Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease

Conclusion: Exposure to a xenobiotic during early development induced persistent fat accumulation via hypomethylation of lipogenic genes. Moreover, increased Nrf2 recruitment to the Srebp-1c promoter in livers of BPA-exposed mice was observed. Overall, the underlying mechanisms described a broader impact beyond BPA exposure and can be applied to understand other models of NAFLD. https://doi.org/10.1289/EHP664 Received: 15 June 2016 Revised: 28 January 2017 Accepted: 31 January 2017 Published: 04 August 2017 Address correspondence to A.L. Slitt, Biomedical and Pharmaceutical Sciences, University of Rhode Island, 7 Greenhouse Rd., Kingston, RI 02881 USA. Telephone: (401) 874-5020. Email: aslitt@uri.edu Supplemental Material is available online (https://doi.org/10.1289/EHP664). The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Supplemental Material PDF (1.4 MB) Note to readers with disabilities: EHP has provided a 508-conformant table of...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

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Source: Tubal Reversal Blog - Category: Reproduction Medicine Authors: Tags: Endometrial Ablation Greencastle Pennsylvania Source Type: blogs
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