Anti-Alcoholism Drug from 1950s Shows Promise in Treating Mesothelioma

An FDA-approved drug used since the 1950s to treat alcoholism has shown considerable promise in suppressing the spread of mesothelioma and enhancing the effectiveness of chemotherapy, according to a recently published study. Scientists and clinicians conducted the study, published April 2014 in PLOS ONE, to examine the effects of copper-enhanced disulfiram (DSF-Cu) on malignant pleural mesothelioma cells in vitro and on animal models. Arun K. Rishi, Ph.D., of the Karmanos Cancer Institute at Wayne State University, said the findings could clear a path to more effective treatment options for the cancer caused almost exclusively by exposure to asbestos fibers. "A drug like this could have the potential to localize the disease and prevent its spread," Rishi told "That's very exciting." Long-time mesothelioma specialist Harvey Pass, M.D., director of thoracic surgery at New York University Medical Center, also co-authored the study. Effective against Other Cancers Previous studies had shown the effectiveness of disulfiram against breast, lung and colon cancer cells, leading to the anticipation of positive results with mesothelioma. The next step before possible approval by the U.S. Food and Drug Administration (FDA) for the treatment of mesothelioma would be a Phase I clinical trial. Disulfiram, which is sold under the brand name Antabuse, works in the treatment of alcoholism on a molecular level by changing the way alcohol is metabolized...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Treatment & Doctors Source Type: news

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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Oncology Research and Treatment - Category: Cancer & Oncology Source Type: research
Authors: Saud B, Paudel G Abstract Air pollution has been a major problem of 21st century for both developed and developing world. It has a negative impact on various environmental aspects which directly or indirectly affect the quality of human health. Nepal, especially Kathmandu, in the current situation, is observing rapid urbanization and various infrastructure development projects. As a result, these sorts of human activities have been responsible for increasing air pollution in an enormous rate inside Kathmandu Valley. Chronic exposure of deteriorated air increases the chance of Noncommunicable Disease (NCD) ...
Source: Journal of Environmental and Public Health - Category: Environmental Health Tags: J Environ Public Health Source Type: research
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Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) functions as a crucial regulator of metastasis in lung cancer. The aim of this study is to unravel the underlying mechanisms of lncRNA MALAT1 in non-small-cell lung cancer (NSCLC). A cohort of 36 NSCLC tumor tissues and adjacent normal tissues was collected postoperatively from patients with NSCLC. qRT-PCR was performed to detect the expression of MALAT1 in both NSCLC tissues and cell lines. Cell migration and invasion were monitored by wound healing assay and transwell invasion assay. Western blot was used to detect the expression ...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
In this study, MAP30, a ribosome-inactivating protein reported to have apoptotic effects on cancer cells, was fused with S3, an epidermal growth factor receptor (EGFR)-targeting peptide. In addition, CsA was used to investigate whether it can further promote the apoptotic effects of S3 fused MAP30 (MAP30–S3). Our result showed that the internalization of FITC-labeled MAP30–S3 was increased significantly by S3 in HeLa cells. Unexpectedly, MAP30–S3 only showed a minor decrease in the viability of EGFR-overexpressing cancer cells, including HeLa, SMMC-7721, and MGC803 (IC50>5 μmol/l). However, 2...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
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Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
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Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
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