3 Evolutionary Scientists Win Nobel Chemistry Prize

(STOCKHOLM) — Three researchers who “harnessed the power of evolution” to produce enzymes and antibodies that have led to a new best-selling drug and biofuels won the Nobel Prize in chemistry on Wednesday. Frances Arnold of the California Institute of Technology was awarded half of the 9-million-kronor ($1.01 million) prize, while the other half will be shared by George Smith of the University of Missouri and Gregory Winter of the MRC molecular biology lab in Cambridge, England. The Royal Swedish Academy of Sciences, which chose the winners, said Arnold, 62, conducted the first directed evolution of enzymes, whose uses include “more environmentally friendly manufacturing of chemical substances such as pharmaceuticals and the production of renewable fuels.” BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the #NobelPrize in Chemistry 2018 with one half to Frances H. Arnold and the other half jointly to George P. Smith and Sir Gregory P. Winter. pic.twitter.com/lLGivVLttB — The Nobel Prize (@NobelPrize) October 3, 2018 Smith, 77, developed a method to evolve new proteins and Winter used the method to evolve antibodies, which are disease-fighting proteins in the blood. The first pharmaceutical based on Winter’s work was approved for use in 2002 and is employed to treat rheumatoid arthritis, psoriasis and inflammatory bowel diseases, the academy said. The chemical name of the drug is adalimumab, which has se...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized nobel prize onetime Source Type: news

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We report the case of a 68-year-old man with Crohn's disease, who developed  disseminated tuberculosis due to anti-TNF-α immunosuppressive therapy. The diagnosis was based on the histopathological findings and molecular biology assays.We discuss the clinical presentation and workup of this case, and we present a comparative analysis of tuberculosis cases associated with anti-TNF-α reported in Colombia during the last 10 years emphasizing on the diagnosis and treatment of latent tuberculosis. PMID: 29668128 [PubMed - in process]
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
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Source: Advances in Cancer Research - Category: Cancer & Oncology Authors: Tags: Adv Cancer Res Source Type: research
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Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
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Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
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