Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates

CONCLUSIONS: Limited evidence is available on opioid administration for postoperative pain in newborn infants compared to either placebo, other opioids, or paracetamol. We are uncertain whether tramadol reduces mortality compared to placebo; none of the studies reported pain scores, major neurodevelopmental disability, cognitive and educational outcomes in children older than five years old, retinopathy of prematurity, or intraventricular hemorrhage. We are uncertain whether fentanyl reduces mortality compared to tramadol; none of the studies reported pain scores, major neurodevelopmental disability, cognitive and educational outcomes in children older than five years old, retinopathy of prematurity, or intraventricular hemorrhage. We are uncertain whether morphine reduces pain compared to paracetamol; none of the studies reported major neurodevelopmental disability, cognitive and educational outcomes in children more than five years old, all-cause mortality during initial hospitalization, retinopathy of prematurity, or intraventricular hemorrhage. We identified no studies comparing opioids versus non-pharmacological interventions.PMID:36870076 | PMC:PMC9983301 | DOI:10.1002/14651858.CD014876.pub2

Source: Cochrane Database of Systematic Reviews - March 4, 2023 Category: General Medicine Authors: Mari Kinoshita Katarzyna S Stempel Israel Junior Borges do Nascimento Matteo Bruschettini Source Type: research