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4 trends in epilepsy research and care

Despite the fact that epilepsy is the third most common brain disorder — affecting an estimated one percent of children — there’s still much we don’t know about this condition. In fact, in about 75 percent of cases, epilepsy has no known cause. Research is crucial to help physicians learn more about the roots of epilepsy in children and develop potential treatments for it. “One third of our patients have treatment-refractory epilepsy. Unless we try to discover what causes an individual’s epilepsy, we can not take a personalized or precision approach to treatment. Parents should know that we’re not just accepting the status quo in epilepsy,” says Dr. Annapurna Poduri, a neurologist in the Epilepsy Center at Boston Children’s Hospital. “We’re continuing to investigate many different aspects of this disease, with the goal of improving patient care.” Here, Dr. Poduri shares four trends in epilepsy research and care, which families can learn more about at the upcoming Day of Science at Boston Children’s, presented by the CURE foundation. Comorbidity considerations A diagnosis of epilepsy can be challenging enough, but many children with this condition also have other disorders, which can have an impact on treatment and quality of life. Known as comorbidities, these diseases occur along with epilepsy. Some of the more common comorbidities in epilepsy include intellectual disabilities, motor impairments, ...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & Conditions Dr. Annapurna Poduri epilepsy epilepsy center seizures Source Type: news

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Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Gastroenterology News Source Type: news
Authors: Lee K, Han JW, Kim KW Abstract Differentiating early Alzheimer's disease (AD) from depression with cognitive impairment is challenging in the elderly. To develop a model for differentiating these two conditions using electroencephalography (EEG), we enrolled 11 patients with early probable AD and 11 age- and cognitive function-matched patients with major depressive disorder (MDD) and compared the EEG relative powers of 9 scalp regions. Compared to the MDD group, the AD group had a higher global theta relative power (p=0.021). In the MDD group, beta relative power was higher in the mid-central region than i...
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
CONCLUSION: In this study we demonstrated evidences of genetic association between the Per3 gene and BD. The results of association between the Per3 gene and BD in our sample may bring additional evidence to the former findings of association between the Per3 gene and BD. PMID: 29042894 [PubMed]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
In this study, we explored the prevalence rates of depression among the ten most prevalent cancers in South Korea using a national patient sample. METHODS: This was a 1-year cross-sectional study using a national patient sample provided by the South Korean National Health Insurance in 2011. We selected all patients who had received ICD-10 codes of the 10 most prevalent cancers and major depressive disorder. Afterwards, the cancer and depression groups were merged and analyzed. RESULTS: The MDD prevalence rate was highest in lung cancer (11.0%), followed by non-Hodgkin's lymphoma (9.2%), prostate (9.1%), bladder (8....
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
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Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Publication date: Available online 6 March 2017 Source:Molecular Genetics and Metabolism Author(s): Deborah A. Bilder, Joyce A. Kobori, Jessica L. Cohen-Pfeffer, Erin M. Johnson, Elaina R. Jurecki, Mitzie L. Grant Adults with phenylketonuria (PKU) may experience neurologic and psychiatric disorders, including intellectual disability, anxiety, depression, and neurocognitive dysfunction. Identifying the prevalence and prevalence ratios of these conditions will inform clinical treatment. This nested, case-controlled study used International Classification of Diseases, Ninth Revision (ICD-9) codes from the MarketScan® ins...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
ConclusionsiVNS appears to have positive modulatory long‐term effects on headache and affective/cognitive head pain perception in patients with drug‐resistant focal epilepsy, thus deserving further attention.
Source: Neuromodulation: Technology at the Neural Interface - Category: Biotechnology Authors: Tags: Clinical Research Source Type: research
Co-morbid conditions frequently occur in pediatric headaches and may significantly affect their management. Co-morbidities that have been associated with pediatric headaches include attention-deficit/hyperactivity disorder, autism, developmental disabilities, depression, anxiety, epilepsy, obesity, infantile colic, atopic disorders, inflammatory bowel disease and irritable bowel syndrome. The goal of this review is to elucidate common comorbidities associated with pediatric headache, thereby empowering child neurologists to identify common triggers and tailor management strategies that address headache and associated comorbidities.
Source: Seminars in Pediatric Neurology - Category: Neurology Authors: Source Type: research
Comorbid conditions frequently occur in pediatric headaches and may significantly affect their management. Comorbidities that have been associated with pediatric headaches include attention-deficit or hyperactivity disorder, autism, developmental disabilities, depression, anxiety, epilepsy, obesity, infantile colic, atopic disorders, inflammatory bowel disease, and irritable bowel syndrome. The goal of this article is to elucidate common comorbidities associated with pediatric headache, thereby empowering child neurologists to identify common triggers and tailor management strategies that address headache and associated comorbidities.
Source: Seminars in Pediatric Neurology - Category: Neurology Authors: Source Type: research
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Source: The Icarus Project - Navigating the Space Between Brilliance and Madness - Category: Psychiatry Authors: Source Type: blogs
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