comprehensively mapping the set of all potential ligands (e.g., sensometabolome) that trigger the multimodal perception of food flavor. These complex mixtures when directed to odor receptors in the nose, define the so-called Chemical Odor Code. Analytical chemistry is challenged to comprehensively map the complex volatil...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Conformational Analysis of Complex Protein States by Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS): Challenges and Emerging Solutions
Publication date: Available online 27 June 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Esben Trabjerg, Zeinab E. Nazari, Kasper D. RandAbstractHydrogen/deuterium mass spectrometry (HDX-MS) has within the last 25 years evolved to become a well-established technique for analysing the solution-phase conformational dynamics and molecular interactions of proteins, attributes that can be difficult to access by other methods for structural analysis. This reviews present the latest development within HDX-MS with a special focus on how improvements in instrumentation, methodology and data analysis have expanded the ca...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Liquid-phase microextraction – The different principles and configurations
Publication date: Available online 30 June 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Yadollah Yamini, Maryam Rezazadeh, Shahram SeidiAbstractLiquid-phase microextraction is a miniaturized form of traditional liquid–liquid extraction in which the extracting organic phase is limited to a few microliters for extraction of target analytes. Despite the advantages of solid-phase microextraction, liquid-phase microextraction was also rapidly become a popular method due to its unique characteristics. Different liquid-phase microextraction systems have been introduced in order to simplify the extraction approa...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Multi-column trajectory to advanced methods in comprehensive two-dimensional gas chromatography
Publication date: Available online 30 June 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Yada Nolvachai, Chadin Kulsing, Khan M. Sharif, Yong Foo Wong, Sung-Tong Chin, Blagoj Mitrevski, Philip J. MarriottAbstractComprehensive two-dimensional gas chromatography (GC × GC) and multidimensional GC (MDGC) offer high performance separation capability towards multi-component samples, and improved sample characterisation. Recent advances, particularly with new GC × GC methodologies, which apply additional columns to GC × GC, along with hyphenation with mass spectrometry, ...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Advances in mass spectrometry for iron speciation in plants
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): Ghaya AlChoubassi, Justyna Aszyk, Paulina Pisarek, Katarzyna Bierla, Laurent Ouerdane, Joanna Szpunar, Ryszard LobinskiAbstractIron is an important nutrient essential for plants and critical for human health. The state-of-the art of methods for iron speciation in cereal grains and plant fluids is critically reviewed. Particular attention is given to the latest developments in the coupling of HPLC with the parallel ICP MS and electrospray ionization (ESI) MS/MS detection, usually QTOF MS or Q-Orbitrap MS, for the identification and ...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Advances in electrospray mass spectrometry for the selenium speciation: Focus on Se-rich yeast
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): Katarzyna Bierla, Simon Godin, Ryszard Lobinski, Joanna SzpunarAbstractSelenium is an essential element of which the deficiency is often compensated for by supplementation with products based on yeast grown on Se-rich media. Advances in HPLC with element- and molecule-specific detection by mass spectrometry have resulted in evidence of the presence of hundreds of selenocompounds in Se-rich yeast, with different properties and in a large concentration range. This spurs interest in extending –omics-type approaches to selenium s...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

The role of selenium in mercury toxicity – Current analytical techniques and future trends in analysis of selenium and mercury interactions in biological matrices
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): Zuzana Gajdosechova, Zoltan Mester, Jörg Feldmann, Eva M. KruppAbstractMercury forms potent toxic compounds, which cause irreversible damage to the central nervous system, while selenium, if present in an adequate concentration, is an essential micronutrient needed for the regulation of metabolic processes. The interactions between mercury and selenium have been rigorously scrutinized particularly due to observed protective effects of selenium against mercury toxicity, however very few proposed mechanisms are supported by empi...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Advanced metallomics methods in anticancer metallodrug mode of action studies
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): Hannah U. Holtkamp, Christian G. HartingerAbstractThe development of more potent metal-based drugs relies heavily on the understanding of their behavior in biological environments. Although the specific physicochemical properties of metal ions and their coordination compounds allow the application of element-specific techniques to track their fate after administration to a living organism, the ease of ligand exchanges makes speciation and target identification a challenge. In this review, we discuss selected examples of novel analy...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

High-performance liquid chromatography coupled to inductively coupled plasma – Mass spectrometry (HPLC-ICP-MS) for quantitative metabolite profiling of non-metal drugs
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): Balázs Klencsár, Sanwang Li, Lieve Balcaen, Frank VanhaeckeAbstractICP – (tandem) mass spectrometry or ICP-MS(/MS) is a well-known technique for ultra-trace element determination. It can also be used in the context of elemental speciation when combined as a sensitive element-specific detector with an adequate separation technique, e.g., (ultra)high-performance liquid chromatography ((U)HPLC). As the ICP-MS signal intensity is independent of the structure of the molecule the analyte element is present in, (U)HPLC...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Analysis of metal-based contrast agents in medicine and the environment
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): David Clases, Michael Sperling, Uwe KarstAbstractTechnetium (Tc) and Gadolinium (Gd) are the two most widely used metals in diagnostic medicine for scintigraphies and magnet resonance imaging (MRI), respectively. They play a crucial role for the generation or enhancement of contrast and are indispensable in countless diagnostic applications. However, the use of such contrast agents has caused severe health issues and environmental anomalies. This review aims to point out current issues and developments regarding the role and the an...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Advances in absolute protein quantification and quantitative protein mapping using ICP-MS
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): Laura Cid-Barrio, Francisco Calderón-Celis, Patricia Abásolo-Linares, M. Luisa Fernández-Sánchez, José Manuel Costa-Fernández, Jorge Ruiz Encinar, Alfredo Sanz-MedelAbstractProtein and peptide detection with inductively coupled plasma mass spectrometry (ICP-MS) can provide their direct and reliable absolute quantification without the need for specific standards, which greatly complements molecular mass spectrometry features in proteomics. We discuss recent research to shed new light on this...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

The importance of speciation analysis in neurodegeneration research
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): Bernhard Michalke, Desiree Willkommen, Evgenii Drobyshev, Nikolay SolovyevAbstractElement speciation offers deeper insight into the molecular mechanisms of disease by determining element species pattern. Thus, having great potential for investigating neurodegeneration in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and mild cognitive impairment, speciation is increasingly considered in epidemiological or clinical neurological studies. This review analyses recent speciation findings in neurodegeneration r...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

The crux of inept biomarkers for risks and benefits of trace elements
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): Julia Bornhorst, Anna P. Kipp, Hajo Haase, Sören Meyer, Tanja SchwerdtleAbstractNowadays, the role of trace elements (TE) is of growing interest because dyshomeostasis of selenium (Se), manganese (Mn), zinc (Zn), and copper (Cu) is supposed to be a risk factor for several diseases. Thereby, research focuses on identifying new biomarkers for the TE status to allow for a more reliable description of the individual TE and health status. This review mirrors a lack of well-defined, sensitive, and selective biomarkers and summarizes...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Editorial Board
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): (Source: TrAC Trends in Analytical Chemistry)
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Speciation of arsenic – A review of phenylarsenicals and related arsenic metabolites
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): Qingqing Liu, Xiufen Lu, Hanyong Peng, Aleksandra Popowich, Jeffrey Tao, Jagdeesh S. Uppal, Xiaowen Yan, Dana Boe, X. Chris LeAbstractEnvironmental and health studies of arsenic require the determination of arsenic species of diverse properties and toxicities. This review summarizes recent analytical advances in speciation of phenylarsenicals. Arsenic speciation techniques have taken advantage of high performance liquid chromatography (HPLC) separation with inductively coupled plasma mass spectrometry (ICPMS) and electrospray ioniz...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Trends on (elemental and molecular) mass spectrometry based strategies for speciation and metallomics
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): M. Montes-Bayón, M. Sharar, M. Corte-RodriguezAbstractThe capabilities of electrospray ionization (ESI) and matrix assisted laser desorption/ionization (MALDI) to permit species identification in combination with inductively coupled plasma (ICP) mass spectrometry to conduct element-tagged species monitoring have been exploited for a number of applications in speciation studies over the years. In this review, we report the new trends in the combined application of these techniques to address the structural and quantitative in...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Applications of liquid chromatography-inductively coupled plasma-mass spectrometry in the biosciences: A tutorial review and recent developments
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): David P. Bishop, Dominic J. Hare, David Clases, Philip A. DobleAbstractThe biological function of minor and trace elements is ordinarily determined by their association with specific proteins, peptides and other biomolecules. Therefore, measuring the total elemental content of a biological sample provides limited information, particularly when a specific effect is due to an individual metal-protein complex. Speciation of metalloproteins, heteroatom-containing molecules or other compounds tagged with an exogenous metal can be used t...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Advances in element speciation analysis of biomedical samples using synchrotron-based techniques
This article gives an overview of the basic principles of XAS and its application to element speciation in biomedical research. The basic principle and experimental modalities of XAS are introduced, followed by a discussion of both its limitations, such as beam damage or detection limits, and practical advices to improve experiments. An updated review of biomedical studies involving XAS published over the last 5 years is then provided, paying special attention to metal-based drug biotransformation, metal and nanoparticle toxicology, and element speciation in cancer, neurological, and general pathophysiology. Finally, trend...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Speciation of technologically critical elements in the environment using chromatography with element and molecule specific detection
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): Justyna Wojcieszek, Joanna Szpunar, Ryszard LobinskiAbstractThe growing release of technology-critical elements (TCEs): Ga, Ge, In, Nb, Ta, Te, Tl, and most of the platinum group elements (PGEs), and rare earth elements (REEs) requires the understanding of their mobility, reactivity and chemical transformations in the environment which are critically dependent on their chemical form (speciation). The total concentrations of these elements at the trace levels make their speciation analysis challenging. Coupled techniques combining a...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Critical assessment of hexavalent chromium species from different solid environmental, industrial and food matrices
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): F. Séby, V. VacchinaAbstractThe accurate determination of Cr(VI), the most hazardous form of chromium, is an analytical challenge because of its facility to be reduced during all steps of the analytical procedure. This review presents a synthesis of the available studies for the analysis of Cr species in different solid samples (soils/wastes, working atmosphere, industrial and food samples). A particular attention has been paid on Cr(III) and Cr(VI) interconversions that can occur during extraction and efforts made to avoid ...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Recent trends in element speciation analysis of crude oils and heavy petroleum fractions
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): Sara Gutiérrez Sama, Caroline Barrère-Mangote, Brice Bouyssière, Pierre Giusti, Ryszard LobinskiAbstractMedium and heavy crude oils and high-boiling distillation fractions which are increasingly used in petroleum industry contain high concentrations of sulfur and metals. Their behavior in refining processes is critically dependent on the speciation. Recent analytical developments, especially on the level of coupled techniques and high-resolution mass spectrometry, start allowing the speciation of individual met...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Advances in speciation techniques and methodology
Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): Michael Sperling, Uwe Karst (Source: TrAC Trends in Analytical Chemistry)
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

X-ray fluorescence analysis of milk and dairy products: a review
Publication date: Available online 3 July 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Galina V. Pashkova, Antonina N. Smagunova, Alexandr L. FinkelshteinAbstractA small mineral fraction substantially determines the nutrition value and quality of milk. The X-ray fluorescence spectrometry (XRF) is an expanding method in the field of elemental analysis of milk. Different configurations of XRF spectrometers are commercially available, and they are known as providing cheap and fast analyses of minerals and some trace elements with the accuracy and reproducibility required for food products. This research review pa...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Multiplexed immunochemical techniques for the detection of pollutants in aquatic environments
Publication date: Available online 4 July 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Ana Sanchís, J.-Pablo Salvador, M.-Pilar MarcoAbstractThe present article gives an overview of the situation of the aquatic ecosystem in respect to contamination by chemical pollutants and the different multiplexed techniques used to detect, identify and quantify water pollutants. A brief comparison between chromatographic and immunochemical methods is described at the beginning of this article, as an introduction of the increasing interest for multidetection of pollutants in these environments. The information regard...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

3D-Printed Miniaturized Fluidic Tools in Chemistry and Biology
Publication date: Available online 5 July 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): C.K. Dixit, K. Kadimisetty, J. RuslingAbstract3D printing (3DP), an additive manufacturing (AM) approach allowing for rapid prototyping and decentralized fabrication on-demand, has become a common method for creating parts or whole devices. The wide scope of the AM extends from organized sectors of construction, ornament, medical, and R&D industries to individual explorers attributed to the low cost, high quality printers along with revolutionary tools and polymers. While progress is being made but big manufacturing chal...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Comprehensive overview and recent advances in proteomics MS based methods for food allergens analysis
Publication date: Available online 5 July 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Linda Monaci, Elisabetta De Angelis, Nicola Montemurro, Rosa PilolliAbstractFood allergies are a serious health concern with increasing worldwide prevalence. Food legislation in place in several countries, requires detailed declaration of allergens in foods implying capability of methodologies to reliably trace food allergens. However, detecting and quantifying food allergens remains a challenge. Current common methods for food allergen analysis utilize antibody-based assays although some drawbacks are encountered such as ma...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Comprehensive Two-Dimensional Gas Chromatography in Environmental Analysis
Publication date: Available online 7 July 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Alina M. Muscalu, Tadeusz GóreckiAbstractComprehensive two-dimensional gas chromatography (GC×GC) offers increased peak capacity and selectivity relative to conventional one dimensional separations. The analysis of persistent organic pollutants in environmental matrices is very challenging due to the large number of compounds with varying chemical and physical properties that are typically present in the sample at the same time at concentrations ranging from ultra-trace to percent levels. GC×GC is steadily...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Dealing with strong mass interferences of chlorinated paraffins and their transformation products: An analytical guide
Publication date: Available online 7 July 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Lena Schinkel, Sandro Lehner, Norbert V. Heeb, Philippe Marchand, Ronan Cariou, Kristopher McNeill, Christian BogdalAbstractChlorinated paraffins (CPs) are high production volume chemicals. Their analysis is demanding and becomes even more challenging in presence of CP transformation products. Chlorinated olefins (COs) are expected thermal CP transformation products that are present in technical CP products and in the environment. Thus, a specific analysis of CPs and COs is important. Commonly, CPs are analysed by gas chroma...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Carbon nanomaterial-enabled pesticide biosensors: design strategy, biosensing mechanism, and practical application
Publication date: Available online 7 July 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Fengnian Zhao, Jian Wu, Yibin Ying, Yongxin She, Jing Wang, Jianfeng PingAbstractDue to overuse or abuse, pesticides can bring about severe residue problems, which will lead to potential toxicity for environment and human health. Consequently, it is of great importance to establish simple, rapid, robust, and reliable methods for monitoring pesticides. With outstanding properties like high electrical conductivity, catalytic activity, optical property, and favorable biocompatibility, carbon nanomaterials have been regarded as ...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Fabrication of Fluorescent Biosensing Platform Based on Graphene Oxide-DNA and Their Application in Biomolecule Detection
Publication date: Available online 9 July 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Si-Ying Wang, Chen-Feng Wang, Yun-Kai Lv, Shi-Gang ShenAbstractDuring the past few years, graphene oxide (GO) becomes increasingly significant in fluorescent biosensing due to its unique heterogeneous structure that offers it potential applications in various fields. Based on the transformation of affinities between GO and DNA, plenty of assays for bioanalysis have been developed rapidly, in which GO generally functions as a quencher. In this review, the current status and design mechanism of fluorescent biosensing platform ...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Nanomaterials for the sensing of narcotics: challenges and opportunities
Publication date: Available online 10 July 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): Vanish Kumar, Pawan Kumar, Anastasia Pournara, Kowsalya Vellingiri, Ki-Hyun KimAbstractIn recent years, nanomaterials have become a rapidly developing material technology due to their numerous advantages (e.g., high surface area, tunable surface structures, and advanced optical/electrical/mechanical features) and tremendous potential in biomedical, environmental, and energy applications. Here, we offer a comprehensive review on the advances, challenges, and opportunities of nanomaterial-based sensing technology for narcotic...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Recent advances in microfluidic models for cancer metastasis research
Publication date: August 2018Source: TrAC Trends in Analytical Chemistry, Volume 105Author(s): Hui Xu, Xinyao Liu, Weidong LeAbstractCancer metastasis is the process of tumour cells invading from the primary tumour site to other tissues or organs in the body, which significantly increases the morbidity and mortality of cancer patients. Conventional approaches to probe cancer metastasis have several limitations: (1) invasion assays based on petri dishes are of low physiological relevance and lack the specific character of the microenvironment; (2) transwell-based transmigration assays are only semi-quantitative; and (3) ani...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Advancement and prospects of bioinformatics analysis for studying bioactive peptides from food-derived protein: Sequence, structure, and functions
Publication date: August 2018Source: TrAC Trends in Analytical Chemistry, Volume 105Author(s): Maolin Tu, Shuzhen Cheng, Weihong Lu, Ming DuAbstractFood-derived bioactive peptides, as potential ingredients in health-promoting functional foods targeting diet-related chronic diseases, have attracted increasing attention because of their high biological activities, low toxicity, and easy of metabolism in human body. However, conventional methods for analyzing the bioactive peptides are not only expensive but also time-consuming; these drawbacks limited detailed studies and rapid development of bioactive peptides. Emerging bio...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Applications of ionic liquids in analytical chemistry with a particular emphasis on their use in solid-phase microextraction
Publication date: August 2018Source: TrAC Trends in Analytical Chemistry, Volume 105Author(s): Jakub Nawała, Barbara Dawidziuk, Daniel Dziedzic, Diana Gordon, Stanisław PopielAbstractNowadays, analytical research is an indispensable factor in the lives of people. Attempts are made to improve quality, speed or safety of analytical procedures. Recently, research on ionic liquids has become a trend. This is due to the possibility of their application in many fields. In this paper, the properties and diversity of ionic liquid application have been described, especially application in advanced analytical techniques such as va...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

On-field Raman spectroscopy of Patagonian prehistoric rock art: Pigments, alteration products and substrata
Publication date: August 2018Source: TrAC Trends in Analytical Chemistry, Volume 105Author(s): Anastasia Rousaki, Emmanuel Vargas, Cristina Vázquez, Verónica Aldazábal, Cristina Bellelli, Mariana Carballido Calatayud, Adam Hajduk, Oscar Palacios, Luc Moens, Peter VandenabeeleAbstractAn extensive in situ Raman spectroscopic campaign was performed on archaeological sites in three different provinces in Patagonia, Argentina (Neuquén, Río Negro and Chubut). 16 open air shelters located in different environments (forests, ecotones, steppes) were investigated and interpreted in terms of pigment...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Frontiers in highly sensitive molecularly imprinted electrochemical sensors: Challenges and strategies
Publication date: August 2018Source: TrAC Trends in Analytical Chemistry, Volume 105Author(s): Bin Yang, Cong Fu, Jianping Li, Guobao XuAbstractSensitivity is an important parameter of molecularly imprinted electrochemical sensors, and various methods have been extensively investigated to improve this parameter. This review focuses on recent reports about different methods that can enhance the sensitivity of these sensors. To a great extent, the sensitivity of the molecularly imprinted sensor is limited by the number of cavities formed in a molecularly imprinted polymer on an electrode after elution. To enhance sensitivity...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

From method validation to result assessment: Established facts and pending questions
Publication date: August 2018Source: TrAC Trends in Analytical Chemistry, Volume 105Author(s): Serge Rudaz, Max FeinbergAbstractThis paper aims to present a critical discussion of existing strategies to emphasize possible pitfalls and expected trends that arise from method validation to result assessment. It critically presents some aspects of the three main historical steps, namely terminology, method validation and quality of results. In addition to the formal link between method validation and measurement uncertainty that was recently demonstrated, the abundance of propositions also leads to some problems of consistency...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Recent advances in graphene-based freestanding paper-like materials for sensing applications
Publication date: August 2018Source: TrAC Trends in Analytical Chemistry, Volume 105Author(s): Yao Yao, Jianfeng PingAbstractThere has an increasing demand on the fabrication of flexible, light-weight, robust, cost-effective, and eco-friendly freestanding paper-like materials in view of their promising applications in energy devices, sensors, actuators, and chemical filters. With the unique planar structure and outstanding properties, graphene has been recognized as the most promising building block for the development of freestanding paper-like materials for various specific applications. Here, we highlight recent progres...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Determination of salivary cotinine as tobacco smoking biomarker
Publication date: August 2018Source: TrAC Trends in Analytical Chemistry, Volume 105Author(s): Adlin N. Ramdzan, M. Inês G.S. Almeida, Michael J. McCullough, Marcela A. Segundo, Spas D. KolevAbstractCotinine, the first metabolite of nicotine, is often used as a biomarker in the monitoring of environmental tobacco smoke (ETS) exposure due to its longer half-life. The use of saliva to measure the concentration of cotinine is an attractive alternative to conventional biological matrices (such as blood and urine) due to its simple and non-invasive collection method. However, the detection of minute concentrations of coti...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

How can analysts use multicriteria decision analysis?
Publication date: August 2018Source: TrAC Trends in Analytical Chemistry, Volume 105Author(s): Marta Bystrzanowska, Marek TobiszewskiAbstractProper decision making in multifacitated situation is very challenging task. It is especially difficult if there are many alternatives and criteria that are often contradictory. Analytical chemistry and related sciences involve many situations where decisions on complex problems are made. The support tools may be the use of MCDA (Multi-criteria Decision Analysis) algorithms. They formalize the decision process, make it transparent in all its aspects. In this review the application of ...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Recent progress on surface chemistry of plasmonic metal nanoparticles for colorimetric assay of drugs in pharmaceutical and biological samples
Publication date: August 2018Source: TrAC Trends in Analytical Chemistry, Volume 105Author(s): Suresh Kumar Kailasa, Janardhan Reddy Koduru, Mittal L. Desai, Tae Jung Park, Rakesh Kumar Singhal, Hirakendu BasuAbstractPlasmonic metal nanoparticles have been explored as a new class of chemical read-outs for assaying of a variety of chemical and biological species because of their unique physico-chemical and size dependent properties. Metal nanoparticles-based optical technologies are based on either new class of organic molecular assembly or with aggregation-induced optical changes features, which can also improve the sensit...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Recent trends in microextraction techniques used in determination of arsenic species
Publication date: August 2018Source: TrAC Trends in Analytical Chemistry, Volume 105Author(s): Justyna Werner, Tomasz Grześkowiak, Agnieszka Zgoła-Grześkowiak, Ewa StaniszAbstractThe determination of arsenic species is of great importance for human health, but it is still a challenge for analytical chemistry. Complete characterization of arsenic compounds is necessary due to different toxicological effects demonstrated by particular arsenic species. Modern analytical procedures include mainly usage of microextraction techniques which tend to reduce solvent consumption, e.g. liquid phase microextraction (LPME), or employ...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

In the pursuit of the holy grail of forensic science – Spectroscopic studies on the estimation of time since deposition of bloodstains
Publication date: August 2018Source: TrAC Trends in Analytical Chemistry, Volume 105Author(s): Grzegorz Zadora, Alicja MenżykAbstractBloodstains can serve as a source of high-value information, allowing for the reconstruction of bloodshed events or identification of the sample donor. However, from the forensic perspective, the evidential potential of blood traces is not fully exploited. This is because despite significant research efforts, to date, no reliable method for estimating time elapsed since bloodstain deposition has been established. Nonetheless, over the last few years (2011–2017), some noteworthy advance...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research

Explosive detection by Surface Enhanced Raman Scattering
Publication date: August 2018Source: TrAC Trends in Analytical Chemistry, Volume 105Author(s): Raymond Gillibert, Jiao Qi Huang, Yang Zhang, Wei Ling Fu, Marc Lamy de la ChapelleAbstractThe Surface Enhanced Raman Scattering (SERS) has demonstrated its high efficiency to increase the Raman signal of chemical and biological species and to be able to observe and identify a very low quantity of molecules paving the way to the single molecule sensitivity. Its application to molecular detection is now intensively developed to set-up various kind of highly sensitive sensors. In this paper, we propose a review on the SERS techniqu...
Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research