Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD

In conclusion, our results indicate a role of dietary FAs in the regulation of BA metabolism and progression of NAFLD. Interventions that aim to modify the composition of dietary FAs, rather than to regulate BA metabolism or signaling, may be more effective in the treatment of NAFLD.PMID:35858244 | DOI:10.1152/ajpendo.00052.2022

Source: Am J Physiol Endocri... - July 20, 2022 Category: Endocrinology Authors: Rodrigo Manjarin Kayla Dillard Morgan Coffin Gabriella V Hernandez Victoria A Smith Trista Noland-Liddell Tanvi R Gehani Hayden J Smart Kevin Wheeler Kimberly A Sprayberry Mark S Edwards Rob K Fanter Hunter Glanz Chad Immoos Tasha M Santiago-Rodriguez Jas Source Type: research