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Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications
Curr Drug Targets. 2024 Apr 26. doi: 10.2174/0113894501301747240417103321. Online ahead of print.ABSTRACTThe optimization of respiratory health is important, and one avenue for achieving this is through the application of both Pulmonary Drug Delivery System (PDDS) and Intranasal Delivery (IND). PDDS offers immediate delivery of medication to the respiratory system, providing advantages, such as sustained regional drug concentration, tunable drug release, extended duration of action, and enhanced patient compliance. IND, renowned for its non-invasive nature and swift onset of action, presents a promising path for advancemen...
Source: Current Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Wasan Alwahsh Shariza Sahudin Hatim Alkhatib Mohammad F Bostanudin Mohammad Alwahsh Source Type: research

Magnetomorph: The Future of Targeted Drug Delivery
Curr Drug Targets. 2024 Apr 18. doi: 10.2174/0113894501309729240414081308. Online ahead of print.NO ABSTRACTPMID:38639288 | DOI:10.2174/0113894501309729240414081308 (Source: Current Drug Targets)
Source: Current Drug Targets - April 19, 2024 Category: Drugs & Pharmacology Authors: Ashutosh Kumar Ghanshyam Das Gupta Manish Kumar Source Type: research

Transcending Molecules: Paving the Way from Lab to Life in Drug Transport Innovation
Curr Drug Targets. 2024 Apr 18. doi: 10.2174/0113894501305312240414073623. Online ahead of print.NO ABSTRACTPMID:38639289 | DOI:10.2174/0113894501305312240414073623 (Source: Current Drug Targets)
Source: Current Drug Targets - April 19, 2024 Category: Drugs & Pharmacology Authors: Abhishek Verma Abhishek Chauhan Ankit Awasthi Source Type: research

The Recent Advances in the Function and Mechanism of Caveolin-1 in Retinal Neovascularization
Curr Drug Targets. 2024 Apr 5. doi: 10.2174/0113894501310201240403065930. Online ahead of print.ABSTRACTRetinal neovascularization diseases have relatively high rates of evitable blindness. Abnormal retinal neovascularization is their main hallmark, which can damage the structure and function of the eye and lead to impaired vision. Caveolin-1 is a membrane protein that is expressed in many types of retinal cells and is involved in retinal neovascularization. This review presents a comprehensive analysis of global research on specific functions of caveolin-1 in retinal neovascularization. We believe that the mechanism of ac...
Source: Current Drug Targets - April 9, 2024 Category: Drugs & Pharmacology Authors: Rui Zhang Yalong Dang Source Type: research

Cisplatin-Based Combination Therapy for Enhanced Cancer Treatment
Curr Drug Targets. 2024 Apr 8. doi: 10.2174/0113894501294182240401060343. Online ahead of print.ABSTRACTCisplatin, a primary chemotherapeutic drug, is of great value in the realm of tumor treatment. However, its clinical efficacy is strictly hindered by issues, such as drug resistance, relapse, poor prognosis, and toxicity to normal tissue. Cisplatin-based combination therapy has garnered increasing attention in both preclinical and clinical cancer research for its ability to overcome resistance, reduce toxicity, and enhance anticancer effects. This review examines three primary co-administration strategies of cisplatin-ba...
Source: Current Drug Targets - April 9, 2024 Category: Drugs & Pharmacology Authors: Qi Li Siwei Chen Xiao Wang Jia Cai Hongwu Huang Shengsong Tang Dongxiu He Source Type: research