Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease

Conclusion: Exposure to a xenobiotic during early development induced persistent fat accumulation via hypomethylation of lipogenic genes. Moreover, increased Nrf2 recruitment to the Srebp-1c promoter in livers of BPA-exposed mice was observed. Overall, the underlying mechanisms described a broader impact beyond BPA exposure and can be applied to understand other models of NAFLD. https://doi.org/10.1289/EHP664 Received: 15 June 2016 Revised: 28 January 2017 Accepted: 31 January 2017 Published: 04 August 2017 Address correspondence to A.L. Slitt, Biomedical and Pharmaceutical Sciences, University of Rhode Island, 7 Greenhouse Rd., Kingston, RI 02881 USA. Telephone: (401) 874-5020. Email: aslitt@uri.edu Supplemental Material is available online (https://doi.org/10.1289/EHP664). The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Supplemental Material PDF (1.4 MB) Note to readers with disabilities: EHP has provided a 508-conformant table of...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

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Background and Purpose: Accidents, both intentional and unintentional, are one of the leading causes of death and disability for children around the world and impose a heavy financial burden on the health care system of societies. The aim of the present st...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Road accidents are one of the causes of disability, injury and death. As per the latest road accident data released by the Ministry of Road Transport&Highways (MoRTH), the total number of accidents increased by 2.5 percent from 4,89,400 in 2014 to 5,01,4...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news
Conclusions: LTL is associated with an obesity phenotype in AA women. Tailored intervention is needed to ameliorate the burden of excess adiposity and subsequent cellular aging. PMID: 32742149 [PubMed - in process]
Source: Ethnicity and Disease - Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
CONCLUSIONS: A higher risk of a negative outcome for mother and baby is seen among women born in Somalia compared to women born in Sweden. We suggest it may be worthwhile to investigate whether a Somali-adapted intervention with proactivity concerning self-monitoring of fetal movements may improve pregnancy outcomes in this migrant population. PMID: 32744184 [PubMed - in process]
Source: Global Health Action - Category: International Medicine & Public Health Tags: Glob Health Action Source Type: research
CONCLUSION: In this study, approximately half of the participants were aware of safe sex and had knowledge of STIs. There is a need to have comprehensive sexual education, particularly emphasising family planning, STIs, and HIV/AIDS for all grades in school. PMID: 32741352 [PubMed - in process]
Source: Global Health Action - Category: International Medicine & Public Health Tags: Glob Health Action Source Type: research
CONCLUSION: The study helps to understand the views and perceptions of adolescents and key informants on gender equality and gender-based violence. Three main areas require more effort and greater investment to improve adolescent sexual and reproductive health: knowledge and use of contraceptives, gender inequality, and autonomy. There is poor knowledge of contraceptive methods, indicating a need to further integrate comprehensive sexual education, introduced in primary school, and to increase investment in training and monitoring teachers. PMID: 32741350 [PubMed - in process]
Source: Global Health Action - Category: International Medicine & Public Health Tags: Glob Health Action Source Type: research
CONCLUSION: In the case of unintended or unwanted pregnancy, adolescents must also have adequate knowledge and access to safe abortion and associated counselling services. This study suggests a need to increase sexual and reproductive health literacy including information about safe abortion. This requires a holistic approach to sexual education and needs the support and involvement of adolescents themselves as well as parents, community members and healthcare workers. PMID: 32741348 [PubMed - in process]
Source: Global Health Action - Category: International Medicine & Public Health Tags: Glob Health Action Source Type: research
Authors: Santisouk P, Hansana V, Thanh Huong N Abstract BACKGROUND: Pregnancy health literacy (PHL) among teenagers is considered a major protective factor for teenage pregnancy. In Lao PDR, 18% of girls aged 15-19 have begun childbearing and 15% of maternal deaths occur to teenage girls, particularly in rural areas. OBJECTIVE: The aim of this study was to describe PHL and its related factors among teenagers in Kaysone district. METHOD: This was a cross-sectional study conducted at Oudomvilay and Kheuakhaokat in Kaysone district in January 2019. The Teenage Pregnancy Health Literacy (TPHL) score was collect...
Source: Global Health Action - Category: International Medicine & Public Health Tags: Glob Health Action Source Type: research
This article was first published by the UN Chronicle on 6 July 2020.   Follow @IPSNewsUNBureau !function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?'http':'https';if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+'://platform.twitter.com/widgets.js';fjs.parentNode.insertBefore(js,fjs);}}(document, 'script', 'twitter-wjs'); The post The UN General Assembly: A 75-Year Journey Towards the Future We Want appeared first on Inter Press Service. Excerpt: Tijjani Muhammad-Bande is President of the 74th Session of the United Nations General Assembly and Permanent Representat...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Gender Global Headlines Health Human Rights Humanitarian Emergencies IPS UN: Inside the Glasshouse Peace TerraViva United Nations UN at 75 Source Type: news
Publication date: Available online 3 August 2020Source: Pregnancy HypertensionAuthor(s): Xiaosong Yuan, Lingna Zhou, Bin Zhang, Huiyan Wang, Bin Yu, Jun Xu
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
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