3 Evolutionary Scientists Win Nobel Chemistry Prize

(STOCKHOLM) — Three researchers who “harnessed the power of evolution” to produce enzymes and antibodies that have led to a new best-selling drug and biofuels won the Nobel Prize in chemistry on Wednesday. Frances Arnold of the California Institute of Technology was awarded half of the 9-million-kronor ($1.01 million) prize, while the other half will be shared by George Smith of the University of Missouri and Gregory Winter of the MRC molecular biology lab in Cambridge, England. The Royal Swedish Academy of Sciences, which chose the winners, said Arnold, 62, conducted the first directed evolution of enzymes, whose uses include “more environmentally friendly manufacturing of chemical substances such as pharmaceuticals and the production of renewable fuels.” BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the #NobelPrize in Chemistry 2018 with one half to Frances H. Arnold and the other half jointly to George P. Smith and Sir Gregory P. Winter. pic.twitter.com/lLGivVLttB — The Nobel Prize (@NobelPrize) October 3, 2018 Smith, 77, developed a method to evolve new proteins and Winter used the method to evolve antibodies, which are disease-fighting proteins in the blood. The first pharmaceutical based on Winter’s work was approved for use in 2002 and is employed to treat rheumatoid arthritis, psoriasis and inflammatory bowel diseases, the academy said. The chemical name of the drug is adalimumab, which has se...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized nobel prize onetime Source Type: news

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AbstractWhile the inactivation mutations that eliminate JAK3 function lead to the immunological disorders such as severe combined immunodeficiency, activation mutations, causing constitutive JAK3 signaling, are known to trigger various types of cancer or are responsible for autoimmune diseases, such as rheumatoid arthritis, psoriasis, or inflammatory bowel diseases. Treatment of hyperactivated JAK3 is still an obstacle, due to different sensibility of mutation types to conventional drugs and unwanted side effects, because these drugs are not absolutely specific for JAK3, thus inhibiting other members of the JAK family, ...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin ’s lymphoma and consists of three subtypes: activated B-cell (ABC), germinal center B-cell (GBC), and primary mediastinal B-cell (PMB). Despite advances in the front-line therapy for DLBCL, approximately one-third of patients will relapse. Substantially worse outcomes have been reported for patien ts diagnosed with ABC DLBCL and treated with standard chemoimmunotherapy, suggesting the need for novel strategies that improve treatment outcomes.ABC DLBCL cell survival depends largely upon NF- κB signaling being constitutively active. The ...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
In this study we extended our previous research synthesizing a series of multi-target cinnamic acids from the corresponding aldehydes with suitable 4-OH/Br substituted phenyl acetic acid by Knoevenagel condensation. The final products 1i, 3i, 3ii, 4i, 6i, 6ii, and 7i were obtained in high yields (52–98%) Their structures were verified spectrometrically, while their experimentally lipophilicity was determined as RM values. The novel derivatives were evaluated for their antioxidant activity using DPPH, hydroxyl radical, superoxide anion and ABTS+•, anti-lipid peroxidation and soybean lipoxygenase inhibitio...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Conclusions: The risk of new cancer or cancer recurrence among patients with a history of cancer and use of anti-TNF therapy is similar to the risk with nonbiological disease modifying therapies. These results support the use of anti-TNF medications in select populations despite prior diagnosis of cancer.
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin ’s lymphoma and consists of three subtypes: activated B-cell (ABC), germinal center B-cell (GBC), and primary mediastinal B-cell (PMB). Despite advances in the front-line therapy for DLBCL, approximately one-third of patients will relapse. Substantially worse outcomes have been reported for patien ts diagnosed with ABC DLBCL and treated with standard chemoimmunotherapy, suggesting the need for novel strategies that improve treatment outcomes.ABC DLBCL cell survival depends largely upon NF- κB signaling being constitutively active. The ...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
We report the case of a 68-year-old man with Crohn's disease, who developed  disseminated tuberculosis due to anti-TNF-α immunosuppressive therapy. The diagnosis was based on the histopathological findings and molecular biology assays.We discuss the clinical presentation and workup of this case, and we present a comparative analysis of tuberculosis cases associated with anti-TNF-α reported in Colombia during the last 10 years emphasizing on the diagnosis and treatment of latent tuberculosis. PMID: 29668128 [PubMed - in process]
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
Abstract Subtraction hybridization identified genes displaying differential expression as metastatic human melanoma cells terminally differentiated and lost tumorigenic properties by treatment with recombinant fibroblast interferon and mezerein. This approach permitted cloning of multiple genes displaying enhanced expression when melanoma cells terminally differentiated, called melanoma differentiation associated (mda) genes. One mda gene, mda-7, has risen to the top of the list based on its relevance to cancer and now inflammation and other pathological states, which based on presence of a secretory sequence, chr...
Source: Advances in Cancer Research - Category: Cancer & Oncology Authors: Tags: Adv Cancer Res Source Type: research
Authors: Santangelo C, Vari R, Scazzocchio B, De Sanctis P, Giovannini C, D'Archivio M, Masella R Abstract Altered inflammatory response characterizes chronic immune-mediated inflammatory diseases (IMID) such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, and psoriasis. Accumulating evidence indicates that regular consumption of extra virgin olive oil (EVOO), the main source of fat in the Mediterranean diet, is associated with a reduced risk of developing chronic degenerative disorders such cardiovascular diseases, type 2 diabetes and cancer. The beneficial ef...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Publication date: Available online 3 November 2017 Source:Autoimmunity Reviews Author(s): Kassem Sharif, Abdulla Watad, Nicola Luigi Bragazzi, Micheal Lichtbroun, Howard Amital, Yehuda Shoenfeld Physical activity, by definition, is any skeletal muscle body movement that results in energy expenditure. In the last few decades, a plethora of scientific evidences have accumulated and confirmed the beneficial role of physical activity as a modifiable risk factor for a wide variety of chronic diseases including cardiovascular diseases (CVDs), diabetes mellitus and cancer, among others. Autoimmune diseases are a heterogeneous gr...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Publication date: Available online 28 May 2017 Source:Autoimmunity Reviews Author(s): G. Gravina, C. Wasen, M.J. Garcia-Bonete, M. Turkkila, M.C. Erlandsson, S. Töyrä Silfverswärd, M. Brisslert, R. Pullerits, K.M. Andersson, G. Katona, M.I. Bokarewa Survivin is a protein functionally important for cell division, apoptosis, and possibly, for micro-RNA biogenesis. It is an established marker of malignant cell transformation. In non-malignant conditions, the unique properties of survivin make it indispensable for homeostasis of the immune system. Indeed, it is required for the innate and adaptive immune respon...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
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