Recommendations for pharmacogenetic testing in clinical practice guidelines in the US
CONCLUSION: A standardized approach to evaluating the evidence of clinical utility for pharmacogenetic testing may increase the inclusion and consistency of pharmacogenetic testing recommendations in clinical practice guidelines, which could benefit patients and society by increasing clinical use of pharmacogenetic testing.PMID:38652504 | DOI:10.1093/ajhp/zxae110 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - April 23, 2024 Category: Drugs & Pharmacology Authors: Daniel L Hertz Chad A Bousman Howard L McLeod Andrew A Monte Deepak Voora Lori A Orlando Rustin D Crutchley Benjamin Brown Wrenda Teeple Sara Rogers Jai N Patel Source Type: research
Recommendations for pharmacogenetic testing in clinical practice guidelines in the US
CONCLUSION: A standardized approach to evaluating the evidence of clinical utility for pharmacogenetic testing may increase the inclusion and consistency of pharmacogenetic testing recommendations in clinical practice guidelines, which could benefit patients and society by increasing clinical use of pharmacogenetic testing.PMID:38652504 | DOI:10.1093/ajhp/zxae110 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - April 23, 2024 Category: Drugs & Pharmacology Authors: Daniel L Hertz Chad A Bousman Howard L McLeod Andrew A Monte Deepak Voora Lori A Orlando Rustin D Crutchley Benjamin Brown Wrenda Teeple Sara Rogers Jai N Patel Source Type: research
Neuropathic pain: Evidence based recommendations
Presse Med. 2024 Apr 17:104232. doi: 10.1016/j.lpm.2024.104232. Online ahead of print.ABSTRACTNeuropathic pain continues to be a significant problem that lacks effective solutions for every single patient. In 2015, international guidelines (NeuPSIG) were published, while the French recommendations were updated in 2020. The purpose of this minireview is to provide an update on the process of developing evidence-based recommendations and explore potential changes to the current recommendations. Primary treatments for neuropathic pain include selective serotonin-norepinephrine reuptake inhibitors (SNRIs) such as duloxetine an...
Source: Presse Medicale - April 19, 2024 Category: General Medicine Authors: Xavier Moisset Source Type: research
Evaluation of histological and ultrastructural changes provoked by prenatal tramadol on postnatal cortical cerebellar neuronal development in rats: possible implication of Ki67, GFAP and MicroRNA-7/P53 signalling trajectories
J Mol Histol. 2024 Apr 19. doi: 10.1007/s10735-024-10189-2. Online ahead of print.ABSTRACTTramadol is a novel centrally acting analgesic. Despite, its implementation during pregnancy may impair neuronal survival and synaptic development in neonatal cerebella. The current investigation assessed the histological and ultrastructural alterations in postnatal cortical cerebellar neuronal development induced by prenatal tramadol. 30 offsprings were divided to control group I: fifteen pups born to mothers given saline from D10 till D21 of gestation. Tramadol-treated group II: fifteen pups born to mothers received tramadol HCL (50...
Source: Molecular Medicine - April 19, 2024 Category: Molecular Biology Authors: Walaa Adel Abdelmoez Source Type: research
Neuropathic pain: Evidence based recommendations
Presse Med. 2024 Apr 17:104232. doi: 10.1016/j.lpm.2024.104232. Online ahead of print.ABSTRACTNeuropathic pain continues to be a significant problem that lacks effective solutions for every single patient. In 2015, international guidelines (NeuPSIG) were published, while the French recommendations were updated in 2020. The purpose of this minireview is to provide an update on the process of developing evidence-based recommendations and explore potential changes to the current recommendations. Primary treatments for neuropathic pain include selective serotonin-norepinephrine reuptake inhibitors (SNRIs) such as duloxetine an...
Source: Presse Medicale - April 19, 2024 Category: General Medicine Authors: Xavier Moisset Source Type: research
Evaluation of histological and ultrastructural changes provoked by prenatal tramadol on postnatal cortical cerebellar neuronal development in rats: possible implication of Ki67, GFAP and MicroRNA-7/P53 signalling trajectories
AbstractTramadol is a novel centrally acting analgesic. Despite, its implementation during pregnancy may impair neuronal survival and synaptic development in neonatal cerebella. The current investigation assessed the histological and ultrastructural alterations in postnatal cortical cerebellar neuronal development induced by prenatal tramadol. 30 offsprings were divided tocontrol group I: fifteen pups born to mothers given saline from D10 till D21 of gestation.Tramadol-treated group II: fifteen pups born to mothers received tramadol HCL (50 mg/kg/day) from D10 till D21 of gestation. Pups were categorized into three subgr...
Source: Journal of Molecular Histology - April 19, 2024 Category: Laboratory Medicine Source Type: research
Adverse childhood experiences, individual ‐level risk and protective factors, and recent drug use in a community sample of Nigerian women
AbstractAdverse childhood experiences (ACEs) are associated with a wide range of health problems and health-compromising behaviors, including drug use, but are understudied in sub-Saharan Africa. Further, some data suggest that some types of ACEs are more strongly associated with outcomes than others. We investigated associations between different types of ACEs and recent drug use among 2,011 women living in Katsina State, Nigeria. This community-based survey included questions on ACE exposure, modifiable individual-level risk and promotive factors, and past-year drug use. Tobacco, cannabis, and the nonmedical use of cough...
Source: Journal of Traumatic Stress - April 16, 2024 Category: Psychiatry & Psychology Authors: Martin Osayande Agwogie,
Wendy Kliewer,
Muhammed Bashir Ibrahim Tags: RESEARCH ARTICLE Source Type: research
A Comparative Analysis of Erector Spinae Plane Block Versus Conscious Sedation in Managing Percutaneous Cholecystostomy Pain
ConclusionESPB significantly alleviates perioperative and postoperative pain in PC patients, reducing additional analgesic use and side effects. It holds promise as a key component of pain management for high-risk surgical patients.Level of EvidenceLevel 3, Non-randomized controlled cohort/follow-up study.Graphical Abstract (Source: CardioVascular and Interventional Radiology)
Source: CardioVascular and Interventional Radiology - April 15, 2024 Category: Radiology Source Type: research
Evaluation of Postoperative Pain After Cardiothoracic Surgery in Patients With and Without Significant Preoperative Anxiety: A Prospective Observational Study
CONCLUSIONS: This clinical trial demonstrated that greater than 60% of the participants presented with preoperative anxiety, the majority being young participants. Lower socioeconomic status is also a risk factor for preoperative anxiety. Patients who suffered from preoperative anxiety are more likely to have greater pain scores and analgesic needs during postsurgical assessment.PMID:38607875 | DOI:10.4103/aca.aca_175_23 (Source: Annals of Cardiac Anaesthesia)
Source: Annals of Cardiac Anaesthesia - April 12, 2024 Category: Anesthesiology Authors: Agarwal Shreya Durga P Rath Satyen Parida Hemachandren Munuswamy Sreevathsa Prasad Ramsankar Padmanabhan Source Type: research
Evaluation of Postoperative Pain After Cardiothoracic Surgery in Patients With and Without Significant Preoperative Anxiety: A Prospective Observational Study
CONCLUSIONS: This clinical trial demonstrated that greater than 60% of the participants presented with preoperative anxiety, the majority being young participants. Lower socioeconomic status is also a risk factor for preoperative anxiety. Patients who suffered from preoperative anxiety are more likely to have greater pain scores and analgesic needs during postsurgical assessment.PMID:38607875 | DOI:10.4103/aca.aca_175_23 (Source: Annals of Cardiac Anaesthesia)
Source: Annals of Cardiac Anaesthesia - April 12, 2024 Category: Anesthesiology Authors: Agarwal Shreya Durga P Rath Satyen Parida Hemachandren Munuswamy Sreevathsa Prasad Ramsankar Padmanabhan Source Type: research
Evaluation of Postoperative Pain After Cardiothoracic Surgery in Patients With and Without Significant Preoperative Anxiety: A Prospective Observational Study
CONCLUSIONS: This clinical trial demonstrated that greater than 60% of the participants presented with preoperative anxiety, the majority being young participants. Lower socioeconomic status is also a risk factor for preoperative anxiety. Patients who suffered from preoperative anxiety are more likely to have greater pain scores and analgesic needs during postsurgical assessment.PMID:38607875 | DOI:10.4103/aca.aca_175_23 (Source: Annals of Cardiac Anaesthesia)
Source: Annals of Cardiac Anaesthesia - April 12, 2024 Category: Anesthesiology Authors: Agarwal Shreya Durga P Rath Satyen Parida Hemachandren Munuswamy Sreevathsa Prasad Ramsankar Padmanabhan Source Type: research
Evaluation of Postoperative Pain After Cardiothoracic Surgery in Patients With and Without Significant Preoperative Anxiety: A Prospective Observational Study
CONCLUSIONS: This clinical trial demonstrated that greater than 60% of the participants presented with preoperative anxiety, the majority being young participants. Lower socioeconomic status is also a risk factor for preoperative anxiety. Patients who suffered from preoperative anxiety are more likely to have greater pain scores and analgesic needs during postsurgical assessment.PMID:38607875 | DOI:10.4103/aca.aca_175_23 (Source: Annals of Cardiac Anaesthesia)
Source: Annals of Cardiac Anaesthesia - April 12, 2024 Category: Anesthesiology Authors: Agarwal Shreya Durga P Rath Satyen Parida Hemachandren Munuswamy Sreevathsa Prasad Ramsankar Padmanabhan Source Type: research
Evaluation of Postoperative Pain After Cardiothoracic Surgery in Patients With and Without Significant Preoperative Anxiety: A Prospective Observational Study
CONCLUSIONS: This clinical trial demonstrated that greater than 60% of the participants presented with preoperative anxiety, the majority being young participants. Lower socioeconomic status is also a risk factor for preoperative anxiety. Patients who suffered from preoperative anxiety are more likely to have greater pain scores and analgesic needs during postsurgical assessment.PMID:38607875 | DOI:10.4103/aca.aca_175_23 (Source: Annals of Cardiac Anaesthesia)
Source: Annals of Cardiac Anaesthesia - April 12, 2024 Category: Anesthesiology Authors: Agarwal Shreya Durga P Rath Satyen Parida Hemachandren Munuswamy Sreevathsa Prasad Ramsankar Padmanabhan Source Type: research
Evaluation of Postoperative Pain After Cardiothoracic Surgery in Patients With and Without Significant Preoperative Anxiety: A Prospective Observational Study
CONCLUSIONS: This clinical trial demonstrated that greater than 60% of the participants presented with preoperative anxiety, the majority being young participants. Lower socioeconomic status is also a risk factor for preoperative anxiety. Patients who suffered from preoperative anxiety are more likely to have greater pain scores and analgesic needs during postsurgical assessment.PMID:38607875 | DOI:10.4103/aca.aca_175_23 (Source: Annals of Cardiac Anaesthesia)
Source: Annals of Cardiac Anaesthesia - April 12, 2024 Category: Anesthesiology Authors: Agarwal Shreya Durga P Rath Satyen Parida Hemachandren Munuswamy Sreevathsa Prasad Ramsankar Padmanabhan Source Type: research
In vivo effects of a selected thiourea derivative 1-(2-chlorobenzoyl)-3-(2,3-dichlorophenyl) against nociception, inflammation and gastric ulcerogenicity: Biochemical, histopathological and in silico approaches
In conclusion, these findings suggest that our test compound exhibits potent antinociceptive, anti-inflammatory properties and is devoid of ulcerogenic effects.PMID:38599058 | DOI:10.1016/j.biopha.2024.116544 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: Gowhar Ali Farrah Deeba Umer Rashid Aman Ullah Hammad Ullah Inayat Ali Khan Syed Ishtiaq Khan Amin Badshah Muhammad Arif Khan Muhammad Ayaz Maria Daglia Source Type: research
