Contents
(Source: Translational Research)
Source: Translational Research - May 11, 2024 Category: Research Source Type: research
Masthead
(Source: Translational Research)
Source: Translational Research - May 11, 2024 Category: Research Source Type: research
Editorial Advisory Board
(Source: Translational Research)
Source: Translational Research - May 11, 2024 Category: Research Source Type: research
Author Guidelines
(Source: Translational Research)
Source: Translational Research - May 11, 2024 Category: Research Source Type: research
Information for Readers
(Source: Translational Research)
Source: Translational Research - May 11, 2024 Category: Research Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - May 11, 2024 Category: Research Source Type: research
Counteracting TGM2 by a Fibroin peptide ameliorated Adriamycin-induced nephropathy via regulation of lipid metabolism through PANX1-PPAR α/PANK1 pathway
In this study, we identified a novel short peptide (named YR-7, primary sequence ‘YEVEDYR’) from the natural Fibroin protein, and demonstrated that it significantly alleviated pathological renal changes in ADR-induced nephropathy. PANX1 was identified as the most notably upregulated component by RNA-sequencing. (Source: Translational Research)
Source: Translational Research - May 9, 2024 Category: Research Authors: Shan-Shan Li, Qiao-Juan Liu, Jia-Xin Bao, Meng-ting Lu, Bing-Quan Deng, Wen-Wen Li, Chang-Chun Cao Source Type: research
Immune cell distribution and DNA methylation signatures differ between tumor and stroma enriched compartment in pancreatic ductal adenocarcinoma
This study aims to investigate immune cell infiltration and epigenetic profiles in tumor cell enriched ( “Tumor”) and stroma cell enriched (“Stroma”) regions within human PDAC tissue samples. By comparing those regions, we identified 25,410 differentially methylated positions (DMPs) distributed across 6,963 unique genes. (Source: Translational Research)
Source: Translational Research - May 9, 2024 Category: Research Authors: Erwin Tomasich, Jakob M ühlbacher, Katharina Wöran, Teresa Hatziioannou, Merima Herac, Markus Kleinberger, Julia Maria Berger, Lea Katharina Dibon, Luzia Berchtold, Gerwin Heller, Elisabeth Sophie Bergen, Andrea Macher-Beer, Gerald Prager, Martin Schind Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - May 7, 2024 Category: Research Source Type: research
Masthead
(Source: Translational Research)
Source: Translational Research - May 7, 2024 Category: Research Source Type: research
Editorial Advisory Board
(Source: Translational Research)
Source: Translational Research - May 7, 2024 Category: Research Source Type: research
Author Guidelines
(Source: Translational Research)
Source: Translational Research - May 7, 2024 Category: Research Source Type: research
Information for Readers
(Source: Translational Research)
Source: Translational Research - May 7, 2024 Category: Research Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - May 7, 2024 Category: Research Source Type: research
Immune checkpoint activity exacerbate renal interstitial fibrosis progression by enhancing PD-L1 expression in renal tubular epithelial cells
Renal interstitial fibrosis (RIF) is often associated with inflammatory cell infiltration and no effective therapy. Programmed death cell-1 (PD-1) and its ligand PD-L1 were playing critical roles in T cell coinhibition and exhaustion, but the role in RIF is unclear. Here the data analyses of serum from 122 IgA nephrology (IgAN) patients showed that high level of soluble PD-1(sPD-1) was an independent risk factor for RIF and renal function progression. PD-L1 was also overexpressed in renal interstitial tissues from both IgAN patients with high level of sPD-1 and the unilateral ureteral obstruction (UUO) mouse. (Source: Translational Research)
Source: Translational Research - May 7, 2024 Category: Research Authors: Yuting Zhang, Xue Mi, Yunchao Zhang, Jipeng Li, Yunlong Qin, Peng He, Ya Zhao, Binxiao Su, Lijie He Source Type: research
