Transient Elastography Anticipates the Diagnosis of VOD/SOS after Adult Allogeneic Stem Cell Transplant: Results from a Prospective Study

We report the results of a prospective single center study evaluating the role of LSM assessed by Transient Elastography (TE), in adult patients undergoing allogeneic HSCT for haematological malignancies since April 2016 at the Institute of Hematology "L. and A. Seràgnoli", Sant'Orsola-Malpighi University Hospital, Bologna, Italy. The exclusion criteria were patients with Body Mass Index (BMI) over 40 kg/m2, ascites and diagnosis of advanced chronic liver disease (ACLD) at pre-HSCT assessment. LSM were assessed bedside of patients by TE, using the FibroScan® apparatus with "M" probe (Echosens, Paris, France), after overnight fasting and after a complete abdominal US exam, before the start of conditioning regimen and then at 3 time points after transplant (on days +9/10, +15/17 and +22/24).Results: Over the study period, among of 89 patients referred to our centre 78 patients fulfilled the inclusion criteria. Median age was 54 years (40-60). The most frequent indication was Acute Myeloid Leukemia (44.9%). 66.7% of patients received a myeloablative conditioning while 33.3% received a RIC regimen. 15.4% were transplanted from HLA identical sibling donor, 74.4% from unrelated donor, 3.8% from Haplo and 6.4% from Cord Blood. The baseline median LSM was 4.2 kPa (3.8-5.3).During the study, 4 out 78 patients (5.1%) met clinical diagnostic criteria of VOD/SOS. The median day of VOD/SOS diagnosis was +17 (+1 - +29). Most of the VOD/SOS were Severe/Very severe (3/4), one of t...
Source: Blood - Category: Hematology Authors: Tags: 721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities: Poster I Source Type: research