Anti-Alcoholism Drug from 1950s Shows Promise in Treating Mesothelioma

An FDA-approved drug used since the 1950s to treat alcoholism has shown considerable promise in suppressing the spread of mesothelioma and enhancing the effectiveness of chemotherapy, according to a recently published study. Scientists and clinicians conducted the study, published April 2014 in PLOS ONE, to examine the effects of copper-enhanced disulfiram (DSF-Cu) on malignant pleural mesothelioma cells in vitro and on animal models. Arun K. Rishi, Ph.D., of the Karmanos Cancer Institute at Wayne State University, said the findings could clear a path to more effective treatment options for the cancer caused almost exclusively by exposure to asbestos fibers. "A drug like this could have the potential to localize the disease and prevent its spread," Rishi told Asbestos.com. "That's very exciting." Long-time mesothelioma specialist Harvey Pass, M.D., director of thoracic surgery at New York University Medical Center, also co-authored the study. Effective against Other Cancers Previous studies had shown the effectiveness of disulfiram against breast, lung and colon cancer cells, leading to the anticipation of positive results with mesothelioma. The next step before possible approval by the U.S. Food and Drug Administration (FDA) for the treatment of mesothelioma would be a Phase I clinical trial. Disulfiram, which is sold under the brand name Antabuse, works in the treatment of alcoholism on a molecular level by changing the way alcohol is metabolized...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Treatment & Doctors Source Type: news

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Source: Journal of Membrane Science - Category: Materials Science Source Type: research
Deliberate self-harm, encompassing suicide attempts, completed suicides, and nonsuicidal self-injurious behavior, is a global public health problem with a particularly strong impact on the world ’s youth and young adults. In the United States, suicide is the third leading cause of death among children 10 to 14 years of age and the second leading cause of death among adolescents and adults 15 to 34 years of age (1). Suicide attempts far outnumber completed suicides, and the personal, socia l, and economic costs of suicidal behavior are staggering.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Authors: Conte SC, Spagnol G, Biolo M, Confalonieri M Abstract The conventional-trans bronchial needle aspiration (c-TBNA) has been the first procedure for sampling hilar/mediastinal lymph node for the diagnosis/staging of lung cancer. In the last decade the endobronchial ultrasound trans bronchial needle aspiration (EBUS-TBNA) was introduced in clinical practice and became the first-choice exam in diagnosis and staging of lung cancer. The aim of this study was to compare the diagnostic accuracy (DA), sensitivity and adequacy of c-TBNA and EBUS-TBNA. It was a retrospective and observational multicenter study. The f...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Publication date: 18 April 2019Source: Cell, Volume 177, Issue 3Author(s): Wantong Yao, Anirban MaitraIn this issue of Cell, Lytle et al. (2019) integrate functional genomic approaches to identify molecular dependencies of pancreatic cancer stem cells that may be exploited therapeutically. The comprehensive analysis reveals an unexpected role for retinoic acid receptor-related orphan receptor gamma (RORγ), a T-cell-associated transcription factor, in defining the stemness and the aggressive behavior of pancreatic cancer.
Source: Cell - Category: Cytology Source Type: research
In conclusion, our results indicated that CEP55 played an important role in promoting the invasion and migration of U251 cell and self-renewal of glioma stem like cells which might be a new therapeutic target for glioma.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 18 April 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Caroline Park, Joshua Rosenblat, Elisa Brietzke, Zihang Pan, Yena Lee, Bing Cao, Hannah Zuckerman, Anastasia Kalantarova, Roger S. McIntyreAbstractEnvironmental stressors, such as childhood maltreatment, have been recognized to contribute to the development of depression. Growing evidence suggests that epigenetic changes are a key mechanism by which stressors interact with the genome leading to stable changes in DNA structure, gene expression, and behaviour. The current review aimed to evaluate the relationship between...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Publication date: Available online 18 April 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Lisa M. ChristianAbstractBirth prior to full term is a substantial public health issue. In the US, ˜400,000 babies per year are born preterm (1 million are early term (37–386/7 weeks). Birth prior to full term confers risk both immediate and long term, including neonatal intensive care, decrements in school performance, and increased mortality risk from infancy through young adulthood. Risk for low birth weight and preterm birth are 1.5-2 times greater among African Americans versus Whites. Psychosocial str...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Publication date: Available online 18 April 2019Source: NeurocomputingAuthor(s): Pengyi Hao, Kun You, Haozhe Feng, Xinnan Xu, Fan Zhang, Fuli Wu, Peng Zhang, Wei ChenAbstractEarly detection of lung cancer is the most promising path to increase the chance of survival for patients. Accurate lung nodule detection in computed tomography (CT) images is a crucial step in diagnosing lung cancer. CNN based CADe systems diagnose lung nodules in two stages by using one network for detection and another following network for classification or false positive reduction. Besides costly construction, two-stage systems can only find a sin...
Source: Neurocomputing - Category: Neuroscience Source Type: research
Authors: Simsek FS, Arslan M, Dag Y Abstract In some non-small cell lung cancer (NSCLC) patients, lipid-poor adrenal adenomas cannot be adequately differentiated from metastases using imaging methods. Invasive diagnostic procedures also have a low negative predictive value (NPV) in such cases. The current study aims to establish a specific and clinically practical metabolic parameter for lipid-poor adrenal lesions (ALs) in NSCLC patients. This diagnostic approach may prevent unnecessary abdominal enhanced computed tomography (CT), magnetic resonance imaging, or invasive diagnostic procedures. Sixty-four NSCLC patie...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Authors: Niu JC, Ma N, Liu W, Wang PJ Abstract Recent studies showed that the activation of prostaglandin (PG) receptor EP1 promotes cell migration and invasion in different cancers. The aim of this study was to investigate the role of EP1 in the proliferation of osteosarcoma (OS) cells in vitro and in vivo. EP1 mRNA and protein levels were analyzed by real-time RT-PCR and Western blot, respectively in human OS cell lines MG63, OS732, U-2OS, HOS and SAOS-2 compared to human fetal osteoblastic hFOB 1.19 cells. MG63 cells were treated with PGE2, EP1 specific agonist 17-PT-PGE2, 17-PT-PGE2 + EP1 specific antagonist SC...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
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