HIV Did Not Stop Me From Having a Biological Child

On Monday, April 15, 2013, at 8:00 a.m., my life changed forever. My wife, Kasiah, and I welcomed our first child, a healthy girl named Finley Elizabeth Banks, into this world. She was perfect. But the journey to have a healthy, HIV-free biological child began many years before Finley’s birth. MoreFederal Appeals Court Strikes Down Utah's Gay Marriage Ban NBC NewsJessica N. Turner: Moms, Put on That Swimsuit Huffington PostShould the Cops Get to Look at Your Cellphone? NBC NewsParty's Over? GOP's Insurgents Take More Punches NBC NewsUruguay eliminates Italy; Did Suarez bite again? Sports IllustratedIn 1981, when I was two years old, I was diagnosed with Bilateral Wilms’ tumors, a cancer of the kidneys, which had also spread to both of my lungs. The prognosis was grim; treatment was aggressive. My tiny toddler body fought a battle that required 15 months of chemotherapy, radiation therapy, and surgeries that required multiple blood transfusions. Unknowingly, I was transfused with blood that infected me with HIV. Ten years later, having lived through a cancer-free childhood, doctors screened my blood during a routine oncology check-up. They discovered that I was HIV-positive. In 1991, the epidemic was still raging, and very little was known about how HIV/AIDS infected and affected children. Pediatric treatment options were limited — AZT (the drug that drives the plot of Dallas Buyers Club) had only been approved for young patients the previous year. Support fr...
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized AIDS research Family & Parenting Fatherhood HIV medicine Science Source Type: news

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ConclusionsA single institution KBP model can be applied as a QC tool for multi-institutional clinical trials to improve overall plan quality and provide decision-support to determine the need for anatomy-based dosimetric trade-offs.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Our data show that TBX1 is frequently inactivated by promoter methylation, and functions as a potential tumor suppressor in thyroid cancer through inhibiting the activities of PI3K/AKT and MAPK/ERK signaling pathways. PMID: 30543152 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Authors: Bondeelle L, Bergeron A Abstract INTRODUCTION: Progress in allogeneic hematopoietic stem cell transplantation (HSCT) procedures have been associated with improved survival in HSCT recipients. However, they have also brought to light organ-specific complications, especially pulmonary complications. In this setting, pulmonary complications are consistently associated with poor outcomes, and improved management of these complications is required. Areas covered: We review the multiple infectious and noninfectious lung complications that occur both early and late after allogeneic HSCT. This includes the descrip...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis. Oncol Rep. 2018 Nov 01;: Authors: Akagi J, Baba H Abstract Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, the present study investigated whether it restores exhausted CD8+ T ce...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
sFRP1 exerts effects on gastric cancer cells through GSK3β/Rac1‑mediated restraint of TGFβ/Smad3 signaling. Oncol Rep. 2018 Oct 31;: Authors: Peng JX, Liang SY, Li L Abstract Secreted frizzled‑related protein 1 (sFRP1) is an inhibitor of canonical Wnt signaling; however, previous studies have determined a tumor‑promoting function of sFRP1 in a number of different cancer types. A previous study demonstrated that sFRP1 overexpression was associated with an aggressive phenotype and the activation of transforming growth factor β (TGFβ) signaling. sFRP1 overexpression and...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
In conclusion, H19 promoted gefitinib resistance of NSCLC cells by packaging into exosomes. Therefore, exosomal H19 may be a promising therapeutic target for EGFR+ NSCLC patients. PMID: 30542738 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Pectolinarigenin inhibits non‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway. Oncol Rep. 2018 Oct 02;: Authors: Xu F, Gao X, Pan H Abstract Lung cancer is the principal cause of cancer‑-associated mortality. Pectolinarigenin (Pec) reportedly has effective antitumor activity against certain cancer types. Phosphatase and tensin homolog (PTEN) is a well‑known tumor suppressor and serves a vital role in cancer progression. However, the effect of Pec on non‑small cell lung cancer (NSCLC) cell proliferation and metastasis, and the underlying mechanism, has not ye...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Ubiquitin‑specific protease 7 promotes osteosarcoma cell metastasis by inducing epithelial‑mesenchymal transition. Oncol Rep. 2018 Oct 31;: Authors: Zeng Q, Li Z, Zhao X, Guo L, Yu C, Qin J, Zhang S, Zhang Y, Yang X Abstract Osteosarcoma (OS) is the most common primary malignant bone tumour among adolescents and young adults; however, its molecular pathogenesis has not been completely elucidated. Ubiquitin‑specific protease 7 (USP7), a member of the deubiquitinating enzyme family, plays a role in the malignancy process of various cancer types by targeting the key oncoprotein; however, its biologi...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Kobayashi S, Saio M, Fukuda T, Kimura K, Hirato J, Oyama T Abstract Nuclear size and shape are important components in the diagnosis of pathological specimens. However, a qualitative evaluation is typically applied rather than a quantitative evaluation technique. In the present study, we sought to evaluate the nuclear morphological characteristics of lung adenocarcinoma using whole-slide imaging (WSI) and computer-assisted image analysis (IA). We evaluated the nuclear characteristics of 106 cases of surgically resected lung adenocarcinoma according to Feulgen staining and immunohistochemistry (IHC) for the...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Identification of biomarkers for the prediction of relapse‑free survival in pediatric B‑precursor acute lymphoblastic leukemia. Oncol Rep. 2018 Nov 02;: Authors: Jing W, Li J Abstract B‑precursor acute lymphoblastic leukemia (B‑ALL) is the most common cancer diagnosed in children and adolescents. Despite the fact that the 5‑year survival rate has increased from 60 to 90%, approximately a quarter of children suffer from relapse with poor outcome. To improve the clinical management of B‑ALL, there is an urgent need for prognostic biomarkers for the prediction of B‑ALL outcomes. In the prese...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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