Tramadol-related tinnitus
(Source: Reactions Weekly)
Source: Reactions Weekly - March 1, 2024 Category: Drugs & Pharmacology Source Type: research
Development and validation of a liquid chromatography –tandem mass spectrometry (LC–MS/MS) method including 25 novel synthetic opioids in hair and subsequent analysis of a Swiss opioid consumer cohort
This study investigated the prevalence and abuse patterns of novel synthetic opioids (NSOs) among Swiss opioid users by means of a validated LC –MS/MS-based hair analysis method. Among a cohort of 439 Swiss opioid users, a positivity rate for NSOs of 2.5% was found, including NSOs such as butyrylfentanyl or acrylfentanyl. These findings contribute to the development of appropriate public health and policy measures to mitigate the risks as sociated with NSO abuse. AbstractMajor public health concern is raised by the evidence that common drugs like heroin are now frequently laced or replaced with highly potent novel synthe...
Source: Drug Testing and Analysis - February 21, 2024 Category: Drugs & Pharmacology Authors: Max Polke,
Marta Concheiro,
Gail Cooper,
Christian Bogdal,
Markus R. Baumgartner,
Thomas Kr ämer,
Tina M. Binz Tags: RESEARCH ARTICLE Source Type: research
Direct anterior approach with conventional instruments versus robotic posterolateral approach in elective total hip replacement for primary osteoarthritis: a case –control study
ConclusionsR-PL and DAA THA had comparable short-term clinical and radiological outcomes along with similar complication rates. The R-PL group showed significantly lower Hb drop, rescue analgesic consumption and shorter LOS. This is a preliminary study and no strong recommendation can be provided. Further prospective randomized trials are requested to further investigate the cost-effectiveness of robotic surgery in THA.Level of evidenceLevel IV, case –control study. (Source: Journal of Orthopaedics and Traumatology)
Source: Journal of Orthopaedics and Traumatology - February 21, 2024 Category: Orthopaedics Source Type: research
Influence of cytochrome P450 2D6*10/*10 genotype on the risk for tramadol associated adverse effects: a retrospective cohort study
Conclusion: Among the different CYP2D6 genotypes, CYP2D6*10/*10 genotype carries the higher risk of tramadol related adverse events. Appreciating the frequency of this specific allele it seems prudent to pharmacogenetically screen patients considered for long term tramadol treatment for better tolerability and efficacy outcomes. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 19, 2024 Category: Drugs & Pharmacology Source Type: research
Uptake, translocation, and metabolization of amitriptyline, lidocaine, orphenadrine, and tramadol by cress and pea
Environ Sci Pollut Res Int. 2024 Feb 16. doi: 10.1007/s11356-024-32379-x. Online ahead of print.ABSTRACTThe uptake, translocation, and metabolization of four widely used drugs, amitriptyline, orphenadrine, lidocaine, and tramadol, were investigated in a laboratory study. Cress (Lepidium sativum L.) and pea (Pisum sativum L.) were employed as model plants. These plants were grown in tap water containing the selected pharmaceuticals at concentrations ranging from 0.010 to 10 mg L-1, whereby the latter concentration was employed for the (tentative) identification of drug-related metabolites formed within the plant. Thereby, m...
Source: Environmental Science and Pollution Research International - February 16, 2024 Category: Environmental Health Authors: Anna Detzlhofer Christian Grechhamer Lawrence Madikizela Markus Himmelsbach Franz Mlynek Wolfgang Buchberger Christian W Klampfl Source Type: research
Physical compatibility of colistin with analgesics during simulated Y-site administration
CONCLUSION: Colistin was found to be incompatible with ibuprofen and metamizole sodium formulations. It should also not be combined with morphine sulfate due to the significant differences in the pH value of the preparations. The colistin 0.67 mg/mL and 1.5 mg/mL infusion solutions were physically compatible with ketoprofen, tramadol hydrochloride, and paracetamol.PMID:38358317 | DOI:10.1093/ajhp/zxae035 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - February 15, 2024 Category: Drugs & Pharmacology Authors: Katarzyna Dettlaff Aleksandra Kowalska Aleksandra Gosty ńska Source Type: research
Physical compatibility of colistin with analgesics during simulated Y-site administration
CONCLUSION: Colistin was found to be incompatible with ibuprofen and metamizole sodium formulations. It should also not be combined with morphine sulfate due to the significant differences in the pH value of the preparations. The colistin 0.67 mg/mL and 1.5 mg/mL infusion solutions were physically compatible with ketoprofen, tramadol hydrochloride, and paracetamol.PMID:38358317 | DOI:10.1093/ajhp/zxae035 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - February 15, 2024 Category: Drugs & Pharmacology Authors: Katarzyna Dettlaff Aleksandra Kowalska Aleksandra Gosty ńska Source Type: research
