Tattoo health warning for people with weakened immune systems

A woman with cystic fibrosis and lung transplants suffered chronic pain for three years after she had a tattoo on her thighGetting a tattoo if you have a weakened immune system could put you at risk of complications, doctors have warned. The caution comes after a woman with cystic fibrosis and lung transplants developed thigh and knee pain after having body art inked on her leg.Doctors say those taking immunosuppressant drugs should take precautions if considering body art. These medicines are often given after an organ transplant or to treat autoimmune conditions such as Crohn ’s disease, lupus or rheumatoid arthritis. Others who may have weak immune systems include those with chronic long-term conditions such as diabetes.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Tattoos Medical research Immunology Biochemistry and molecular biology Health Cystic fibrosis Diabetes Source Type: news

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Publication date: 18 April 2019Source: Cell, Volume 177, Issue 3Author(s): Luca A. Lotta, Jacek MokrosiƄski, Edson Mendes de Oliveira, Chen Li, Stephen J. Sharp, Jian’an Luan, Bas Brouwers, Vikram Ayinampudi, Nicholas Bowker, Nicola Kerrison, Vasileios Kaimakis, Diana Hoult, Isobel D. Stewart, Eleanor Wheeler, Felix R. Day, John R.B. Perry, Claudia Langenberg, Nicholas J. Wareham, I. Sadaf FarooqiSummaryThe melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. We functionally characterized 61 MC4R variants identified in 0.5 million people from UK Biobank and examined their a...
Source: Cell - Category: Cytology Source Type: research
Publication date: Available online 18 April 2019Source: NeurocomputingAuthor(s): Hai Xie, Haijun Lei, Yejun He, Baiying LeiAbstractHuman Epithelial-2 (HEp-2) cell images play an important role for the detection of antinuclear autoantibodies (ANA) in autoimmune diseases. Segmentation is the primary step for classification, further treatment and diagnosis. However, the staining patterns and scales of HEp-2 specimen images have different variances, which still make segmentation quite a challenging task. To solve it, we propose a novel deeply supervised full convolutional network (DSFCN) for robust segmentation of different HE...
Source: Neurocomputing - Category: Neuroscience Source Type: research
Authors: Wang L, Liu K Abstract Optogenetics is an emerging field, which uses light and molecular genetics to manipulate the activity of live cells by expressing light-sensitive proteins. With the discovery of bacteriorhodopsin, a light-sensitive bacterial protein, in 1971 Oesterhelt and Stoeckenius laid the pavement of optogenetics. However, the cross-integration of different disciplines is a little more than a decade old. The toolbox contains fluorescent sensors and optogenetic actuators which enable visualization of signaling events and manipulation of cellular activities, respectively. Neuropathic pain is a pai...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Conclusion: Based on the results obtained, the Turkish version of the PRWHE questionnaire was found to be a valid and reliable scale and it is recommended for the evaluation of patient-based pain and disability level in routine clinical practice. PMID: 30997792 [PubMed - in process]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Conclusion: We concluded that atopy was detected in more than one-third of adult non-CF BR patients. This study demonstrated that non-CF BR patients might have AR; it might be important to be aware of nasal symptoms in non-CF BR patients. PMID: 30997791 [PubMed - in process]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Authors: Ghoneum MH, Gimzewski JK, Ghoneum AD, Agrawal S Abstract The hydroferrate fluid MRN-100, an iron-based compound with potent antioxidant characteristics, was examined to identify its possible anti-inflammatory effects on human dendritic cells (DCs) in vitro. Human monocyte-derived DCs were treated with MRN-100 at two concentrations (50 and 100 μL/mL) for 24 h and then stimulated with or without lipopolysaccharides (LPS). The expression of DC maturation markers was assessed by flow cytometry and the production of cytokines was determined by enzyme-linked immunosorbent assay (ELISA). Function...
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
This study evaluated the effects of HIV infection on nasal carriage of Staphylococcus aureus, staphylococcal peritonitis, and catheter infection rates in patients with end-stage renal failure managed with continuous ambulatory peritoneal dialysis (CAPD). METHODS: Sixty HIV-positive and 59 HIV-negative CAPD patients were enrolled and followed up for up to 18 months. S. aureus nasal carriage (detected by nasal swab culture), Staphylococcal peritonitis (diagnosed by clinical presentation, and CAPD effluent Staphylococcal culture and white blood cell count ≥100 cells/µL), and catheter infections (including ...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
CONCLUSION: Providing adequate preoperative information to the patient about regional anesthesia will increase overall satisfaction and will assure the patient feels safe during the perioperative period. CLINICAL TRIAL REGISTRATION NUMBER: NCT03476278. PMID: 30995331 [PubMed - in process]
Source: Agri Dergisi - Category: Anesthesiology Tags: Agri Source Type: research
Authors: Gula G, Ketenci A Abstract Rotator cuff calcific tendinitis is a common shoulder disorder that usually subsides spontaneously. Some patients, however, do not show any improvement in the pain after conservative treatment for an extended period of time. The aim of this report was to demonstrate the improvement in a patient with calcific tendinitis of infraspinatus following treatment with platelet-rich plasma (PRP). Although the efficacy of PRP therapy in this condition is uncertain, it can be an effective treatment option in refractory cases. PMID: 30995330 [PubMed - in process]
Source: Agri Dergisi - Category: Anesthesiology Tags: Agri Source Type: research
CONCLUSION: The results of this study revealed no additional benefit to USSS in block success in comparison with US alone. Considering the feeling of discomfort and pain due to nerve stimulation, it was concluded that use of US alone may be preferred to combination use. PMID: 30995328 [PubMed - in process]
Source: Agri Dergisi - Category: Anesthesiology Tags: Agri Source Type: research
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