Comprehensive multidimensional liquid chromatography for advancing environmental and natural products research
This article presents a critical review on the most prominent of these comprehensive MDLC methods for targeted and untargeted analysis of complex environmental and natural products samples. This article also discusses the practical aspects of applying peak capacity and orthogonality concepts in MDLC analysis of complex matrices. It also addresses the limitations and challenges ahead for advancing environmental and natural products research using comprehensive MDLC. (Source: TrAC Trends in Analytical Chemistry)
Source: TrAC Trends in Analytical Chemistry - May 21, 2019 Category: Chemistry Source Type: research

Selecting an extraction solvent for a greener liquid phase microextraction (LPME) mode-based analytical method
Publication date: Available online 20 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): John M. KokosaAbstractLiquid phase microextraction (LPME) has become an increasingly important tool for environmental, pharmaceutical, food, clinical and industrial analysis laboratories. LPME (also referred to as solvent microextraction, SME) consists of three major micro solvent extraction modes, single drop microextraction (SDME), hollow fiber-liquid phase microextraction (HF-LPME) and dispersive liquid-liquid microextraction (DLLME), each of which has unique extraction solvent requirements. LPME, with greatly reduced sol...
Source: TrAC Trends in Analytical Chemistry - May 21, 2019 Category: Chemistry Source Type: research

Cell-based Drug Screening on Microfluidics
Publication date: Available online 20 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Jiao Zhai, Shuhong Yi, Yanwei Jia, Pui-In Mak, Rui P. MartinsAbstractWith the inherent merits of a low reagent consumption, the small amount of sample needed and easy integration, a wide variety of microfluidic platforms (continuous-flow, droplet, digital and paper) have been developed to address the challenges (e.g. throughput, single-cell isolation, cost and flexibility) of cell-based drug screening. This review essentially summarises the pros and cons of the platforms for different applications, so as to shed light on the...
Source: TrAC Trends in Analytical Chemistry - May 21, 2019 Category: Chemistry Source Type: research

Title: Analysis of hexafluoropropylene oxide-dimer acid (HFPO-DA) by Liquid Chromatography-Mass Spectrometry (LC-MS): Review of Current Approaches and Environmental Levels
Publication date: Available online 20 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Lauren Mullin, David Katz, Nicole Riddell, Robert Plumb, Jennifer A. Burgess, Leo W.Y. Yeung, Ingrid Ericson JogstenAbstractEmerging per- and polyfluorinated compounds (PFAS) compounds are of increasing interest for environmental monitoring, one being hexafluoropropylene oxide-dimer acid (HFPO-DA), commonly referred to as GenX. The following review describes existing liquid chromatography-mass spectrometry (LC-MS) methods used to analyze HFPO-DA, including sample preparation and method sensitivity relative to other PFAS. Ana...
Source: TrAC Trends in Analytical Chemistry - May 21, 2019 Category: Chemistry Source Type: research

Characterization of the binding of per- and poly-fluorinated substances to proteins: A methodological review
Publication date: Available online 20 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Xiaotu Liu, Mingling Fang, Fangping Xu, Da ChenAbstractPer- and poly-fluorinated substances (PFASs) are known to have the potential of binding to certain proteins. Protein binding is important to the understanding of cellular toxicities, biotransformation pathways, and the fate of selected PFASs. In this work, we provide a systematic review of major approaches to characterizing PFAS-protein binding, including the techniques based on separation, calorimetry, spectroscopy, mass spectrometry, surface plasmon resonance, molecula...
Source: TrAC Trends in Analytical Chemistry - May 21, 2019 Category: Chemistry Source Type: research

Microfluidic analysis of circulating tumor cells and tumor-derived extracellular vesicles
Publication date: Available online 20 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Fei Tian, Chao Liu, Ling Lin, Qinghua Chen, Jiashu SunAbstractLiquid biopsy of circulating tumor cells (CTCs) and tumor-derived extracellular vesicles (EVs) holds immense promise in early detection of cancer, monitoring efficacy of therapy, and predicting prognosis. Microfluidic techniques provide new tools for isolation and detection of CTCs and EVs, by offering a multitude of advantages in terms of high-level of integration, multiplex analysis, small sample consumption, and point-of-care testing. This review summarizes rec...
Source: TrAC Trends in Analytical Chemistry - May 21, 2019 Category: Chemistry Source Type: research

Development of electrochemical biosensors for tumor marker determination towards cancer diagnosis: Recent progress
Publication date: Available online 20 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Deniz Sadighbayan, Khosrow Sadighbayan, Mohammad Reza Tohid-kia, Ahmad Yari Khosroushahi, Mohammad HasanzadehAbstractAccording to the latest statistics, cancer is expected to account for nearly 1800000 new cases and about 607000 deaths in the US in 2019. Approximately 40% of people with cancer survive. This means that life expectancy is a little more than 1 in 3. Therefore, it is essential to detect this malignancy in early stage and predict therapeutic responses in patients in order to enhance the efficiency of treatment, d...
Source: TrAC Trends in Analytical Chemistry - May 21, 2019 Category: Chemistry Source Type: research

Advances in capillary electrophoresis-mass spectrometry for cell analysis
Publication date: Available online 18 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Wei Zhou, Baofang Zhang, Yikun Liu, Chenlu Wang, Wenqi Sun, Wen Li, Zilin ChenAbstractMass spectrometry has become a powerful tool in the field of bioanalysis. The combination of capillary electrophoresis with mass spectrometry (CE-MS) offers fast and high-resolution separation, sensitive and selective detection with small sample volumes, which is suitable for cell analysis. Here, we review the recent technical development of CE, MS and hyphenated strategies as well as their potential in cell analysis. In particular, we disc...
Source: TrAC Trends in Analytical Chemistry - May 19, 2019 Category: Chemistry Source Type: research

Recent advances in microfluidic platforms for single-cell analysis in cancer biology, diagnosis and therapy
Publication date: Available online 17 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Hamed Tavakoli, Wan Zhou, Lei Ma, Stefani Perez, Andrea Ibarra, Feng Xu, Sihui Zhan, XiuJun LiAbstractUnderstanding molecular, cellular, genetic and functional heterogeneity of tumors at the single-cell level has become a major challenge for cancer research. The microfluidic technique has emerged as an important tool that offers advantages in analyzing single-cells with the capability to integrate time-consuming and labour-intensive experimental procedures such as single-cell capture into a single microdevice at ease and in ...
Source: TrAC Trends in Analytical Chemistry - May 18, 2019 Category: Chemistry Source Type: research

The potential of nanomaterials in theranostics of oral squamous cell carcinoma: Recent progress
Publication date: Available online 15 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Elham Ahmadian, Solmaz Maleki Dizaj, Simin Sharifi, Shahriar Shahi, Rovshan Khalilov, Aziz Eftekhari, Mohammad HasanzadehAbstractOral squamous cell carcinoma (OSCC), a main type of oral cancer, is one of the main causes of morbidity and mortality worldwide. Subsequent to definite diagnosis of oral cancer, generally a multidisciplinary approach is used in OSCC treatment which consists of surgery, chemotherapy and radiation. However, conventional chemotherapeutic agents might be ineffective and induce different side effects. N...
Source: TrAC Trends in Analytical Chemistry - May 16, 2019 Category: Chemistry Source Type: research

Innovation on Separation and Characterization of Complex Samples: a Tribute to Prof. Dr. Hanfa Zou
Publication date: Available online 14 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Mingliang Ye, Lihua Zhang, Zhen Liu, Hailin Wang (Source: TrAC Trends in Analytical Chemistry)
Source: TrAC Trends in Analytical Chemistry - May 16, 2019 Category: Chemistry Source Type: research

Chromium removal from contaminated waters using nanomaterials – A review
Publication date: Available online 11 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Joana C. Almeida, Celso E.D. Cardoso, Daniela S. Tavares, Rosa Freitas, Tito Trindade, Carlos Vale, Eduarda PereiraAbstractCurrent environmental policies aim to reduce the levels of toxic substances in aquatic ecosystems and to promote the water reuse after appropriate treatment of wastewater. Chromium is a hazard element present in effluents of various industries that should be reduced to achieve the objectives of those policies. Most of the results reported in the literature concern the use of nanomaterials for chromium so...
Source: TrAC Trends in Analytical Chemistry - May 12, 2019 Category: Chemistry Source Type: research

Plasmonic nanostructure-based bioimaging and detection techniques at the single-cell level
Publication date: Available online 9 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Seungah Lee, Yucheng Sun, Yingying Cao, Seong Ho KangAbstractStudies on the properties of plasmonic materials and new chemical biological sensors are very important to our understanding of biological systems in single cells. Since the advent of nanofabrication techniques, plasmonic nanostructures have been widely used in various research fields including material science, biology, and medicine. The optical, electronic and catalytic properties of plasmonic nanostructures can be tuned very broadly by controlling their size, sha...
Source: TrAC Trends in Analytical Chemistry - May 11, 2019 Category: Chemistry Source Type: research

An overview of advanced methods for the characterization of oxygen vacancies in materials
Publication date: Available online 9 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Kaihang Ye, Kunshan Li, Yirui Lu, Zhongjie Guo, Nan Ni, Hong Liu, Yongchao Huang, Hongbing Ji, Pingshan WangAbstractOxygen vacancy plays an important role in many fields, such as photocatalysis, energy storages, electro-catalysis, which has been widely investigated both by experiment and theoretical calculations. Herein, this review presents the new type and advanced methods to detect the existence of oxygen vacancies in nanomaterials, such as, electron paramagnetic resonance, synchrotron radiation-based X-ray absorption fine...
Source: TrAC Trends in Analytical Chemistry - May 11, 2019 Category: Chemistry Source Type: research

Recent Advances in the Coupling of Carbon Dioxide-Based Extraction and Separation Techniques
Publication date: Available online 9 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Mariosimone Zoccali, Paola Donato, Luigi MondelloAbstractAny successful analytical method results from a flawless combination of at least three major steps, consisting of sample preparation, instrumental analysis, and data processing. Apart from selectivity and effectiveness, speed and cheapness obviously represent desirable features of any analytical methods and, to this regard, the use of carbon dioxide as a supercritical fluid offers unique opportunities for extraction and separation, with reduced time and solvent consumpt...
Source: TrAC Trends in Analytical Chemistry - May 11, 2019 Category: Chemistry Source Type: research

Sub- and supercritical fluid extraction of bioactive compounds from plants, food-by-products, seaweeds and microalgae – an update
Publication date: Available online 9 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Rocío Gallego, Mónica Bueno, Miguel HerreroAbstractFollowing our previous reviews, this manuscript presents an updated perspective on the use of compressed fluids, mainly under sub- and supercritical conditions, for the extraction of bioactive components from natural matrices covering the period from 2015 to present. These extraction technologies might have an important role in the development of sustainable and efficient extraction processes to cope with the high demand of natural bioactive compounds. Moreover,...
Source: TrAC Trends in Analytical Chemistry - May 11, 2019 Category: Chemistry Source Type: research

Current analytical approaches in diagnosis of melanoma
Publication date: Available online 9 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Aziz Eftekhari, Elham Ahmadian, Sara Salatin, Simin Sharifi, Solmaz Maleki Dizaj, Rovshan Khalilov, Mohammad HasanzadehAbstractThis review aims to explore applied variety methods for prognosis and diagnosis melanoma in early stages. The role of skin self-examination in early detection, the use of dreamscape tools, and some other techniques application for analyze of lesion (suspect for conatus melanoma) have been reviewed. Electrochemical and optical biosensors for melanoma detecting are also discussed. Besides, the advantage...
Source: TrAC Trends in Analytical Chemistry - May 11, 2019 Category: Chemistry Source Type: research

Aptamer-based microfluidics for isolation, release and analysis of circulating tumor cells
Publication date: Available online 9 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Lingling Wu, Lin Zhu, Mengjiao Huang, Jia Song, Huimin Zhang, Yanling Song, Wei Wang, Chaoyong YangAbstractThe analysis of circulating tumor cells (CTCs) holds great significance for cancer diagnosis, prognosis, and personalized therapy. However, the rarity, vulnerability and heterogeneity of CTCs bring daunting technical challenges to their isolation, release and analysis. Recent exciting advances in microfluidics have greatly promoted CTC isolation and analysis due to its merits of precise control of fluid behavior, integra...
Source: TrAC Trends in Analytical Chemistry - May 11, 2019 Category: Chemistry Source Type: research

Recent developments in microwave-induced plasma optical emission spectrometry and applications of a commercial Hammer-cavity instrument
Publication date: Available online 10 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Charles B. Williams, Bradley T. Jones, George L. Donati, Renata S. Amais, Beatriz M. Fontoura, Joaquim A. NóbregaAbstractMicrowave-induced plasma optical emission spectrometry (MIP OES) has increasingly become a major resource for multi-elemental analysis. One of the greatest breakthroughs in the field has been the development of a commercial instrument based on a Hammer cavity, which runs on N2 gas obtained from an air compressor and a N2 generator. Here, we describe the most recent advances in MIP OES instrumentatio...
Source: TrAC Trends in Analytical Chemistry - May 11, 2019 Category: Chemistry Source Type: research

Microwave-Assisted Extraction of pharmaceuticals, personal care products and industrial contaminants in the environment
Publication date: Available online 8 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Maria Llompart, Maria Celeiro, Thierry DagnacAbstractMicrowave-assisted extraction (MAE) is a well-established automated green extraction technique, offering many advantages such as the combined reduction of the extraction time, solvent and energy consumptions, as well as the possibility of performing simultaneous multiple extractions, thus increasing the number of samples processed daily. This review provides a comprehensive description of the most relevant analytical methods and applications, proposed from year 2012, for th...
Source: TrAC Trends in Analytical Chemistry - May 10, 2019 Category: Chemistry Source Type: research

Shining luminescent graphene quantum dots: synthesis, physicochemical properties, and biomedical applications
Publication date: Available online 7 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Xiliu Zhang, Changbo Wei, Ye Li, Dongsheng YuAbstractGraphene quantum dots (GQDs), among the graphene-based materials, possess distinct physical and electrochemical properties, including nano size, large surface-to-volume ratio, and low cytotoxicity, and have become a promising alternative in the field of biomedicine. Moreover, the integration of specific optical properties, that is, tunable photoluminescence and up-photoluminescence, has led to remarkable bioapplications in bioimaging, biosensors, and phototherapy. In this r...
Source: TrAC Trends in Analytical Chemistry - May 8, 2019 Category: Chemistry Source Type: research

Labile trace metal concentration measurements in marine environments: from coastal to open ocean areas
Publication date: Available online 6 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Yue Gao, Chunyang Zhou, Camille Gaulier, Arne Bratkic, Josep Galceran, Jaume Puy, Hao Zhang, Martine Leermakers, Willy BaeyensAbstractIn seawater, trace metals occur in many forms: free ion, labile and non-labile complex, colloid, associated with particles, but only free ions and very labile metal complexes can cross the phytoplankton membrane and be assimilated. In this paper we review the most appropriate determination methods for those metal species, addressing particularly in situ speciation and preconcentration. Focus is...
Source: TrAC Trends in Analytical Chemistry - May 7, 2019 Category: Chemistry Source Type: research

A review of the applications of Schiff bases as optical chemical sensors
Publication date: Available online 6 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Asnake Lealem Berhanu, Gaurav, Irshad Mohiuddin, Ashok Kumar Malik, Jatinder Singh Aulakh, Vanish Kumar, Ki-Hyun KimAbstractSchiff bases and their metal complexes have become well-known for catalytic (e.g., in various synthetic processes) and biological properties (e.g., antifungal, antibacterial, anti-malarial, and antiviral characteristics) since their discovery by Hugo Schiff in 1864. As synthetic compounds, they are employed as versatile tools in diverse applications such as fluorescent turn-on/turn-off sensors for the de...
Source: TrAC Trends in Analytical Chemistry - May 7, 2019 Category: Chemistry Source Type: research

Red-shifted Bioluminescence Resonance Energy Transfer: Improved tools and materials for analytical in vivo approaches
Publication date: Available online 6 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Felix Weihs, Helen Dacres (Source: TrAC Trends in Analytical Chemistry)
Source: TrAC Trends in Analytical Chemistry - May 7, 2019 Category: Chemistry Source Type: research

Recent Progress in Metabolomics using Ion Mobility-Mass Spectrometry
Publication date: Available online 4 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Allison J. Levy, Nicholas R. Oranzi, Atiye Ahmadireskety, Robin H.J. Kemperman, Michael S. Wei, Richard A. YostAbstractIn recent years, metabolomics and lipidomics approaches have become increasingly popular for use in the analysis of human heath, molecular mechanisms, and disease progression. Despite the growth in applications and advances in instrumentation, metabolomics and lipidomics are limited by factors including interference from matrix effects, the need for lengthy for chromatographic analysis, and structural diversi...
Source: TrAC Trends in Analytical Chemistry - May 4, 2019 Category: Chemistry Source Type: research

Ion Mobility Spectrometry and the Omics: Distinguishing Isomers, Molecular Classes and Contaminant Ions in Complex Samples
Publication date: Available online 29 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Kristin E. Burnum-Johnson, Xueyun Zheng, James N. Dodds, Jeremy Ash, Denis Fourches, Carrie D. Nicora, Jason P. Wendler, Thomas O. Metz, Katrina M. Waters, Janet K. Jansson, Richard D. Smith, Erin S. BakerAbstractIon mobility spectrometry (IMS) is a widely used analytical technique providing rapid gas phase separations. IMS alone is useful, but its coupling with mass spectrometry (IMS-MS) and various front-end separation techniques has greatly increased the molecular information achievable from different omic analyses. IMS...
Source: TrAC Trends in Analytical Chemistry - May 1, 2019 Category: Chemistry Source Type: research

Computational Insights into Compaction of Gas-Phase Protein and Protein Complex Ions in Native Ion Mobility-Mass Spectrometry
Publication date: Available online 30 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Amber D. Rolland, James S. PrellAbstractNative ion mobility-mass spectrometry (IM-MS) is a rapidly growing field for studying the composition and structure of biomolecules and biomolecular complexes using gas-phase methods. Typically, ions are formed in native IM-MS using gentle nanoelectrospray ionization conditions, which in many cases can preserve condensed-phase stoichiometry. Although much evidence shows that large-scale condensed-phase structure, such as quaternary structure and topology, can also be preserved, it is...
Source: TrAC Trends in Analytical Chemistry - May 1, 2019 Category: Chemistry Source Type: research

Opening new paths for biological applications of ion mobility - mass spectrometry using Structures for Lossless Ion Manipulations
Publication date: Available online 30 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Sandilya V.B. Garimella, Gabe Nagy, Yehia M. Ibrahim, Richard D. SmithAbstractIon mobility separations coupled to mass spectrometry (IM-MS) have received much attention for their ability to provide complementary structural information to solution-phase-based separations, as well as to aid in the identification of unknown compounds. While IM-MS is an increasingly powerful analytical technique, significant bottlenecks related to the resolution of measurements have kept it from becoming broadly applied for biological analyses...
Source: TrAC Trends in Analytical Chemistry - May 1, 2019 Category: Chemistry Source Type: research

Advanced nanomaterials towards biosensing of insulin: Analytical approaches
We report most recent advances in insulin detection from Jan 2010 to Feb 2019 with discussions on their advantages and limitations. The analytical figures of merit of the developed methods are also evaluated. (Source: TrAC Trends in Analytical Chemistry)
Source: TrAC Trends in Analytical Chemistry - April 25, 2019 Category: Chemistry Source Type: research

Protein post-translational modifications – a challenge for bioelectrochemistry
Publication date: Available online 19 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Elena V. SuprunAbstractPost-translational modifications (PTMs) occur during or after protein biosynthesis under the action of various specific enzymes or reactive oxygen and nitrogen species. These modifications affect a wide range of protein characteristics such as the size and charge of proteins, their activation state, enzyme activity, cellular localization, interacting partners, and life cycle. Imbalance in protein PTMs can lead to a development of various diseases, among them are cancer and diabetes. It is also genera...
Source: TrAC Trends in Analytical Chemistry - April 20, 2019 Category: Chemistry Source Type: research

Recent Advancements in Structural Improvements of Lateral Flow Assays towards Point-of-Care Testing
Publication date: Available online 17 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Tohid Mahmoudi, Miguel de la Guardia, Behnaz Shirdel, Ahad Mokhtarzadeh, Behzad BaradarnAbstractLateral flow assays (LFAs) provide some of the most attractive point-of-care instruments for broad applications with simple, rapid, user-friendly, and cost-effective characteristics. However, these technologies suffer from low sensitivity, poor limit of detection, and just qualitative or semi-quantitative results that restrict their practical applications. Extensive research has been reported in this area involving sensitivity e...
Source: TrAC Trends in Analytical Chemistry - April 19, 2019 Category: Chemistry Source Type: research

Elemental Characterization of Nuclear Materials using Total reflection X-Ray Fluorescence Spectrometry
Publication date: Available online 17 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Sangita Dhara, N.L. MisraAbstractThe present article gives an overview of the current state of applications of Total reflection X-Ray Fluorescence (TXRF) spectrometry for the analytical characterization of nuclear materials. The features of TXRF such as, requirement of very small sample amount, non consumptive and sometimes non-destructive nature of analysis, simple quantification methodology, negligible matrix and no memory effect, fast and simultaneous determination of almost all the elements of the periodic table includ...
Source: TrAC Trends in Analytical Chemistry - April 19, 2019 Category: Chemistry Source Type: research

Current trends in QuEChERS method. A versatile procedure for food, environmental and biological analysis TrAC- Special Issue “Green Extraction Techniques”
Publication date: Available online 17 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Álvaro Santana-Mayor, Bárbara Socas-Rodríguez, Antonio V. Herrera-Herrera, Miguel Ángel Rodríguez-DelgadoAbstractQuEChERS (quick, easy, cheap, effective, rugged, and safe) method was initially developed by Anastassiades and coworkers as an interesting alternative based on the main principles of the Green Chemistry to the determination of pesticides in fruit and vegetables. However, the great versatility of the procedure has allowed its application in other types of matrices and analytes w...
Source: TrAC Trends in Analytical Chemistry - April 19, 2019 Category: Chemistry Source Type: research

Functional solid-state nanochannels for biochemical sensing
Publication date: Available online 18 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Qun Ma, Zhixiao Si, Yu Li, Dagui Wang, Xiuling Wu, Pengcheng Gao, Fan XiaAbstractNanochannel typically serves as a passageway of ionic current, which can offer a rapid and highly sensitive output for biochemical sensing. Solid-state nanopores/channels, by virtue of their superior mechanical and chemical stability, well-adjustable structure, and easily tailorable surface properties, draw great attention in practical nanochannel-based sensor devices. Particularly, when functioned by diverse probes, solid-state nanochannel-ba...
Source: TrAC Trends in Analytical Chemistry - April 19, 2019 Category: Chemistry Source Type: research

Analysis of emerging per- and polyfluoroalkyl substances: progress and current issues
Publication date: Available online 16 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Yitao Pan, Jinghua Wang, Leo W.Y. Yeung, Si Wei, Jiayin DaiAbstractThe increasingly stringent restrictions on legacy per- and polyfluoroalkyl substances (PFASs) have led to the compensatory use of new fluorinated replacements. These new compounds, hereafter referred to as emerging PFASs, continue to be discovered and are now showing ubiquity in abiotic and biotic environments. Thus, there is an urgent need for robust, yet sensitive analytical methods to determine their occurrence and understand their behavior, fate, impact...
Source: TrAC Trends in Analytical Chemistry - April 17, 2019 Category: Chemistry Source Type: research

Oncolipidomics: Mass Spectrometric Quantitation of Lipids in Cancer Research
Publication date: Available online 16 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Denise Wolrab, Robert Jirásko, Michaela Chocholoušková, Ondřej Peterka, Michal HolčapekAbstractThis review summarizes available mass spectrometry (MS) based approaches for the quantitative analysis of lipids in biological samples in the cancer research, which is termed here as oncolipidomics. The methodological part shows possible configurations of stand-alone MS or MS coupled to liquid-phase separation techniques for the characterization of various lipids with the special emphasis on methods conveni...
Source: TrAC Trends in Analytical Chemistry - April 17, 2019 Category: Chemistry Source Type: research

Desorption electrospray ionization mass spectrometry for food analysis
Publication date: Available online 17 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Alessandra Gentili, Salvatore Fanali, Lucia Mainero RoccaAbstractDesorption electrospray ionization mass spectrometry (DESI-MS) has found applications in many fields. Unfortunately and despite many peculiarities, its use in food science is still in its infancy.This review focuses on both technical aspects and the different ways in which this interface has been exploited in food analysis. DESI signal’s reliance on interface geometry, solvent composition, and analyte distribution is deeply evaluated and microscopic pic...
Source: TrAC Trends in Analytical Chemistry - April 17, 2019 Category: Chemistry Source Type: research

Recent Advances in Biological Separations using Trapped Ion Mobility Spectrometry – Mass Spectrometry
Publication date: Available online 16 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Kevin Jeanne Dit Fouque, Francisco Fernandez-LimaAbstractIon Mobility Spectrometry (IMS) is a widely used technique for the post-ionization separation and structural characterization of biomolecules. Trapped IMS (TIMS) is a relatively recent advance in the field of linear IMS that has shown advantages for the study of biological problems when in tandem with mass spectrometry (TIMS-MS). TIMS’s unique nature of holding ions using an electric field against a moving buffer gas allows for the tuning of the mobility separa...
Source: TrAC Trends in Analytical Chemistry - April 16, 2019 Category: Chemistry Source Type: research

Online and in situ analysis of Organs-on-a-chip
Publication date: Available online 11 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Milou J.C. Santbergen, Meike van der Zande, Hans Bouwmeester, Michel W.F. NielenAbstractOrgan-on-a-chip technology is used to study biological processes that involve multiple cell types and temporal changes like, homeostasis, metabolism and responses to chemical triggers. Main benefits of organ-on-a-chip systems include: improved mimicking of the in-vivo situation, easy manipulation of the microenvironment and low reagent consumption. Exploiting unique dynamic aspects of organ-on-a-chip technology, such as liquid flow, aut...
Source: TrAC Trends in Analytical Chemistry - April 13, 2019 Category: Chemistry Source Type: research

Activity-Based Proteomic Profiling: The Application of Photoaffinity Probes in the Target Identification of Bioactive molecules
Publication date: Available online 11 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Jin Wang, Qinhua Chen, Yuanyuan Shan, Xiaoyan Pan, Jie ZhangAbstractIdentifying cellular targets for bioactive molecules is a major challenge and a key issue in drug discovery. Small molecule probes play an essential role in identifying targets of bioactive compounds. Photoaffinity labelling (PAL) has been developed as an emerging strategy owing to its capability of investigating the interaction between ligands and proteins. However, non-convalent interaction are too weak to precisely detect the target protein. PAL can cov...
Source: TrAC Trends in Analytical Chemistry - April 13, 2019 Category: Chemistry Source Type: research

NORMAN Digital Sample Freezing Platform: A European virtual platform to exchange liquid chromatography high resolution-mass spectrometry data and screen suspects in “digitally frozen” environmental samples
Publication date: Available online 12 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Nikiforos A. Alygizakis, Peter Oswald, Nikolaos S. Thomaidis, Emma L. Schymanski, Reza Aalizadeh, Tobias Schulze, Martina Oswaldova, Jaroslav SlobodnikAbstractA platform for archiving liquid chromatography high-resolution mass spectrometry (LC-HRMS) data was developed for the retrospective suspect screening of thousands of environmental pollutants with the ambition of becoming a European and possibly global standard. It was termed Digital Sample Freezing Platform (DSFP) and incorporates all the recent developments in the H...
Source: TrAC Trends in Analytical Chemistry - April 13, 2019 Category: Chemistry Source Type: research

Capillary gas chromatography-mass spectrometry: Current trends and perspectives
Publication date: Available online 12 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Beate Gruber, Frank David, Pat SandraAbstractSince the advent of gas chromatography - mass spectrometry (GC-MS), the evolution in high-performance GC-MS has boosted the quality and quantity of information. Continuing technical advances and topics of current focus are pushing GC-MS in areas such as metabolomics, biochemistry, medical analysis, and pharmacology, traditionally dominated by other separation techniques. Still, selection and optimization of sample preparation, analysis and data evaluation need to be carefully as...
Source: TrAC Trends in Analytical Chemistry - April 13, 2019 Category: Chemistry Source Type: research

Global Interlaboratory Assessments of Perfluoroalkyl Substances under the Stockholm Convention on Persistent Organic Pollutants
Publication date: Available online 10 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): H. Fiedler, I. van der Veen, J. de BoerSummaryThe Global Monitoring Plan (GMP) according to article 16 of the Stockholm Convention on Persistent Organic Pollutants (POPs) requires that POP laboratories must be capable – at any time – to analyse samples for POPs within a variation of ±25%. Based on this target error of 25%, a statistical model using z-scores was applied to assess the performance of analytical laboratories for POPs and a number of matrices. Since the second round of these ‘Bi-ennial ...
Source: TrAC Trends in Analytical Chemistry - April 11, 2019 Category: Chemistry Source Type: research

MALDI-MS for polymer characterization – recent developments and future prospects
Publication date: Available online 11 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Joanna Drzeżdżon, Dagmara Jacewicz, Alicja Sielicka, Lech ChmurzyńskiAbstractThe development of new polymerization methods and, consequently, the generation of new polymeric materials, is associated with the development of methods for testing the properties of these materials.The matrix assisted laser desorption and ionization - mass spectrometry method (MALDI-MS) is the technique used to study various polymers. The most important advantages of this method include the ability to determine the distribution of the molecul...
Source: TrAC Trends in Analytical Chemistry - April 11, 2019 Category: Chemistry Source Type: research

Photosynthesis-based hybrid nanostructures: electrochemical sensors and photovoltaic cells as case studies
Publication date: Available online 9 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Amina Antonacci, Viviana ScognamiglioAbstractThe recall of attention regarding the environment safeguard roused the scientific world, which currently addressed the issue by cutting-edge technologies merger. In particular, hybrid devices have been developed joining the natural elements originated from the photosynthetic process and different nanomaterials, with the purpose to monitor the release of toxic compounds as well as support alternative energy sources. In this review, we focus on recent studies attesting the maturity...
Source: TrAC Trends in Analytical Chemistry - April 10, 2019 Category: Chemistry Source Type: research

Current advances of carbon dots based biosensors for tumor marker detection, cancer cells analysis and bioimaging
Publication date: Available online 9 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Meghdad Pirsaheb, Somayeh Mohammadi, Abdollah SalimiAbstractThe effectiveness of cancer treatment and reducing cancer-related deaths strongly depends on the early diagnosis of cancer cells or related markers. Different nanomaterials have been applied for diagnosis, treatment and management of cancers. Between these, carbon dots (CDs) have unique properties. These include: low cost for synthesis/fabrication, high brightness, cell permeability and photostability, good intracellular solubility, high affinity and specificity to...
Source: TrAC Trends in Analytical Chemistry - April 10, 2019 Category: Chemistry Source Type: research

Core@Shell Nanomaterials Based Sensing Devices: A review
Publication date: Available online 9 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Pramod K. Kalambate, Dhanjai, Zeimei Huang, Yankai Li, Yue Shen, Meilan Xie, Yunhui Huang, Ashwini K. SrivastavaAbstractCore-shell nanomaterials (CSNs) have achieved huge popularity due to multifunctional properties achieved by manipulation of core or shell materials. This review highlights recent development in CSNs based sensing devices such as electrochemical sensors, optical sensors, wearable sensing devices, and gas adsorptive sensors, which find potential applications in numerous fields ranging from industrial, clinic...
Source: TrAC Trends in Analytical Chemistry - April 10, 2019 Category: Chemistry Source Type: research

Recent advances and future trends in LIBS applications to agricultural materials and their food derivatives: an overview of developments in the last decade (2010 – 2019). Part I. Soils and fertilizers
Publication date: Available online 9 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Gustavo Nicolodelli, Jader Cabral, Carlos Renato Menegati, Bruno Marangoni, Giorgio S. SenesiAbstractA review is provided on the last decade (2010 to 2019) applications of Laser-Induced Breakdown Spectroscopy (LIBS) technique to agricultural materials, including soils and fertilizers, also in combination with novel methodological and statistical approaches. In particular, the potential of double-pulse (DP)-LIBS, femtosecond (fs)-LIBS, micro-LIBS, nanoparticle-enhanced LIBS, and 3D elemental imaging and other recent advanced...
Source: TrAC Trends in Analytical Chemistry - April 10, 2019 Category: Chemistry Source Type: research

New Frontiers in Lipidomics Analyses using Structurally Selective Ion Mobility-Mass Spectrometry
Publication date: Available online 6 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Rachel A. Harris, Katrina L. Leaptrot, Jody C. May, John A. McLeanAbstractThe growth of lipidomics and the high isomeric complexity of the lipidome has revealed a need for analytical techniques capable of structurally characterizing lipids with a high degree of specificity. Lipids are morphologically diverse molecules that can exist as any one of a large number of isomeric species, and as such are often indistinguishable by mass spectrometry without a complementary separation method. Recent developments in the field of lipi...
Source: TrAC Trends in Analytical Chemistry - April 8, 2019 Category: Chemistry Source Type: research

Pressurized Hot Water Extraction Of Bioactives
Publication date: Available online 6 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Merichel Plaza, María Luisa MarinaAbstractIn the last years, the fact that water is a “green” solvents capable of tunable their properties by changing temperature has tended to increase publications using pressurized hot water extraction (PHWE) as a “green” extraction technique. PHWE has been established as a special extraction technique employed in obtaining bioactive compounds such as polyphenols, diterpenes and polysaccharides, among others from natural sources. Therefore, the main goal of ...
Source: TrAC Trends in Analytical Chemistry - April 8, 2019 Category: Chemistry Source Type: research