Lifespan.io Project: Help to Crowdfund the Sinclair Lab NMN Calorie Restriction Mimetic Lifespan Study in Mice

The Lifespan.io crew have launched their latest longevity science crowdfunding project in partnership with the Sinclair lab at Harvard: the goal is to raise funds for a novel calorie restriction mimetic mouse life span study based on research published last year. You might recall that David Sinclair was the researcher behind Sirtris, one of the more hyped initiatives in sirtuin research, though far from the only one. Over the past twenty years a lot of work has gone into trying to understand the activities of proteins and pathways thought to be important in the extended longevity produced by calorie restriction in short-lived species, sirtuins among their number, and there was considerable enthusiasm for drug development along these lines a decade ago. A few companies were founded, such as Sirtris, but while some people made a bunch of money, nothing came out of this save for a greater appreciation of the complexities of cellular metabolism and a mountain of new data. Research on sirtuins didn't halt following the realization that this wasn't a fast path to modestly slowing the aging process. It continues, along with a great many other, similar investigations into the detailed operation of mammalian biochemistry, and how it changes in response to circumstances. In fact much of aging research and longevity science even now is arguably just a thin excuse to bring funds into the grand endeavor of mapping cellular metabolism, in much the same way that Alzheimer's research is use...
Source: Fight Aging! - Category: Research Authors: Tags: Activism, Advocacy and Education Source Type: blogs