Animal research suggests Zika could affect the adult brain

Conclusion This experimental study in mice investigated the effect of Zika virus on adult brain cells, hoping to increase knowledge of the long-term outcomes of Zika virus on the adult brain. Zika was thought to be a short-term virus for adult humans without many long-term effects. The researchers' experiments in mice found that the two small areas in the adult mouse brain containing cells active in cell division can be susceptible to pronounced Zika infection leading to cell death and reduced cell division. While healthy humans may be able to mount an effective immune response to the virus, it is possible that immunocompromised humans may be susceptible in ways demonstrated by the mice. However, as the authors point out, the study only used a single virus strain, a single mouse strain and was at a single point in time. There is more information needed before the implications for humans are understood. Future studies are needed in infected humans to describe the effects of the Zika virus on the adult brain. Public Health England provide an up-to-date overview of the current state of the Zika virus outbreaks in the Americas, as well as specific advice for certain groups, such as pregnant women or women planning to become pregnant. Links To The Headlines Zika virus may cause long-term memory damage, similar to Alzheimer's disease. The Daily Telegraph, August 18 2016 Could Zika devastate the brain like Alzheimer's? Virus attacks the area linked to learning and memory. Da...
Source: NHS News Feed - Category: Consumer Health News Tags: Neurology Source Type: news

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Publication date: Available online 14 December 2019Source: Chemico-Biological InteractionsAuthor(s): Ryan N. Serio, Lorraine J. GudasAbstractEthanol (EtOH) is a recreationally ingested compound that is both teratogenic and carcinogenic in humans. Because of its abundant consumption worldwide and the vital role of stem cells in the formation of birth defects and cancers, delineating the effects of EtOH on stem cell function is currently an active and urgent pursuit of scientific investigation to explicate some of the mechanisms contributing to EtOH toxicity. Stem cells represent a primordial, undifferentiated phase of devel...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Quick question. Sorry about another salary thread but I am asking a specific question. Anybody working in private practice in NYC or within 30 min driving distance? Please feel free to post here or PM me about starting salary range. Thank you.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
It's that time of year. How much Xmas bonus do you fork out for your staff, manager, mid levels, etc?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Publication date: Available online 14 December 2019Source: Orthopaedics &Traumatology: Surgery &ResearchAuthor(s): Alessio Bernasconi, Cecilia Iervolino, Rosa D’Alterio, François Lintz, Shelain Patel, Francesco SadileAbstractBackgroundThe role of subtalar arthroereisis (STA) for treating flexible flatfoot (FFF) in children is controversial. We hypothesized that (1) STA provided significant radiographic correction of low longitudinal arch and forefoot abduction in paediatric FFF and that (2) mid-term clinical outcomes were satisfactory and comparable to a normal population.MethodsA retrospective compara...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
We report the clinical findings, imaging features, surgery and histological analyses of primary synovial chondromatosis in glenohumeral joint, biceps tendon sheath and subcoracoid bursa in a child, aged 14. Primary synovial chondromatosis is characteristized by multiple calcified nodules in joints, tendons or bursa areas. The condition is more usual in large joints, in particular in lower extremities. It may be symptomless until the volume of chondromatosis has increased to such an extent that it results in pain, locking symptom or palpable mass. The treatment is removal of the loose bodies and potentially synovectomy, in ...
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
This study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid (UDCA).MethodsThis prospective, case control study included 88 pregnant women (44 women with ICP and 44 healthy controls). The primary end points were the perinatal outcome and the response to UDCA therapy. A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to UDCA therapy.ResultsWomen with ICP had significantly higher serum syndecan-1 (1.27 ± 0.36 ng/...
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
CONCLUSIONS: The use of this novel cartilage restoration surgical technique provides excellent clinical, functional, and MRI-based outcomes in young, active individuals with full-thickness cartilage or osteochondral defects. LEVEL OF EVIDENCE: Level IV-Therapeutic case series. PMID: 31835970 [PubMed - in process]
Source: Journal of Orthopaedic Surgery - Category: Orthopaedics Authors: Tags: J Orthop Surg (Hong Kong) Source Type: research
CONCLUSION: TPTD treatment prevented ovariectomy-induced bone loss and ovariectomy-induced mechanical hyperalgesia in hind limbs, and it suppressed CGRP and TRPV1 expressions in DRG neurons. These results suggest that TPTD is useful for the treatment of osteoporotic pain in postmenopausal women. PMID: 31833446 [PubMed - in process]
Source: Journal of Orthopaedic Surgery - Category: Orthopaedics Authors: Tags: J Orthop Surg (Hong Kong) Source Type: research
ConclusionsOral zinc therapy was found to be an adjunct in reducing burning sensation and lesion size in symptomatic OLP.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
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