The undocumented struggle with emergency-only dialysis
Publication date: September 2018Source: The Lancet Haematology, Volume 5, Issue 9Author(s): The Lancet Haematology (Source: The Lancet Haematology)
Source: The Lancet Haematology - August 30, 2018 Category: Hematology Source Type: research

Lenalidomide and R-CHOP in follicular lymphoma: where do we go from here?
Publication date: September 2018Source: The Lancet Haematology, Volume 5, Issue 9Author(s): Leo I Gordon (Source: The Lancet Haematology)
Source: The Lancet Haematology - August 30, 2018 Category: Hematology Source Type: research

Predictive value of faecal adenoviral load for viraemia
Publication date: September 2018Source: The Lancet Haematology, Volume 5, Issue 9Author(s): Genovefa Papanicolaou (Source: The Lancet Haematology)
Source: The Lancet Haematology - August 30, 2018 Category: Hematology Source Type: research

Lenalidomide in combination with R-CHOP (R2-CHOP) as first-line treatment of patients with high tumour burden follicular lymphoma: a single-arm, open-label, phase 2 study
Publication date: September 2018Source: The Lancet Haematology, Volume 5, Issue 9Author(s): Hervé Tilly, Franck Morschhauser, Olivier Casasnovas, Thierry Jo Molina, Pierre Feugier, Steven Le Gouill, Corinne Haioun, Olivier Tournilhac, Reda Bouabdallah, Jean Gabarre, Thierry Lamy, José Cabeçadas, Stéphanie Becker, Fabrice Jardin, Nicolas Mounier, Gilles Salles, Lymphoma Study AssociationSummaryBackgroundImmunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is a standard front-line treatment for follicular lymphoma. The combination of lenalidomide a...
Source: The Lancet Haematology - August 30, 2018 Category: Hematology Source Type: research

Should an HLA-matched donor still be considered the perfect donor?
Publication date: September 2018Source: The Lancet Haematology, Volume 5, Issue 9Author(s): Richard J Jones, Mary M Horowitz (Source: The Lancet Haematology)
Source: The Lancet Haematology - August 30, 2018 Category: Hematology Source Type: research

Artificial intelligence for cancer-associated thrombosis risk assessment
Publication date: September 2018Source: The Lancet Haematology, Volume 5, Issue 9Author(s): Patrizia Ferroni, Mario Roselli, Fabio M Zanzotto, Fiorella Guadagni (Source: The Lancet Haematology)
Source: The Lancet Haematology - August 30, 2018 Category: Hematology Source Type: research

Artificial intelligence for cancer-associated thrombosis risk assessment – Author's reply
Publication date: September 2018Source: The Lancet Haematology, Volume 5, Issue 9Author(s): Alok A Khorana (Source: The Lancet Haematology)
Source: The Lancet Haematology - August 30, 2018 Category: Hematology Source Type: research

Molecular monitoring of adenovirus reactivation in faeces after haematopoietic stem-cell transplantation to predict systemic infection: a retrospective cohort study
Publication date: September 2018Source: The Lancet Haematology, Volume 5, Issue 9Author(s): Ryan Malcolm Hum, David Deambrosis, Su Han Lum, Emma Davies, Denise Bonney, Malcolm Guiver, Andrew Turner, Robert Francis Wynn, Prashant HiwarkarSummaryBackgroundFaecal shedding of adenovirus following allogeneic haematopoietic stem-cell transplantation (HSCT) is an early sign of loss of immune control over adenovirus, but there is no consensus on the role of monitoring of faecal adenoviral load by serial testing. We investigated whether serial faecal PCR monitoring could predict the risk of adenoviraemia and survival outcomes after...
Source: The Lancet Haematology - August 30, 2018 Category: Hematology Source Type: research

Advancing haematological research and clinical practice: a call for papers for ASH 2018
Publication date: Available online 16 August 2018Source: The Lancet HaematologyAuthor(s): Jiaying Tan, Vania Wisdom, David Collingridge (Source: The Lancet Haematology)
Source: The Lancet Haematology - August 17, 2018 Category: Hematology Source Type: research

Blurring lines between treatment intensity and patient fitness in elderly people with AML
Publication date: Available online 13 August 2018Source: The Lancet HaematologyAuthor(s): Norbert Vey (Source: The Lancet Haematology)
Source: The Lancet Haematology - August 14, 2018 Category: Hematology Source Type: research

Cladribine and low-dose cytarabine alternating with decitabine as front-line therapy for elderly patients with acute myeloid leukaemia: a phase 2 single-arm trial
Publication date: Available online 13 August 2018Source: The Lancet HaematologyAuthor(s): Tapan M Kadia, Jorge Cortes, Farhad Ravandi, Elias Jabbour, Marina Konopleva, Christopher B Benton, Jan Burger, Koji Sasaki, Gautam Borthakur, Courtney D DiNardo, Naveen Pemmaraju, Naval Daver, Alessandra Ferrajoli, Xuemei Wang, Keyur Patel, Jeffrey L Jorgensen, Sa Wang, Susan O'Brien, Sherry Pierce, Carla TuttleSummaryBackgroundFront-line therapy for elderly or unfit patients with acute myeloid leukaemia (AML) remains unsatisfactory with poor outcomes and excessive toxicity. We studied a new low-intensity regimen of cladribine combin...
Source: The Lancet Haematology - August 14, 2018 Category: Hematology Source Type: research

The FDA's definitions, designations, and drug approvals: too daring?
Publication date: August 2018Source: The Lancet Haematology, Volume 5, Issue 8Author(s): The Lancet Haematology (Source: The Lancet Haematology)
Source: The Lancet Haematology - August 1, 2018 Category: Hematology Source Type: research

23rd European Hematology Association Congress
Publication date: August 2018Source: The Lancet Haematology, Volume 5, Issue 8Author(s): Lan-Lan Smith (Source: The Lancet Haematology)
Source: The Lancet Haematology - August 1, 2018 Category: Hematology Source Type: research

Correction to Lancet Haematol 2018; 5: e289–98
Publication date: August 2018Source: The Lancet Haematology, Volume 5, Issue 8Author(s): (Source: The Lancet Haematology)
Source: The Lancet Haematology - August 1, 2018 Category: Hematology Source Type: research

Correction to Lancet Haematol 2018; 5: e273–74
Publication date: August 2018Source: The Lancet Haematology, Volume 5, Issue 8Author(s): (Source: The Lancet Haematology)
Source: The Lancet Haematology - August 1, 2018 Category: Hematology Source Type: research

Risk of second primary cancer following myeloid neoplasia and risk of myeloid neoplasia as second primary cancer: a nationwide, observational follow up study in Sweden
Publication date: August 2018Source: The Lancet Haematology, Volume 5, Issue 8Author(s): Subhayan Chattopadhyay, Guoqiao Zheng, Amit Sud, Hongyao Yu, Kristina Sundquist, Jan Sundquist, Asta Försti, Akseli Hemminki, Richard Houlston, Kari HemminkiSummaryBackgroundAlthough advances in the treatment of myeloid neoplasms have led to improved patient survival, this improvement has been accompanied by an increased risk of second primary cancer (ie, the risk of another cancer after myeloid neoplasia). We aimed to assess bi-directional associations between myeloid cancers and other cancers—ie, development of second prim...
Source: The Lancet Haematology - August 1, 2018 Category: Hematology Source Type: research

Secondary primary cancers before and after myeloid neoplasia: a two-way street
Publication date: August 2018Source: The Lancet Haematology, Volume 5, Issue 8Author(s): Guillermo Garcia-Manero (Source: The Lancet Haematology)
Source: The Lancet Haematology - August 1, 2018 Category: Hematology Source Type: research

Assessment of ASC specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: an observational cohort study
Publication date: Available online 30 July 2018Source: The Lancet HaematologyAuthor(s): Ashley A Basiorka, Kathy L McGraw, Farnoosh Abbas-Aghababazadeh, Amy F McLemore, Nicole D Vincelette, Grace A Ward, Erika A Eksioglu, David A Sallman, Najla Al Ali, Eric Padron, Javier Pinilla-Ibarz, Rami Komrokji, Erico Masala, Valeria Santini, Olivier Kosmider, Michaela Fontenay, Pierre Fenaux, Lubomir Sokol, Sheng Wei, Brooke FridleySummaryBackgroundNLRP3 inflammasome-directed pyroptotic cell death drives ineffective haemopoiesis in myelodysplastic syndromes. During inflammasome assembly, the apoptosis-associated speck-like protein c...
Source: The Lancet Haematology - July 31, 2018 Category: Hematology Source Type: research

ASC specks: a biomarker for myelodysplastic syndromes?
Publication date: Available online 30 July 2018Source: The Lancet HaematologyAuthor(s): Dominik Wolf, Eicke Latz (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 31, 2018 Category: Hematology Source Type: research

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study
Publication date: Available online 20 July 2018Source: The Lancet HaematologyAuthor(s): Carolyne M Ndila, Sophie Uyoga, Alexander W Macharia, Gideon Nyutu, Norbert Peshu, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Benjamin Tsofa, Nuno Sepúlveda, Taane G Clark, Gavin Band, Geraldine Clarke, Kate Rowlands, Christina Hubbart, Anna Jeffreys, Silvia Kariuki, Kevin Marsh, Margaret MackinnonSummaryBackgroundHuman genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells&...
Source: The Lancet Haematology - July 20, 2018 Category: Hematology Source Type: research

Genes expressed in red cells could shape a malaria attack
Publication date: Available online 20 July 2018Source: The Lancet HaematologyAuthor(s): Lucio Luzzatto (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 20, 2018 Category: Hematology Source Type: research

Correction to Lancet Haematol 2017; 4: e431–42
Publication date: Available online 18 July 2018Source: The Lancet HaematologyAuthor(s): (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 18, 2018 Category: Hematology Source Type: research

Leukaemia risk associated with low-dose radiation
Publication date: Available online 17 July 2018Source: The Lancet HaematologyAuthor(s): Christopher S Hourigan, Bipin N Savani (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 18, 2018 Category: Hematology Source Type: research

Leukaemia and myeloid malignancy among people exposed to low doses (<100 mSv) of ionising radiation during childhood: a pooled analysis of nine historical cohort studies
Publication date: Available online 17 July 2018Source: The Lancet HaematologyAuthor(s): Mark P Little, Richard Wakeford, David Borrego, Benjamin French, Lydia B Zablotska, M Jacob Adams, Rodrigue Allodji, Florent de Vathaire, Choonsik Lee, Alina V Brenner, Jeremy S Miller, David Campbell, Mark S Pearce, Michele M Doody, Erik Holmberg, Marie Lundell, Siegal Sadetzki, Martha S Linet, Amy Berrington de GonzálezSummaryBackgroundSubstantial evidence links exposure to moderate or high doses of ionising radiation, particularly in childhood, with increased risk of leukaemia. The association of leukaemia with exposure to low-dose (
Source: The Lancet Haematology - July 18, 2018 Category: Hematology Source Type: research

Bitter progress in the treatment of haemophilia A in low-income countries
Publication date: June 2018Source: The Lancet Haematology, Volume 5, Issue 6Author(s): Jean-Claude Faber, Thierry Burnouf (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Gemcitabine-oxaliplatin plus rituximab (R-GemOx) as first-line treatment in elderly patients with diffuse large B-cell lymphoma: a single-arm, open-label, phase 2 trial
This study is registered with ClinicalTrials.gov, number NCT01670370.FindingsBetween Aug 22, 2012, and Dec 31, 2015, 60 patients were enrolled and included in the study. The median age of the patients was 75 years (IQR 70–80) and 27 (45%) patients had a poor performance status with an ECOG score of 2 or greater. 45 (75%) patients achieved an overall response at the end of the treatment, with 28 (47%) achieving a complete response. Common grade 3–4 adverse events were haematological toxicities (thrombocytopenia in five [8%] patients, anaemia in four [7%], and neutropenia in nine [15%]) and gastrointestinal compl...
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Tailored frequency-escalated primary prophylaxis for severe haemophilia A: results of the 16-year Canadian Hemophilia Prophylaxis Study longitudinal cohort
This study was initially funded by grants from the Medical Research Council of Canada/Pharmaceutical Manufacturers Association of Canada Partnership Fund and the Bayer/Canadian Blood Services/Hema-Quebec Partnership Fund. Subsequent renewals were funded by Bayer. (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Automated typing of red blood cell and platelet antigens: a whole-genome sequencing study
Publication date: June 2018Source: The Lancet Haematology, Volume 5, Issue 6Author(s): William J Lane, Connie M Westhoff, Nicholas S Gleadall, Maria Aguad, Robin Smeland-Wagman, Sunitha Vege, Daimon P Simmons, Helen H Mah, Matthew S Lebo, Klaudia Walter, Nicole Soranzo, Emanuele Di Angelantonio, John Danesh, David J Roberts, Nick A Watkins, Willem H Ouwehand, Adam S Butterworth, Richard M Kaufman, Heidi L Rehm, Leslie E SilbersteinSummaryBackgroundThere are more than 300 known red blood cell (RBC) antigens and 33 platelet antigens that differ between individuals. Sensitisation to antigens is a serious complication that can...
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Correction to Lancet Haematol 2018; 5: e170–80
Publication date: June 2018Source: The Lancet Haematology, Volume 5, Issue 6Author(s): (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

The effect of chromatin states on cancer: big data lead the way
Publication date: June 2018Source: The Lancet Haematology, Volume 5, Issue 6Author(s): Xufeng Chen, Iannis Aifantis (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Seeking solutions to old problems in elderly patients with lymphoma
Publication date: June 2018Source: The Lancet Haematology, Volume 5, Issue 6Author(s): Andrés José María Ferreri (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Whole-genome sequencing algorithm for blood-group typing
Publication date: June 2018Source: The Lancet Haematology, Volume 5, Issue 6Author(s): Robert Flower, Eileen Roulis, Catherine Hyland (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Putting an end to the sequelae of contaminated blood transfusions
Publication date: June 2018Source: The Lancet Haematology, Volume 5, Issue 6Author(s): The Lancet Haematology (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Changing views on adverse event reporting
Publication date: Available online 12 June 2018Source: The Lancet HaematologyAuthor(s): Beatriz Flores, Sigrid Klaar, Daniel J O'Connor (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

The cost of cure
Publication date: Available online 12 June 2018Source: The Lancet HaematologyAuthor(s): Kjeld Schmiegelow, Thomas Leth Frandsen (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

The need to assess financial adverse events
Publication date: Available online 12 June 2018Source: The Lancet HaematologyAuthor(s): Loretta J Nastoupil, Vinay Prasad, Christopher R Flowers (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Real-world evidence in safety assessment of new treatments
Publication date: Available online 12 June 2018Source: The Lancet HaematologyAuthor(s): Karin E Smedby, Sandra Eloranta (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Correction to Lancet Haematol 2018; published online June 6. http://dx.doi.org/10.1016/S2352-3026(18)30063-2
Publication date: Available online 18 June 2018Source: The Lancet HaematologyAuthor(s): (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Correction to Lancet Haematol 2018; published online June 6. http://dx.doi.org/10.1016/S2352-3026(18)30067-X
Publication date: Available online 18 June 2018Source: The Lancet HaematologyAuthor(s): (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Beyond maximum grade: modernising the assessment and reporting of adverse events in haematological malignancies
Publication date: Available online 18 June 2018Source: The Lancet HaematologyAuthor(s): Gita Thanarajasingam, Lori M Minasian, Frederic Baron, Franco Cavalli, R Angelo De Claro, Amylou C Dueck, Tarec C El-Galaly, Neil Everest, Jan Geissler, Christian Gisselbrecht, John Gribben, Mary Horowitz, S Percy Ivy, Caron A Jacobson, Armand Keating, Paul G Kluetz, Aviva Krauss, Yok Lam Kwong, Richard F Little, Francois-Xavier MahonSummaryTremendous progress in treatment and outcomes has been achieved across the whole range of haematological malignancies in the past two decades. Although cure rates for aggressive malignancies have inc...
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

A new option for treating CKD-associated anaemia in children
Publication date: July 2018Source: The Lancet Haematology, Volume 5, Issue 7Author(s): The Lancet Haematology (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Treatment and outcome patterns in European patients with Waldenström's macroglobulinaemia: a large, observational, retrospective chart review
Publication date: July 2018Source: The Lancet Haematology, Volume 5, Issue 7Author(s): Christian Buske, Shalal Sadullah, Efstathios Kastritis, Alessandra Tedeschi, Ramón García-Sanz, Lukasz Bolkun, Xavier Leleu, Wolfgang Willenbacher, Roman Hájek, Monique C Minnema, Mei Cheng, Elizabeth Bilotti, Thorsten Graef, Meletios A Dimopoulos, European Consortium for Waldenström's MacroglobulinemiaSummaryBackgroundTreatment options for Waldenström's macroglobulinaemia are heterogeneous, and no well established treatment standards exist. Although guidelines from the Eighth International Workshop on Wald...
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Intravenous iron sucrose versus oral iron administration for the postoperative treatment of post-bariatric abdominoplasty anaemia: an open-label, randomised, superiority trial in Brazil
Publication date: July 2018Source: The Lancet Haematology, Volume 5, Issue 7Author(s): Juan Carlos Montano-Pedroso, Elvio Bueno Garcia, Mariana Alcântara Rodrigues de Moraes, Daniela Francescato Veiga, Lydia Masako FerreiraSummaryBackgroundAnaemia and iron deficiency are common after post-bariatric abdominoplasty, which can involve removal of large areas of skin with associated blood loss. Because the oral absorbability of iron is reduced after bariatric surgery (through reduced intake, reduction of gastric acid secretion for conjugation of iron, and separation of the iron-absorptive areas of the duodenum and jejunum...
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

A clinical prediction model for cancer-associated venous thromboembolism: a development and validation study in two independent prospective cohorts
Publication date: July 2018Source: The Lancet Haematology, Volume 5, Issue 7Author(s): Ingrid Pabinger, Nick van Es, Georg Heinze, Florian Posch, Julia Riedl, Eva-Maria Reitter, Marcello Di Nisio, Gabriela Cesarman-Maus, Noémie Kraaijpoel, Christoph Carl Zielinski, Harry Roger Büller, Cihan AySummaryBackgroundVenous thromboembolism is a common complication of cancer, but the risk of developing venous thromboembolism varies greatly among individuals and depends on numerous factors, including type of cancer. We aimed to develop and externally validate a clinical prediction model for cancer-associated venous throm...
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Venous thromboembolism after induced abortion: the shorter the pregnancy, the lower the risk?
Publication date: July 2018Source: The Lancet Haematology, Volume 5, Issue 7Author(s): Saskia Middeldorp, Willem M Ankum (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Simplicity versus complexity: an existential dilemma as risk tools evolve
Publication date: July 2018Source: The Lancet Haematology, Volume 5, Issue 7Author(s): Alok A Khorana (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

The real world of Waldenström's macroglobulinaemia
Publication date: July 2018Source: The Lancet Haematology, Volume 5, Issue 7Author(s): Steven P Treon, Jorge J Castillo (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Intravenous iron in post-bariatric abdominoplasty anaemia: a pragmatic approach
Publication date: July 2018Source: The Lancet Haematology, Volume 5, Issue 7Author(s): Alhossain A Khalafallah (Source: The Lancet Haematology)
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Venous thromboembolism after induced abortion: a population-based, propensity-score-matched cohort study in Canada
Publication date: July 2018Source: The Lancet Haematology, Volume 5, Issue 7Author(s): Ning Liu, Simone N Vigod, M Michèle Farrugia, Marcelo L Urquia, Joel G RaySummaryBackgroundA woman's risk of venous thromboembolism during pregnancy is estimated to be two-to-six times higher than her risk when she is not pregnant. Such risk estimates are largely based on pregnancies that result in delivery of a newborn baby; no estimates exist for the risk of venous thromboembolism after induced abortion, another common pregnancy outcome. To fill this knowledge gap, we aimed to assess the risk of venous thromboembolism in women w...
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research

Rituximab and the risk of transformation of follicular lymphoma: a retrospective pooled analysis
Publication date: Available online 4 July 2018Source: The Lancet HaematologyAuthor(s): Massimo Federico, María Dolores Caballero Barrigón, Luigi Marcheselli, Vittoria Tarantino, Martina Manni, Clementine Sarkozy, Sara Alonso-Álvarez, Marielle Wondergem, Guillaume Cartron, Armando Lopez-Guillermo, Djamila Issa, Franck Morschhauser, Miguel Alcoceba, Eva Kimby, Chiara Rusconi, Martine Chamuleau, Harald Holte, Sandra Lockmer, Silvia Montoto, Maria Gomes da SilvaSummaryBackgroundHistological transformation of follicular lymphoma to aggressive lymphoma is a serious event with a substantial effect on patient ...
Source: The Lancet Haematology - July 10, 2018 Category: Hematology Source Type: research