Marked and prolonged serotonin toxicity in a tramadol-poisoned patient with a pharmacokinetic study - Bianconi G, Malissin I, Labat L, Khoudour N, Houz é P, Pallet N, Megarbane B, Declèves X.
BACKGROUND: Tramadol poisoning rarely causes serotonin toxicity, which mechanisms remain poorly understood. We investigated alterations in tramadol pharmacokinetics in a tramadol-poisoned patient who presented with marked and prolonged serotonin toxicity. ... (Source: SafetyLit)
Source: SafetyLit - July 25, 2021 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Codeine and tramadol use in athletes: a potential for abuse - Zandonai T, Escorial M, Peir ó AM.
Analgesic use by athletes is common (Overbye, 2020). It has been observed that athletes used analgesics up to four times more often than their age-matched general population (Holgado et al., 2018a). Notably, codeine and tramadol are not included in the WAD... (Source: SafetyLit)
Source: SafetyLit - July 3, 2021 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Acute tramadol ingestion with transient acute kidney injury in an adolescent female - Mike TB, DeVault H, Blackford MG.
Renal toxicity has been described with tramadol overdoses; however, it is typically associated with rhabdomyolysis, multiorgan failure and/or mortality. Our patient was a 16-year-old female who was evaluated following an intentional tramadol ingestion, est... (Source: SafetyLit)
Source: SafetyLit - May 28, 2021 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

DR MICHAEL MOSLEY: Should doctors now prescribe dummy pills to ease pain?
DR MICHAEL MOSLEY: Deaths from taking high-strength painkillers, such as tramadol and codeine, have doubled over the past ten years, there is clearly a need for safe and effective alternatives. (Source: the Mail online | Health)
Source: the Mail online | Health - April 16, 2021 Category: Consumer Health News Source Type: news

Women in England almost twice as likely as men to be prescribed opiate painkillers
Experts worried about high use of drugs such as codeine and tramadol after prescriptions rose during Covid pandemic‘I was told to live with it’: women tell of doctors dismissing their painWomen in England are almost twice as likely as men to be prescribed powerful and potentially addictive opiate painkillers, prompting experts to warn that female pain is overly medicated and not properly investigated.The number of people prescribed drugs such as codeine and tramadol – often used for chronic pain – rose to 1.18 million in the first 10 months of 2020. Of these, 745,047 were women and 434,697 were men,...
Source: Guardian Unlimited Science - April 16, 2021 Category: Science Authors: Sarah Marsh and Pamela Duncan Tags: Women's health Drugs Science Society UK news Source Type: news

Study shows opioid use among US patients with knee osteoarthritis costs 14 billion dollars in societal costs
(Wiley) Although guidelines do not recommend use of opioids to manage pain for individuals with knee osteoarthritis, a recent study published early online in Arthritis Care& Research, an official journal of the American College of Rheumatology and the Association of Rheumatology Professionals, estimates that 858,000 Americans use opioids such as tramadol and oxycodone for their knee pain, equating to $14 billion in lifetime opioid-related societal costs, or nearly $0.5 billion annually. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

Machine learning algorithms to predict seizure due to acute tramadol poisoning - Behnoush B, Bazmi E, Nazari SH, Khodakarim S, Looha MA, Soori H.
This study was designed to develop and evaluate machine learning algorithms for predicting seizure due to acute tramadol poisoning, identifying high-risk patients and facilitating appropriate clinical decision-making. METHODS: Several... (Source: SafetyLit)
Source: SafetyLit - February 8, 2021 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

Nigeria: Increased Risk As Drug Smugglers Rebrand Tramadol
[ISS] Manufacturers in India have rebranded the opioid Tramadol to Tafrodol so as to evade detection by customs officials at Nigeria's ports and borders. While the name change makes the drug look like Tramadol, Tafrodol contains two ingredients that should not be combined and can reportedly cause respiratory infection, coma and even instant death. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - January 28, 2021 Category: African Health Source Type: news

FDA Drug Safety Communication: FDA restricts use of prescription codeine pain and cough medicines and tramadol pain medicines in children; recommends against use in breastfeeding women
FDA is restricting the use of codeine and tramadol medicines in children. Codeine is approved to treat pain and cough, and tramadol is approved to treat pain. These medicines carry serious risks, including slowed or difficult breathing and death, which appear to be a greater risk in children younger than 12 years and must not be used in these children. These medicines should also be limited in some older children. Single-ingredient codeine and all tramadol-containing products are FDA-approved only for use in adults. We are also recommending against using codeine and tramadol medicines in breastfeeding mothers due to possib...
Source: FDA Center for Drug Evaluation and Research - What's New - January 7, 2021 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Assessment of tramadol blood concentration in cases of acute tramadol overdose - Tawfik HM, Abd El Wahab MB.
Tramadol is a synthetic analgesic drug that has been used for acute and chronic pain. It has a potential risk of addiction and overdoses due to its common illegal abuse. The analgesic effect of tramadol is dose dependent and in medical literature no study ... (Source: SafetyLit)
Source: SafetyLit - December 28, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Avenue Therapeutics gets regulatory update for intravenous tramadol, says Cipla
In October this year, Avenue Therapeutics Inc had received a complete response letter (CRL) from the USFDA which stated that the regulator has determined that it cannot approve the application for IV tramadol in its present form. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - December 18, 2020 Category: Pharmaceuticals Source Type: news

Cumberland County Man Admits Conspiring to Distribute Opioids, Launder Millions of Dollars in Drug Proceeds
FDA OCI, Alton Chatmon, Bridgeton NJ, guilty plea, Tramadol, synthetic opioid, butalbital, prescription pills, money laundering, drug trafficking proceeds, shell companies, pharmacist, suspended license, wire transfer, conspiracy, Fioricet, fictitious businesses, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - December 17, 2020 Category: Medical Law Authors: DOJ Source Type: news

Real-world data on nonmedical use of tramadol from patients evaluated for substance abuse treatment in the NAVIPPRO Addiction Severity Index-Multimedia Version (ASI-MV ®) network - Green JL, Dailey-Govoni T, Butler SF.
INTRODUCTION: Drug safety studies regarding comparative risk of different opioid compounds are important as providers and regulatory agencies in the United States continue to balance pain management with an ongoing opioid epidemic. OBJECTIVE: The aim o... (Source: SafetyLit)
Source: SafetyLit - November 14, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Accidental tramadol ingestion in children admitted in tertiary care centre - Sruthi V, Narendra AMVR.
BACKGROUND: Tramadol use has been increasing in the adult and pediatric population. Practitioners must be alert because Tramadol misuse can lead to severe intoxication in which respiratory failure and seizures are frequent. Overdoses can lead to death. We ... (Source: SafetyLit)
Source: SafetyLit - September 22, 2020 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Qdolo (Tramadol Hydrochloride Oral Solution) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 17, 2020 Category: Drugs & Pharmacology Source Type: news

Identification of biomarkers for the detection of subtle brain injury after cannabis and/or tramadol administration - Abdel-Salam OME, Sleem AA, Youness ER, Omara EA.
There is a need to identify biomarkers which could indicate the occurrence of brain injury in drug abuse.... (Source: SafetyLit)
Source: SafetyLit - September 14, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Nalbuphine vs. Tramadol After Ambulatory Surgery Nalbuphine vs. Tramadol After Ambulatory Surgery
Is intravenous nalbuphine hydrochloride, which generally has less side effects than tramadol, as effective as tramadol for the treatment of postoperative pain after ambulatory surgery?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 14, 2020 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

FDA Approves Qdolo (tramadol hydrochloride) Oral Solution for the Management of Severe Pain
ATHENS, Ga., Sept. 8, 2020 /PRNewswire/ -- Athena Bioscience, LLC, a specialty pharmaceutical company, announced today that the U.S. Food and Drug Administration (FDA) has approved Qdolo™ (tramadol hydrochloride) Oral Solution 5mg/1mL C-IV, an... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - September 8, 2020 Category: Drugs & Pharmacology Source Type: news

A case of tramadol-induced psychosis on a background of mixed substance use resulting in serious violence - Rakov J, Carroll A.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - August 28, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Fatal accident involving a welder employed by a shipping container company, associated with the use of tramadol and antidepressant agents - Sanz-Gallen P, Amig ó de Bonet N, Canals ML, Martí-Amengual G.
The widespread use of opioids for the treatment of moderate or severe acute and chronic pain has become a public health problem due to the physical and psychological dependence and tolerance they produce. The increasingly higher doses that patients require... (Source: SafetyLit)
Source: SafetyLit - July 4, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

I.V. Dex vs. Tramadol for Shivering After Spinal Anesthesia: I.V. Dex vs. Tramadol for Shivering After Spinal Anesthesia:
This study compared advantages and disadvantages of dexmedetomidine vs. tramadol on post-spinal anesthesia shivering.BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 30, 2020 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Nigeria: Non-Medical Use of Prescription Drugs Among Skilled Workers - a Pilot Study
[The Conversation Africa] More than ever, the world is facing a challenge of non-medical use of prescription drugs among people of all ages, genders and occupations. Evidence shows that pharmaceutical opioids (tramadol, codeine, or morphine), barbiturates such as pentobarbital sodium, benzodiazepines (diazepam and alprazolam), and amphetamines are the most common types of prescription medication used in a non-medical context. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 25, 2020 Category: African Health Source Type: news

Former Norfolk Doctor Sentenced for Role in Internet Pharmacy Organization
Norfolk VA, physician, sentence, internet pharmacy, Lawrence Ryan, forfeit, controlled substance, misbranded, drug, RX Limited, fioricet, butalbital, carisoprodol, soma, tramadol, ultram, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - June 24, 2020 Category: Medical Law Authors: DOJ Source Type: news

Tramadol Mortality Risk in Osteoarthritis Could Outweigh Benefits Tramadol Mortality Risk in Osteoarthritis Could Outweigh Benefits
Patients with OA treated with tramadol had a 20%-50% higher risk of dying during the first year of treatment than did patients who were treated with NSAIDs in results of a large population-based study.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 8, 2020 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Clinical characteristics distinguishing tramadol-using adolescents from other substance-using adolescents in an out-patient treatment setting - Holmstedt A, Olsson MO, Hakansson A.
BACKGROUND: Non-medical Prescription Opioid Use (NMPOU) has increased worldwide during the last decades, and specifically, tramadol misuse may represent a novel pattern of substance use among adolescents. The present study aims to analyze characteristics d... (Source: SafetyLit)
Source: SafetyLit - April 28, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Nurse Given Prison Sentence for Drug Theft and Tampering
nurse, prison, drug theft, tampering, Katie Boll, Manchester IA, morphine, hydrocodone, oxycodone, codeine, tramadol, nursing home, mouthwash, fraud, deception, subterfuge, 48 months prison (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - April 7, 2020 Category: Medical Law Authors: DOJ Source Type: news

Tramadol use and public health consequences in Iran: a systematic review and meta-analysis - Rostam-Abadi Y, Gholami J, Amin-Esmaeili M, Safarcherati A, Mojtabai R, Ghadirzadeh MR, Rahimi H, Rahimi-Movaghar A.
BACKGROUND AND AIMS: Misuse of tramadol, an opioid prescription analgesic, is known as a public health challenge globally. We aimed to systematically review studies on the prevalence of non-prescribed use, regular tramadol use and dependence, tramadol-indu... (Source: SafetyLit)
Source: SafetyLit - March 25, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

tramadol (Ultram)
Title: tramadol (Ultram)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 2/12/2020 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - February 12, 2020 Category: Rheumatology Source Type: news

Tramadol Linked to Increased Hip Fracture Risk in Older Adults Tramadol Linked to Increased Hip Fracture Risk in Older Adults
An increased risk of falls is speculated as a possible factor in the fracture risk.Medscape Medical News (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - February 11, 2020 Category: Rheumatology Tags: Diabetes & Endocrinology News Source Type: news

Tramadol Linked to Increased Hip Fracture Risk in Adults Aged & #8805;50
WEDNESDAY, Feb. 5, 2020 -- For older adults, initiation of tramadol is associated with an increased risk for hip fracture compared with initiation of codeine, ibuprofen, and other commonly used nonsteroidal anti-inflammatory drugs, according to a... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 5, 2020 Category: Pharmaceuticals Source Type: news

Letter to the Editor: Don't Throw Tramadol on the Junk Heap Yet
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - February 1, 2020 Category: Emergency Medicine Tags: Letter to the Editor Source Type: news

How tramadol, touted as safer opioid, became 3rd world peril
Mass abuse of the drug tramadol spans continents, from India to Africa to the Middle East. The problem is that advocates claimed it was a safer opioid, relieving pain with little risk of abuse (Source: ABC News: Health)
Source: ABC News: Health - December 14, 2019 Category: Consumer Health News Tags: Health Source Type: news

`Safer opioid’ has sparked a crisis in vulnerable countries
Mass abuse of the drug tramadol spans continents, from India to Africa to the Middle East. The problem is that advocates claimed it was a safer opioid, relieving pain with little risk of abuse (Source: ABC News: Health)
Source: ABC News: Health - December 13, 2019 Category: Consumer Health News Tags: Health Source Type: news

Tramadol is an odd, unpredictable opioid, scientists say
Scientists describe tramadol as a messy and unpredictable man-made opioid (Source: ABC News: Health)
Source: ABC News: Health - December 13, 2019 Category: Consumer Health News Tags: Health Source Type: news

Another opioid crisis is raging through the developing world
Mass abuse of the drug tramadol spans continents, from India to Africa to the Middle East. The problem is that advocates claimed it was a safer opioid, relieving pain with little risk of abuse (Source: ABC News: Health)
Source: ABC News: Health - December 13, 2019 Category: Consumer Health News Tags: Health Source Type: news

News: No Reason to Choose Tramadol over Morphine
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - November 1, 2019 Category: Emergency Medicine Tags: News Source Type: news

Ultram (tramadol) Side Effects
Title: Ultram (tramadol) Side EffectsCategory: MedicationsCreated: 10/21/2019 12:00:00 AMLast Editorial Review: 10/21/2019 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - October 21, 2019 Category: Drugs & Pharmacology Source Type: news

Houston TX Man Sentenced to 27 Months for Shipping Misbranded Prescription Drugs to Oldham County
Dhaval Jerambhai Dholaria, Houston TX, zolpidem tartrate, Ambien, Schedule IV controlled substance, tramadol, opioid, diazepam, Valium, zolpidem tartrate, clonazepam, Klonopin, Soma, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - October 9, 2019 Category: Medical Law Authors: DOJ Source Type: news

Eight Defendants Arrested for Distributing Millions of Opioid Pills Imported from India
Ezhil Sezhian Kamaldoss, Harpreet Singh, Parthiban Narayanasamy, Baljeet Singh, Deepak Manchanda, Gulab Gulab, Mukul Chugh, Vikas M. Verma,Tramadol, synthetic opioid, large-scale importation, misbranded controlled substances, Queens warehouse, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - October 4, 2019 Category: Medical Law Authors: DOJ Source Type: news

DEA Uncovers a Flood of Painkillers Reaching Rural Alaska by Mail
Describes an operation led by the Drug Enforcement Administration that uncovered nearly 45,000 pills of Tramadol mailed to Alaska in 45 days. Contains information on the mild opioid and ways enforcement agencies are addressing substance abuse in rural communities. (Source: News stories via the Rural Assistance Center)
Source: News stories via the Rural Assistance Center - September 20, 2019 Category: Rural Health Source Type: news

Use of Pain Reliever Tramadol May Up Risk for Hypoglycemia
MONDAY, Sept. 9, 2019 -- Use of the widely prescribed opioid tramadol is associated with a greater risk for developing hypoglycemia compared with almost every other opioid, according to a study published online Aug. 28 in Scientific Reports. Tigran... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 9, 2019 Category: Pharmaceuticals Source Type: news

Safer opioid Tramadol linked to increased risk of low blood sugar
People who use the drug Tramadol, commercially marketed as ConZip or Ultram, have 10 times the risk of developing hypoglycemia, a condition marked by a sharp drop in blood sugar, according to new research. (Source: Health News - UPI.com)
Source: Health News - UPI.com - August 28, 2019 Category: Consumer Health News Source Type: news

Legal opioid tramadol 'could cause blood-sugar levels to drop to deadly levels'
Scientists from the University of California, San Diego, analysed more than 12 million adverse events reports collected by the FDA between January 2004 and March 2019. (Source: the Mail online | Health)
Source: the Mail online | Health - August 28, 2019 Category: Consumer Health News Source Type: news

Nigeria: Customs Uncovers N5 Billion Tramadol, Codeine in Lagos Warehouse
[Daily Trust] Lagos -Several individuals are currently undergoing interrogation at the Nigeria Customs Service's Federal Operations Unit (FOU) in Ikeja, Lagos, over their suspected involvement in the importation of N5 billion worth Tramadol and codeine found in a warehouse in Lagos. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - August 19, 2019 Category: African Health Source Type: news

Individual short-acting opioids and the risk of opioid-related adverse events in adolescents - Chung CP, Callahan ST, Cooper WO, Dupont WD, Murray KT, Franklin AD, Hall K, Dudley JA, Stein CM, Ray WA.
PURPOSE: Hydrocodone, codeine, oxycodone, and tramadol are frequently prescribed to adolescents for moderate pain related to minor trauma or dental, surgical, or medical procedures. Pharmacokinetic and pharmacodynamic differences between these opioids coul... (Source: SafetyLit)
Source: SafetyLit - August 19, 2019 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Houston, TX Man Pleads Guilty to Mailing Misbranded Prescription Drugs to Oldham County
Dhaval Jerambhai Dholaria, Houston, Texas, zolpidem tartrate, Ambien, Oldham County, Kentucky, India, tramadol, diazepam, Valium, zolpidem tartrate, clonazepam, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - August 16, 2019 Category: Medical Law Authors: DOJ Source Type: news

Indian Businessman Charged with Drug Importation, Smuggling, and Money Laundering Offenses
Jeetendra Harish Belani, aka Jeetu, Mumbai, India, Schedule II controlled substance, Schedule IV controlled substance, smuggle drugs, LeeHPL Ventures, LeeHPL, Tramadol, Carisoprodol, Modafinil, William Kulakevich, Julia Fees, Etizolam, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - August 16, 2019 Category: Medical Law Authors: DOJ Source Type: news

Use of Codeine and Tramadol Products in Breastfeeding Women - Questions and Answers
Answers to questions about certain opioid medications and their effects on breastfed infants (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - August 1, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

November 28, 2017: Champaign, Illinois, Resident Guilty of Producing and Selling Over 80,000 Homemade Tramadol Capsules to Customers Without Verifying Prescriptions
(Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - July 9, 2019 Category: Medical Law Authors: FDA Source Type: news