Three Years of Imatinib May Halve Death Rate in GIST Three Years of Imatinib May Halve Death Rate in GIST
Giving patients with high-risk gastrointestinal stromal tumors imatinib for 3 years rather than 1 year may reduce 10-year mortality by half, say German and Finnish investigators.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - June 8, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Onc Daily: 80K Missed Cancer Diagnoses, Generic Imatinib Onc Daily: 80K Missed Cancer Diagnoses, Generic Imatinib
These are the most important oncology stories you need to know about today.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 6, 2020 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Generic Imatinib Cuts Costs Without Affecting CML Outcomes Generic Imatinib Cuts Costs Without Affecting CML Outcomes
Clinicians and their chronic myeloid leukaemia patients looking to switch to generic imatinib will see no change in outcomes or safety, while markedly reducing healthcare costs, say UK researchers.Medscape News UK (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - May 5, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Zydus Cadila gets USFDA nod to market generic cancer drug
The company has received final approval from the US Food and Drug Administration (USFDA) to market its product which is a generic version of Gleevec tablets, Zydus Cadila said in a statement. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 9, 2020 Category: Pharmaceuticals Source Type: news

Neoadjuvant Imatinib for an Uncommon Breast Malignancy Neoadjuvant Imatinib for an Uncommon Breast Malignancy
This case highlights the differentiation of dermatofibrosarcoma protuberans from metaplastic breast carcinoma and other spindle cell lesions, as well as the use of imatinib as neoadjuvant treatment.Journal of Medical Case Reports (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - February 18, 2020 Category: Surgery Tags: Family Medicine/Primary Care Journal Article Source Type: news

Dasatinib Yields Superior Results Compared to Imatinib in Pediatric Patients with ALL
Combined with intensive chemotherapy, the next-generation inhibitor provided excellent results in pediatric patients with Philadelphia chromosome-positive ALL, leading to changes in how this population is treated. (Source: CancerNetwork)
Source: CancerNetwork - January 22, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Dasatinib Tops Imatinib for Ph + Acute Lymphoblastic Leukemia
Four - year cumulative risk of any relapse lower for dasatinib in the context of intensive chemotherapy (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - January 21, 2020 Category: Cancer & Oncology Tags: Oncology, Pathology, Pediatrics, Pharmacy, Journal, Source Type: news

Dasatinib Tops Imatinib for Ph & #43; Acute Lymphoblastic Leukemia
TUESDAY, Jan. 21, 2020 -- Dasatinib is associated with improved survival for pediatric patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL), according to a study published online Jan. 16 in JAMA Oncology. Shuhong Shen,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 21, 2020 Category: Pharmaceuticals Source Type: news

Prices Drop At Last for Transformative Cancer Drug Prices Drop At Last for Transformative Cancer Drug
When its generic version of imatinib first hit the marketplace, the price tag was nearly indistinguishable from the branded product, but the times'they are a-changing. 'Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - December 19, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Antibody eradicates leukemia stem cells
The introduction of the drug imatinib in 2001 revolutionized the treatment of a type of cancer called chronic myelogenous leukemia. In more than 80% of people with CML who received the drug, the disease went into complete remission.However, in most people with chronic myelogenous leukemia, cancerous stem cells remain in the body for years after their cancer has gone into remission. If treatment with imatinib or another similar medication is stopped — and in some cases, even while treatment continues — the leukemia stem cells can cause cancer to recur.Now, in experiments in mice as well as isolated human cancer ...
Source: UCLA Newsroom: Health Sciences - October 15, 2019 Category: Universities & Medical Training Source Type: news

imatinib (Gleevec)
Title: imatinib (Gleevec)Category: MedicationsCreated: 3/2/2005 12:00:00 AMLast Editorial Review: 8/15/2019 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - August 15, 2019 Category: Cancer & Oncology Source Type: news

Drug monitoring optimises imatinib dosing cost effectively
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - May 31, 2019 Category: Drugs & Pharmacology Source Type: news

Wockhardt gets USFDA nod for generic cancer drug
Wockhardt's Imatinib Mesylate tablets are a generic version of Gleevec, marketed in USA and other countries by Novartis. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - January 21, 2019 Category: Pharmaceuticals Source Type: news

Company-Led Drug Alert: Imatinib 400mg Capsules PL 36390/0180
The Medicines and Healthcare products Regulatory Agency (MHRA) has issued a company-led recall for Imatinib 400mg Capsules. Cipla (EU) Limited has informed the MHRA that there is an error on the Pat (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - September 20, 2018 Category: Drugs & Pharmacology Source Type: news

The Curious Case Of Gleevec Pricing
As a branded drug, Gleevec's price increases were the target of criticism by oncologists, payers, and patients. Yet, its price was more reflective of value than many other cancer drugs. What is problematic is the fact that generic imatinib's list price has remained stubbornly high. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - September 12, 2018 Category: Pharmaceuticals Authors: Joshua Cohen, Contributor Source Type: news

OHSU's Druker wins prestigious award for developing Gleevec
The 2018 Tang Prize in Biopharmaceutical Science recognizes Druker for his pioneering role in precision medicine. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - June 19, 2018 Category: American Health Authors: Elizabeth Hayes Source Type: news

OHSU's Druker wins prestigious award for developing Gleevec
The 2018 Tang Prize in Biopharmaceutical Science recognizes Druker for his pioneering role in precision medicine. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - June 19, 2018 Category: Biotechnology Authors: Elizabeth Hayes Source Type: news

Imatinib-induced Fulminant Liver Failure in CML Imatinib-induced Fulminant Liver Failure in CML
Acute liver failure can be a fatal adverse effect of chronic myeloid leukemia treatment with imatinib. Is liver transplant a viable option for these patients?Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 23, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Cost Savings Limited With Generic Imatinib
WEDNESDAY, May 9, 2018 -- Prices of imatinib (Gleevec) remained high even after a generic version was introduced, according to a study published in the May issue of Health Affairs. Ashley L. Cole, from the University of North Carolina at Chapel... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 9, 2018 Category: Pharmaceuticals Source Type: news

Generic Drugs Don't Always Push Prices Down
MONDAY, May 7, 2018 -- Generic drugs tend to trigger big drops in the cost of their expensive, brand-name counterparts, but that has not been the case with the cancer drug commonly known as Gleevec (imatinib). There's been only a small drop in the... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 7, 2018 Category: General Medicine Source Type: news

Generic options provide limited savings for expensive drugs
(Vanderbilt University Medical Center) Generic drug options did not reduce prices paid for the cancer therapy imatinib (Gleevec), according to a Health Affairs study released today in its May issue. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 7, 2018 Category: Cancer & Oncology Source Type: news

Mylan launches generic version of Gleevec tablets in US
Mylan has launched the generic version of Novartis's Gleevec tablets, Imatinib Mesylate, in 100mg and 400mg versions in the US.   (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - October 2, 2017 Category: Pharmaceuticals Source Type: news

Imatinib a Double-Edged Sword for Pregnant CML Patients Imatinib a Double-Edged Sword for Pregnant CML Patients
On the one hand, imatinib keeps the CML in check; on the other hand, it carries a risk for fetal congenital malformation if taken during pregnancy.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - September 19, 2017 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Imatinib shows increased survival in ICR ’s Phase III oncology trial
A Phase III clinical trial of imatinib (Glivec) conducted by UK researchers from the Institute of Cancer Research (ICR) and the Royal Marsden NHS Foundation Trust demonstrated increased survival in patients with advanced gastrointestinal stromal tumo … (Source: Drug Development Technology)
Source: Drug Development Technology - August 21, 2017 Category: Pharmaceuticals Source Type: news

CML Patients Approach Normal Life Expectancy With Imatinib Treatment
Treatment with imatinib results in good overall survival in patients with chronic myeloid leukemia, approaching a normal life expectancy, according to the CML-IV study. (Source: CancerNetwork)
Source: CancerNetwork - July 21, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Chronic Myeloid Leukemia Hematologic Malignancies & Lymphoma News Source Type: news

Novartis unit Alcon posts modest Q2 gain
(Reuters) — Long-suffering Novartis (NYSE:NVS) unit Alcon‘s sales growth accelerated in the second quarter, boosting options for the business including a possible disposal, CEO Joe Jimenez said today. The eye care subsidiary’s sales rose 1% to $1.5 billion, including intraocular lens revenues, which grew for the first time in the second quarter since 2014. Spending continued to promote products with eye surgeons, resulting in a $19 million operating loss. Novartis has been reviewing Alcon for a possible disposal, with an update slated for this year. All options are under consideration, Jimenez reiter...
Source: Mass Device - July 18, 2017 Category: Medical Devices Authors: Brad Perriello Tags: MassDevice Earnings Roundup Mergers & Acquisitions Optical/Ophthalmic Wall Street Beat Alcon Novartis Source Type: news

Survival in Imatinib-Treated CML Independent of Response Time Survival in Imatinib-Treated CML Independent of Response Time
The 10-year survival analysis shows no significant difference in outcomes based on imatinib regimen, including higher dose that has previously been linked to a faster response.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 5, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Dasatinib in Children: An Effective Alternative to Imatinib Dasatinib in Children: An Effective Alternative to Imatinib
In children and adolescents with chronic-phase chronic myeloid leukemia, dasatinib shows response rates and safety similar to those seen in adults.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 29, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Cancer Drug Imatinib May Slow New-Onset Type 1 Diabetes Cancer Drug Imatinib May Slow New-Onset Type 1 Diabetes
"This could one day be a treatment for type 1 diabetes, but this remains very early days," says the researcher.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 26, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Frontline Bostunib vs Imatinib in Chronic Myeloid Leukemia
This video highlights results of the BFORE trial, which tested bosutinib vs imatinib in newly diagnosed chronic myeloid leukemia patients. (Source: CancerNetwork)
Source: CancerNetwork - June 6, 2017 Category: Cancer & Oncology Authors: Jorge E. Cortes, MD Tags: Conferences/ASCO Hematology Chronic Myeloid Leukemia News Videos Hematologic Malignancies Source Type: news

Dasatinib excels in worldwide phase II trial against pediatric CML
(University of Colorado Anschutz Medical Campus) Worldwide phase II clinical trial results presented ASCO 2017 show the promise of the second-generation drug dasatinib against pediatric CML. Of 113 pediatric patients studied, 75 percent of patients who had previously failed or did not tolerate imatinib saw progression-free survival 48 months after starting treatment with dasatinib. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 5, 2017 Category: International Medicine & Public Health Source Type: news

KIT Inhibition by Imatinib Helps Severe Refractory Asthma
Improvement in airway hyperresponsiveness seen with imatinib versus placebo (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - May 22, 2017 Category: Respiratory Medicine Tags: Family Medicine, Internal Medicine, Allergy, Emergency Medicine, Nursing, Pediatrics, Pharmacy, Pulmonology, Journal, Source Type: news

Could Cancer Drug Gleevec Help With Severe Asthma?
Title: Could Cancer Drug Gleevec Help With Severe Asthma?Category: Health NewsCreated: 5/19/2017 12:00:00 AMLast Editorial Review: 5/22/2017 12:00:00 AM (Source: MedicineNet Asthma General)
Source: MedicineNet Asthma General - May 22, 2017 Category: Respiratory Medicine Source Type: news

Could Cancer Drug Gleevec Help With Severe Asthma?
A leukemia drug might also effectively treat severe asthma, a small-scale clinical trial suggests. (Source: Health News - UPI.com)
Source: Health News - UPI.com - May 19, 2017 Category: Consumer Health News Source Type: news

Cancer drug Gleevec may help with severe asthma
A leukemia drug might also effectively treat severe asthma, a small-scale clinical trial suggests. (Source: Health News - UPI.com)
Source: Health News - UPI.com - May 19, 2017 Category: Consumer Health News Source Type: news

Could Cancer Drug Gleevec Help With Severe Asthma?
Small study suggests a new approach might one day help those with uncontrolled lung disease (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - May 19, 2017 Category: Respiratory Medicine Tags: Nursing, Oncology, Pharmacy, Pulmonology, Asthma, Research, News, Source Type: news

Could Cancer Drug Gleevec Help with Severe Asthma?
Small study suggests a new approach might one day help those with uncontrolled lung disease Source: HealthDay Related MedlinePlus Pages: Asthma, Leukemia, Medicines (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - May 19, 2017 Category: Consumer Health News Source Type: news

Could Cancer Drug Gleevec Help With Severe Asthma?
FRIDAY, May 19, 2017 -- A leukemia drug might also effectively treat severe asthma, a small-scale clinical trial suggests. Gleevec (imatinib) reduced the " twitchiness " of airways, making them less likely to reflexively constrict when exposed to an... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 19, 2017 Category: General Medicine Source Type: news

Proof-of principle study finds imatinib improves symptoms for patients with severe asthma
In a new, proof-of-principle study researchers have found that targeting the mast cells with imatinib, a drug used to effectively treat certain forms of cancer, improved airway hyperresponsiveness, a measure of the sensitivity of the airway, and decreased the number of mast cells present in the airway. Treatment also produced a small improvement in airway function. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 17, 2017 Category: Science Source Type: news

Proof-of Principle Study Finds Imatinib Improves Symptoms for Patients with Severe Asthma
In a new, proof-of-principle study, researchers found that targeting the mast cells with imatinib, a drug used to effectively treat certain forms of cancer, improved airway hyper responsiveness, and decreased the number of mast cells present. (Source: BWH News)
Source: BWH News - May 17, 2017 Category: Hospital Management Source Type: news

Novartis misses on rev, tops sales estimates in Q1
Shares in Novartis (NYSE:NVS) rose today after the pharmaceutical company met expectations on Wall Street with its 1st quarter earnings, but missed on sales largely thanks to growing pressure from generics to the company’s top-selling chemotherapy, Gleevec. The company posted profits of $1.92 billion, or 22¢ per share, on sales of $11.53 billion for the 3 months ended March 31, for bottom-line loss of -22% on sales loss of -1% compared with the same period last year. Get the full story at our sister site, Drug Delivery Business News. The post Novartis misses on rev, tops sales estimates in Q1...
Source: Mass Device - April 25, 2017 Category: Medical Equipment Authors: Sarah Faulkner Tags: MassDevice Earnings Roundup Optical/Ophthalmic Pharmaceuticals Wall Street Beat Novartis Source Type: news

KIT Mutations Linked to Imatinib Response in GIST KIT Mutations Linked to Imatinib Response in GIST
Different KIT mutations have various associations with the response of gastrointestinal stromal tumors (GISTs) to adjuvant imatinib, according to results from a Scandinavian Sarcoma Group multicenter trial.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - April 3, 2017 Category: Surgery Tags: Hematology-Oncology News Source Type: news

TKIs Associated With Subclinical Pulmonary Hypertension in CML Patients
Treatment of CML with tyrosine kinase inhibitors including imatinib, nilotinib, and dasatinib can be associated with subclinical pulmonary hypertension. (Source: CancerNetwork)
Source: CancerNetwork - March 29, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Chronic Myeloid Leukemia Hematologic Malignancies & Lymphoma News Source Type: news

Gleevec - A Game Changer?
(MedPage Today) -- The drug has improved survival for the majority of CML patients (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - March 22, 2017 Category: American Health Source Type: news

New England Journal of Medicine publishes long-term results of Gleevec ®
In 2001 the U.S. Food and Drug Administration granted priority review for imatinib mesylate, sold under the name Gleevec®*, as an oral therapy for patients with chronic myeloid leukemia, or CML. The New England Journal of Medicine has published results from a nearly 11-year follow-up study, that showed an estimated overall survival rate of 83.3 percent. (Source: World Pharma News)
Source: World Pharma News - March 10, 2017 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news