A design thinking approach to primary ovarian insufficiency.

A design thinking approach to primary ovarian insufficiency. Panminerva Med. 2016 Nov 09; Authors: Martin LA, Porter AG, Pelligrini VA, Schnatz PA, Jiang X, Kleinstreuer N, Hall JE, Verbiest S, Olmstead J, Fair R, Falorni A, Persani L, Rajkovic A, Mehta K, Nelson LM Abstract Most clinicians are not prepared to provide integrated personal care to address all the clinical needs of women with primary ovarian insufficiency. Design thinking is an engineering methodology used to develop and evaluate novel concepts for systems operation. Here we articulate the need for a seamlessly integrated mobile health system to support genomic research as well as patient care. We also review the pathophysiology and management of primary ovarian insufficiency. Molecular understanding regarding the pathogenesis is essential to developing strategies for prevention, earlier diagnosis, and appropriate management of the disorder. The syndrome is a chronic disorder characterized by oligo/amenorrhea and hypergonadotropic hypogonadism before age 40 years. There may be significant morbidity due to 1) depression and anxiety related to the loss of reproductive hormones and infertility, 2) associated autoimmune adrenal insufficiency or hypothyroidism, and 3) reduced bone mineral density and increased risk of cardiovascular disease related to estrogen deficiency. Approximately 5 to 10% of women with primary ovarian insufficiency conceive and have a child. Women who ...
Source: Panminerva Medica - Category: Journals (General) Tags: Panminerva Med Source Type: research