Conducting in-home functional analyses of aggression and self-injury exhibited by boys with fragile X syndrome - Monlux KD, Pollard JS, Bujanda Rodriguez AY, Hall SS.
OBJECTIVE: Boys with fragile X syndrome (FXS) are at increased risk for exhibiting aggression and self-injury that can be extremely disruptive to families. Few studies, however, have examined the extent to which social-environmental factors can influence t... (Source: SafetyLit)
Source: SafetyLit - November 1, 2021 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Zynerba initiates late-stage study of potential treatment for fragile X syndrome
The rare condition is the most common known single-gene cause of autism spectrum disorder. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - September 13, 2021 Category: American Health Authors: John George Source Type: news

What Are Some Etiologies for Intellectual Disability?
Discussion “Intellectual disability (ID) is a neurodevelopmental disorder that is characterized by deficits in both intellectual functioning and adaptive function whose onset is in the development period.” Global developmental delay (GDD) is used to describe children from 0-5 years old with significant delays in 2 or more developmental areas. These delays may be transient but up to 2/3 of children with GDD will have ID. Overall 1-3% of the general population has ID which makes it very common. Most children with GDD/ID are identified because of delays in meeting milestones or general academic achievement. ID pat...
Source: PediatricEducation.org - May 3, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

An Alzheimer's Drug May Boost Cognition In People With Fragile X Syndrome
An experimental medicine seems to ease symptoms of Fragile X syndrome, a genetic disorder that is the most common inherited cause of intellectual disabilities and autism.(Image credit: Richard J. Green/Science Source) (Source: NPR Health and Science)
Source: NPR Health and Science - April 30, 2021 Category: Consumer Health News Authors: Jon Hamilton Source Type: news

Genome-editing tool TALEN outperforms CRISPR-Cas9 in tightly packed DNA
(University of Illinois at Urbana-Champaign, News Bureau) Researchers used single-molecule imaging to compare the genome-editing tools CRISPR-Cas9 and TALEN. Their experiments revealed that TALEN is up to five times more efficient than CRISPR-Cas9 in parts of the genome, called heterochromatin, that are densely packed. Fragile X syndrome, sickle cell anemia, beta-thalassemia and other diseases are the result of genetic defects in the heterochromatin. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 27, 2021 Category: International Medicine & Public Health Source Type: news

Zynerba provides progress report on its potential Fragile X syndrome therapy
Zynerba Pharmaceuticals, a developer of synthetic and transdermal cannabinoid therapies for rare neuropsychiatric disorders, said Thursday it expects to begin a "pivotal" late-stage clinical trial of its experimental Fragile X syndrome therapy Zygel late next year. The leaders of the 13-year-old Devon company said they believe positive results from the trial, to confirm previous study results, would be sufficient to support the submission of a new drug application for Zygel to treat Fragile X. Zynerba's… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - December 17, 2020 Category: Biotechnology Authors: John George Source Type: news

New drug moves closer to becoming first treatment for Fragile X Syndrome
(University at Buffalo) A new drug discovered through a research collaboration between the University at Buffalo and Tetra Therapeutics took a major step toward becoming a first-in-class treatment for Fragile X Syndrome, a leading genetic cause of autism. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 11, 2020 Category: International Medicine & Public Health Source Type: news

What Causes Fragile X Syndrome?
Title: What Causes Fragile X Syndrome?Category: Diseases and ConditionsCreated: 11/21/2020 12:00:00 AMLast Editorial Review: 11/21/2020 12:00:00 AM (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - November 21, 2020 Category: Pediatrics Source Type: news

Fish give insight on sound sensitivity in autism
(University of Queensland) Scientists at The University of Queensland used zebrafish that carry the same genetic mutations as humans with Fragile X syndrome and autism, and discovered the neural networks and pathways that produce the hypersensitivities to sound in both species. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 10, 2020 Category: International Medicine & Public Health Source Type: news

Bullying victimization in young females with fragile-X-syndrome - Joga-Elvira L, Jacas C, Joga ML, Roche-Mart ínez A, Brun-Gasca C.
The aim of this study is to investigate the risk associated with girls with fragile X syndrome (FXS) suffering bullying in the role of a victim and its effects on their adaptive behavior, socialization style, and emotional state. A neuropsychological asses... (Source: SafetyLit)
Source: SafetyLit - September 21, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Yale researchers find a cause and possible treatment for Fragile X
Fragile X syndrome — a disorder of the X chromosome — is the leading cause of autism and the primary genetic driver of intellectual disability. (Source: Yale Science and Health News)
Source: Yale Science and Health News - September 3, 2020 Category: Universities & Medical Training Source Type: news

Examining the specificity of forms and functions of aggressive behavior in boys with fragile X syndrome - Britton TC, Wilkinson EH, Hall SS.
Limited information is available concerning the specificity of the forms and functions of aggressive behavior exhibited by boys with fragile X syndrome (FXS). To investigate these relationships, we conducted indirect functional assessments of aggressive be... (Source: SafetyLit)
Source: SafetyLit - July 4, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Findings weaken notion that size equals strength for neural connections
(Picower Institute at MIT) Among a new study's many surprises about synaptic plasticity may be a new approach to addressing Fragile X syndrome: Finding and targeting a " Protein X " that appears to promote shrinkage of dendritic spines. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - June 30, 2020 Category: International Medicine & Public Health Source Type: news

Unexpected mental illnesses found in a spectrum of a rare genetic disorder
(University of California - Davis Health) UC Davis MIND Institute researchers found an unexpected spectrum of mental illnesses in patients with a rare gene mutation. These patients had a " double hit " condition that combined features and symptoms of fragile X syndrome and premutation disorder, in addition to a range of psychiatric symptoms. The findings revealed the need for clinicians to consider the complexities of the co-existing conditions of patients with both psychological and fragile X associated disorders. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 24, 2020 Category: International Medicine & Public Health Source Type: news

Scientific breakthrough toward treatment of Fragile X syndrome
(University of Calgary) Scientists at the University of Calgary have made a discovery that could lead to treatment of Fragile X syndrome (FXS), the leading genetic cause of autism. The study, involving mouse models, shows promise of translating to a treatment for people. Those with FXS are missing a protein vital to brain development called FMRP. The researchers used a fragment of FMRP which was able to cross the blood-brain barrier and restore the protein to normal levels. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 2, 2020 Category: International Medicine & Public Health Source Type: news