Vaccine-derived Yellow Fever in an immunocompromised patient on anti-CD20-antibody therapy and its treatment with Sofosbuvir
Yellow fever (YF) is a potentially lethal viral hemorrhagic fever transmitted to humans by Haemagogous and Aedes spp., (mainly Aedes aegypti). The risk of a YF infection for unvaccinated people during a two week stay in West Africa is about 50:100.000 and 5:100.000 in South America. Case fatality rates reach up to 40-60% in South America but are estimated at 20% in Africa [1] . The 17D live attenuated YF vaccine, which was developed in 1937 by Max Theiler, proved to be a highly effective method in preventing an outbreak of the symptomatic disease, but can also cause severe adverse reactions like YF vaccine-associated ne...
Source: International Journal of Infectious Diseases - March 21, 2024 Category: Infectious Diseases Authors: Tobias Weirauch, Gerrit Burger, D ániel Cadar, Martin Gabriel, Julia Koepsell, Gundolf Schüttfort, Philipp de Leuw, Markus Bickel, Maria J.G.T. Vehreschild, Timo Wolf, Nils Wetzstein Tags: Case Report Source Type: research
Yellow fever - An old foe with new developments
CONCLUSION: Health care providers in northern Australia should be aware of the risks of yellow fever and its introduction to northern Australia and be able to discuss vaccination status with their clients when needed.PMID:38506501 | DOI:10.1111/ajr.13101 (Source: The Australian Journal of Rural Health)
Source: The Australian Journal of Rural Health - March 20, 2024 Category: Rural Health Authors: Emily Grahn Jacqueline Picard Lars Henning Source Type: research
Yellow fever - An old foe with new developments
CONCLUSION: Health care providers in northern Australia should be aware of the risks of yellow fever and its introduction to northern Australia and be able to discuss vaccination status with their clients when needed.PMID:38506501 | DOI:10.1111/ajr.13101 (Source: The Australian Journal of Rural Health)
Source: The Australian Journal of Rural Health - March 20, 2024 Category: Rural Health Authors: Emily Grahn Jacqueline Picard Lars Henning Source Type: research
Live vaccinations in dermatology for immunosuppressed patients: a narrative review
Arch Dermatol Res. 2024 Mar 2;316(3):96. doi: 10.1007/s00403-024-02827-2.ABSTRACTGiven the higher susceptibility to infectious disease in patients receiving immunosuppressive therapies for inflammatory dermatologic conditions, immunization is important in this population. While live vaccines protect against life-threatening diseases, they can be harmful in immunosuppressed patients given the risk of replication of the attenuated pathogen and adverse reactions. The utilization of live vaccines in immunosuppressed patients depends on multiple factors such as the vaccine and therapy regimen. To provide an overview of evidence...
Source: Herpes - March 2, 2024 Category: Infectious Diseases Authors: Divya M Shan Rithi J Chandy Andrew Fultz John W Sanders Steven R Feldman Source Type: research
Live vaccinations in dermatology for immunosuppressed patients: a narrative review
Arch Dermatol Res. 2024 Mar 2;316(3):96. doi: 10.1007/s00403-024-02827-2.ABSTRACTGiven the higher susceptibility to infectious disease in patients receiving immunosuppressive therapies for inflammatory dermatologic conditions, immunization is important in this population. While live vaccines protect against life-threatening diseases, they can be harmful in immunosuppressed patients given the risk of replication of the attenuated pathogen and adverse reactions. The utilization of live vaccines in immunosuppressed patients depends on multiple factors such as the vaccine and therapy regimen. To provide an overview of evidence...
Source: Herpes - March 2, 2024 Category: Infectious Diseases Authors: Divya M Shan Rithi J Chandy Andrew Fultz John W Sanders Steven R Feldman Source Type: research
Live vaccinations in dermatology for immunosuppressed patients: a narrative review
AbstractGiven the higher susceptibility to infectious disease in patients receiving immunosuppressive therapies for inflammatory dermatologic conditions, immunization is important in this population. While live vaccines protect against life-threatening diseases, they can be harmful in immunosuppressed patients given the risk of replication of the attenuated pathogen and adverse reactions. The utilization of live vaccines in immunosuppressed patients depends on multiple factors such as the vaccine and therapy regimen. To provide an overview of evidence-based recommendations for the use of live vaccines in patients receiving...
Source: Archives of Dermatological Research - March 2, 2024 Category: Dermatology Source Type: research
Trained immunity-inducing vaccines: Harnessing innate memory for vaccine design and delivery
Clin Immunol. 2024 Feb 9;261:109930. doi: 10.1016/j.clim.2024.109930. Online ahead of print.ABSTRACTWhile the efficacy of many current vaccines is well-established, various factors can diminish their effectiveness, particularly in vulnerable groups. Amidst emerging pandemic threats, enhancing vaccine responses is critical. Our review synthesizes insights from immunology and epidemiology, focusing on the concept of trained immunity (TRIM) and the non-specific effects (NSEs) of vaccines that confer heterologous protection. We elucidate the mechanisms driving TRIM, emphasizing its regulation through metabolic and epigenetic r...
Source: Clinical Immunology - February 11, 2024 Category: Allergy & Immunology Authors: Ilayda Baydemir Elisabeth A Dulfer Mihai G Netea Jorge Dom ínguez-Andrés Source Type: research
Safety of the yellow fever vaccine in people living with HIV: a longitudinal study exploring post-vaccination viremia and hematological and liver kinetics
CONCLUSIONS: 17DD was safe and well-tolerated in PLWH with CD4 ≥ 200 cells/µL. Post-vaccination viremia was more frequent in PLWH than in controls. Transient and self-limited decreases in lymphocytes and neutrophils occurred early after vaccination. 17DD viremia was associated with lower lymphocytes and platelets nadir after vaccination. We did not observe elevations in ALT after 17DD vaccination.PMID:38341187 | DOI:10.1016/j.bjid.2024.103719 (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - February 10, 2024 Category: Infectious Diseases Authors: Edwiges Motta Luiz Ant ônio B Camacho Ana Bispo de Filippis Marcellus Costa Luciana Pedro Sandra W Cardoso Marta Cristina de Oliveira Souza Ygara da Silva Mendes Beatriz Grinsztejn Lara E Coelho Source Type: research
Safety of the yellow fever vaccine in people living with HIV: a longitudinal study exploring post-vaccination viremia and hematological and liver kinetics
CONCLUSIONS: 17DD was safe and well-tolerated in PLWH with CD4 ≥ 200 cells/µL. Post-vaccination viremia was more frequent in PLWH than in controls. Transient and self-limited decreases in lymphocytes and neutrophils occurred early after vaccination. 17DD viremia was associated with lower lymphocytes and platelets nadir after vaccination. We did not observe elevations in ALT after 17DD vaccination.PMID:38341187 | DOI:10.1016/j.bjid.2024.103719 (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - February 10, 2024 Category: Infectious Diseases Authors: Edwiges Motta Luiz Ant ônio B Camacho Ana Bispo de Filippis Marcellus Costa Luciana Pedro Sandra W Cardoso Marta Cristina de Oliveira Souza Ygara da Silva Mendes Beatriz Grinsztejn Lara E Coelho Source Type: research
Safety of the yellow fever vaccine in people living with HIV: a longitudinal study exploring post-vaccination viremia and hematological and liver kinetics
CONCLUSIONS: 17DD was safe and well-tolerated in PLWH with CD4 ≥ 200 cells/µL. Post-vaccination viremia was more frequent in PLWH than in controls. Transient and self-limited decreases in lymphocytes and neutrophils occurred early after vaccination. 17DD viremia was associated with lower lymphocytes and platelets nadir after vaccination. We did not observe elevations in ALT after 17DD vaccination.PMID:38341187 | DOI:10.1016/j.bjid.2024.103719 (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - February 10, 2024 Category: Infectious Diseases Authors: Edwiges Motta Luiz Ant ônio B Camacho Ana Bispo de Filippis Marcellus Costa Luciana Pedro Sandra W Cardoso Marta Cristina de Oliveira Souza Ygara da Silva Mendes Beatriz Grinsztejn Lara E Coelho Source Type: research
Vaccination against yellow fever in fractionated doses without a previous skin test and egg anaphylaxis
Yellow fever is a public health problem with a high morbimortality. The vaccine against yellow fever (YFV) is effective but represents a risk for patients with egg allergy because of its ovalbumin content. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Raquel Pitchon, Adriana Pitchon Source Type: research
Yellow fever virus infection in human hepatocyte cells triggers an imbalance in redox homeostasis with increased reactive oxygen species production, oxidative stress, and decreased antioxidant enzymes
Free Radic Biol Med. 2024 Mar;213:266-273. doi: 10.1016/j.freeradbiomed.2024.01.042. Epub 2024 Jan 24.ABSTRACTYellow fever (YF) presents a wide spectrum of severity, with clinical manifestations in humans ranging from febrile and self-limited to fatal cases. Although YF is an old disease for which an effective and safe vaccine exists, little is known about the viral- and host-specific mechanisms that contribute to liver pathology. Several studies have demonstrated that oxidative stress triggered by viral infections contributes to pathogenesis. We evaluated whether yellow fever virus (YFV), when infecting human hepatocytes ...
Source: Free Radical Biology and Medicine - January 26, 2024 Category: Biology Authors: Ariane Coelho Ferraz Mar ília Bueno da Silva Menegatto Rafaela Lameira Souza Lima Oluwashola Samuel Ola-Olub Daniela Caldeira Costa Jos é Carlos de Magalhães Izabela Maur ício Rezende Angelle Desiree LaBeaud Thomas P Monath Pedro Augusto Alves Andr é Source Type: research
Phylogenetic analysis reveals a new introduction of Yellow Fever virus in S ão Paulo State, Brazil, 2023
Acta Trop. 2023 Dec 30:107110. doi: 10.1016/j.actatropica.2023.107110. Online ahead of print.ABSTRACTYellow Fever (YF) is a viral arbovirosis of Public Health importance. In Brazil, surveillance is focused mainly on detecting epizootic events of Platyrrhini. Herein, we compared the detection and phylogenetic analysis of YF virus in two neotropical primates (NTP), a Callithrix detected in the previous epidemic period (2016-2020), and a Callicebus nigrifons, showing a new introduction of YF in 2023. This paper illustrates the importance of joint actions of laboratory and field teams to ensure quick response to Public Health ...
Source: Acta Tropica - January 1, 2024 Category: Infectious Diseases Authors: Nat ália C C de A Fernandes Mariana Sequetin Cunha Pedro Enrique Navas Suarez Eduardo Ferreira Machado Jamile Macedo Garcia Ana Carolina Souza Ramos De Carvalho Ketlyn Bolsachini Figueiredo Rodrigo Albergaria Ressio Patricia Sayuri Silvestre Matsumoto Le Source Type: research
Phylogenetic analysis reveals a new introduction of Yellow Fever virus in S ão Paulo State, Brazil, 2023
Acta Trop. 2023 Dec 30;251:107110. doi: 10.1016/j.actatropica.2023.107110. Online ahead of print.ABSTRACTYellow Fever (YF) is a viral arbovirosis of Public Health importance. In Brazil, surveillance is focused mainly on detecting epizootic events of Platyrrhini. Herein, we compared the detection and phylogenetic analysis of YF virus in two neotropical primates (NTP), a Callithrix detected in the previous epidemic period (2016-2020), and a Callicebus nigrifons, showing a new introduction of YF in 2023. This paper illustrates the importance of joint actions of laboratory and field teams to ensure quick response to Public Hea...
Source: Acta Tropica - January 1, 2024 Category: Infectious Diseases Authors: Nat ália C C de A Fernandes Mariana Sequetin Cunha Pedro Enrique Navas Suarez Eduardo Ferreira Machado Jamile Macedo Garcia Ana Carolina Souza Ramos De Carvalho Ketlyn Bolsachini Figueiredo Rodrigo Albergaria Ressio Patricia Sayuri Silvestre Matsumoto Le Source Type: research
