Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease

Conclusion:
Exposure to a xenobiotic during early development induced persistent fat accumulation via hypomethylation of lipogenic genes. Moreover, increased Nrf2 recruitment to the Srebp-1c promoter in livers of BPA-exposed mice was observed. Overall, the underlying mechanisms described a broader impact beyond BPA exposure and can be applied to understand other models of NAFLD. https://doi.org/10.1289/EHP664

Received: 15 June 2016
Revised: 28 January 2017
Accepted: 31 January 2017
Published: 04 August 2017
Address correspondence to A.L. Slitt, Biomedical and Pharmaceutical Sciences, University of Rhode Island, 7 Greenhouse Rd., Kingston, RI 02881 USA. Telephone: [phone]. Email: [e-mail]
Supplemental Material is available online (https://doi.org/10.1289/EHP664).
The authors declare they have no actual or potential competing financial interests.
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Source: EHP Research - August 5, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research