Perinatal Exposure to Polychlorinated Biphenyls (PCBs) and Child Neurodevelopment: A Comprehensive Systematic Review of Outcomes and Methodological Approaches

CONCLUSIONS: Significant methodological, clinical and statistical heterogeneity existed in the included studies. Adverse effects on cognitive development and attention were observed in middle childhood. Inconclusive evidence prevailed regarding other neurodevelopmental aspects due to limited studies. Future research could further explore sex-specific associations and evaluate associations at lower exposure levels post-PCB ban in the US. It should also consider OH-PCB metabolites, co-pollutants, mixtures, and their potential interactions.PMID:38615789 | DOI:10.1016/j.envres.2024.118912

Source: Environmental Research - April 14, 2024 Category: Environmental Health Authors: Arin A Balalian Jeanette A Stingone Linda G Kahn Julie B Herbstman Richard I Graeve Steven D Stellman Pam Factor-Litvak Source Type: research