Imatinib treatment of paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (EsPhALL2010): a prospective, intergroup, open-label, single-arm clinical trial

Publication date: December 2018Source: The Lancet Haematology, Volume 5, Issue 12Author(s): Andrea Biondi, Virginie Gandemer, Paola De Lorenzo, Gunnar Cario, Myriam Campbell, Anders Castor, Rob Pieters, André Baruchel, Ajay Vora, Veronica Leoni, Jan Stary, Gabriele Escherich, Chi-Kong Li, Giovanni Cazzaniga, Hélène Cavé, Jutta Bradtke, Valentino Conter, Vaskar Saha, Martin Schrappe, Maria Grazia ValsecchiSummaryBackgroundThe EsPhALL2004 randomised trial showed a 10% advantage in disease-free survival for short, discontinuous use of imatinib after induction compared with no use of imatinib in patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia receiving Berlin-Frankfurt-Münster chemotherapy and haemopoietic stem-cell transplantation (HSCT). Other contemporary studies showed an advantage from continuous protracted exposure to imatinib, challenging the indications to transplant. The EsPhALL2010 study was designed to assess whether imatinib given from day 15 of induction and continuously throughout chemotherapy led to a different outcome to that obtained in EsPhALL2004, despite decreasing the number of patients having HSCT.MethodsThis prospective, intergroup, open-label, single-arm clinical trial (EsPhALL2010) was done at 11 study groups across Europe, Chile, and Hong Kong. Patients aged 1–17 years with the translocation t(9;22)(q34;q11) who were recruited into national front-line trials for acute lymphoblastic leukaemia were eligible for this tria...
Source: The Lancet Haematology - Category: Hematology Source Type: research