Animal research suggests Zika could affect the adult brain

Conclusion This experimental study in mice investigated the effect of Zika virus on adult brain cells, hoping to increase knowledge of the long-term outcomes of Zika virus on the adult brain. Zika was thought to be a short-term virus for adult humans without many long-term effects. The researchers' experiments in mice found that the two small areas in the adult mouse brain containing cells active in cell division can be susceptible to pronounced Zika infection leading to cell death and reduced cell division. While healthy humans may be able to mount an effective immune response to the virus, it is possible that immunocompromised humans may be susceptible in ways demonstrated by the mice. However, as the authors point out, the study only used a single virus strain, a single mouse strain and was at a single point in time. There is more information needed before the implications for humans are understood. Future studies are needed in infected humans to describe the effects of the Zika virus on the adult brain. Public Health England provide an up-to-date overview of the current state of the Zika virus outbreaks in the Americas, as well as specific advice for certain groups, such as pregnant women or women planning to become pregnant. Links To The Headlines Zika virus may cause long-term memory damage, similar to Alzheimer's disease. The Daily Telegraph, August 18 2016 Could Zika devastate the brain like Alzheimer's? Virus attacks the area linked to learning and memory. Da...
Source: NHS News Feed - Category: Consumer Health News Tags: Neurology Source Type: news

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The objectives of this article are the following: 1) to examine fibromyalgia and somatic symptom disorder analogy. 2) to discuss stress-evoked neuropathic pain sexual dimorphism, and 3) to propose a neuropathic pathogenesis that may explain how stressed women could develop fibromyalgia. Recent research demonstrates a clear link between fibromyalgia and small fibre neuropathy. Dorsal root ganglia contain the small nerve fibre nuclei. In rodents, physical, chemical, or environmental stressors lead to dorsal root ganglia phenotypic changes and to hyperalgesia. This phenomenon is much more frequent in females. Prolactin, oestr...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: van Campen C(MC, Rowe PC, Verheugt FWA, Visser FC Abstract OBJECTIVES: Muscle pain and fibromyalgia (FM) are common among individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We recently demonstrated that during orthostatic stress testing, adults with ME/CFS reported increased pain. In the current study, we hypothesised that pain pressure thresholds (PPT) would decrease and temporal summation (windup) would increase after head-up tilt testing (HUT), and that the presence of co-morbid FM would be associated with greater change in both measures. METHODS: We studied adult ME/CFS p...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
CONCLUSIONS: The AQUEOUS study assessed for the first time the unmet needs of young PAPS patients, enabling the development of a future "youth-focused" strategy to reduce disease burden. PMID: 32940209 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Number of cases worldwide passes 30 million; Victoria announces 21 new Covid-19 cases and seven more deaths; UK faces possible second national lockdown. Follow all the developmentsMutant virus: should we be worried that Sars-CoV-2 is changing ?UK entering second wave of virus, Johnson warns‘Shocking’: Trump under fire from ex-adviser for Covid failures5.31amBSTThe Victorian Department of Health and Human Services has put out some more information on the latest case numbers today.The 21 cases is the lowest number of new cases since 24 June.Of the 834 current active cases in Victoria:5.12amBSTThe Australian minis...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Science World news Source Type: news
Abstract Large-scale production of induced pluripotent stem cells (iPSCs) is essential for the treatment of a variety of clinical indications. However, culturing enough iPSCs for clinical applications is problematic due to their sensitive pluripotent state and dependence on a supporting matrix. Developing stem cell bioprocessing strategies that are scalable and meet clinical needs requires incorporating methods that measure and monitor intrinsic markers of cell differentiation state, developmental status, and viability in real time. In addition, proper cell culture modalities that nurture the growth of high-qualit...
Source: Trends in Biotechnology - Category: Biotechnology Authors: Tags: Trends Biotechnol Source Type: research
Contributors : Amanda McQuade ; Jonathan HasselmannSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensscRNA-sequencing of human xenotransplanted microglia isogenic for TREM2 after exposure to amyloid pathology
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Haowei Jiang ; Morgan Newman ; Stephen Pederson ; Michael LardelliSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioAlzheimer ’s disease is the most common form of age-related dementia. At least 15 mutations in the human gene PRESENILIN 2 (PSEN2) have been found to cause familial Alzheimer’s disease (fAD). Zebrafish possess an orthologous gene, psen2, and present opportunities for investigation of PRESENILIN function r elated to Alzheimer’s disease. The most prevalent and best characterized fAD mutation in PSEN2 is N141I. The equivalent codon in zebrafish...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research
Abstract Mesenchymal-to-epithelial transition (MET) describes the ability of loosely associated migratory cells to form a more adherent sheet-like assembly of cells. MET is a conserved motif occurring throughout organogenesis and plays a key role in regeneration and cancer metastasis, and is the first step in producing induced pluripotent stem cells (iPSCs). To resolve fundamental biological questions about MET, its relation to epithelial-to-mesenchymal transition, and to explore MET's role in tissue assembly and remodeling requires live models for MET that are amenable to experimentation. Many cases of clinically...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
eau E Abstract The epithelial-mesenchymal transition (EMT) converts coherent epithelial structures into single cells. EMT is a dynamic cellular process that is not systematically completed (not all EMTs lead to single cells) and reversible (cells can re-epithelialize). EMT is orchestrated at multiple levels from transcription, to posttranslational modifications, to protein turnover. It involves remodeling of polarity and adhesion and enhances migratory capabilities. During physiological events such as embryogenesis or wound healing EMT is used to initiate cell migration, but EMT can also occur in pathological sett...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
State ’s chief health officer says it was ‘inappropriate’ to single out migrant community in CaseyVictoria ’s chief health officer, Brett Sutton, has apologised for comments he made singling out Melbourne’s Afghan community in relation to a Covid-19 outbreak in Casey.Sutton made the apology as the Victorian premier, Daniel Andrews, announced 21 new coronavirus cases and seven more deaths in the state on Saturday. It was the lowest number of new Covid-19 cases in the state since 24 June.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Australia news Coronavirus outbreak Victoria Infectious diseases Science Daniel Andrews Australian politics Victorian politics Queensland Queensland politics Source Type: news
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