Viruses, Vol. 14, Pages 2231: Neotropical Sylvatic Mosquitoes and Aedes aegypti Are Not Competent to Transmit 17DD Attenuated Yellow Fever Virus from Vaccinated Viremic New World Non-Human Primates
os da Silva Freire
Jerônimo Augusto Fonseca Alencar
Ricardo Lourenco-de-Oliveira
Beside humans, thousands of non-human primates (NHPs) died during the recent outbreak caused by the yellow fever virus (YFV) in Brazil. Vaccination of NHPs against YFV with the YF 17DD attenuated virus has emerged as a public health strategy, as it would reduce sylvatic transmission while also preserving endangered susceptible species. The hypothesis of establishing an uncontrolled transmission of this attenuated virus in nature was raised. We assessed vector competence of four sylvatic mosquito species, Haemagogus leucocelaenus, Haem...
Source: Viruses - October 11, 2022 Category: Virology Authors: Rafaella Moraes de Miranda Rosilainy Surubi Fernandes Andr é Tavares da Silva-Fernandes Anielly Ferreira-de-Brito Silvia Bahadian Moreira Renata Carvalho Pereira Ygara da Silva Mendes Sheila Maria Barbosa de Lima Alcides Pissinatti Marcos da Silva Freire Tags: Article Source Type: research
Transfusion-transmitted arboviruses: Update and systematic review
DiscussionIn the last 20 years, the number of published cases of transfusion-transmitted arboviruses increased notably, implicating new arboviruses. In addition, a significant number of arboviruses that may pose a threat to transfusion safety were detected. In the coming years, it is expected that transmission of arboviruses will continue to expand globally. It is therefore essential that all responsible agencies prepare for this potential threat to transfusion safety. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - October 6, 2022 Category: Tropical Medicine Authors: Ángel Giménez-Richarte Source Type: research
Zika virus NS2B-NS3 protease: Quantum chemical properties insights for designing inhibitory peptides
CONCLUSION: Furthermore, it was also noted that high electron affinity, related to electrophilicity index, promoted electron accepting characteristic, which was important to improve the biological activity of the peptides. A larger compound series have to studied in order to access features more precisely. However, these results have paramount importance to guide future effort in this extremely-need health area.PMID:36121092 | DOI:10.2174/0929866529666220919143316 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - September 19, 2022 Category: Biochemistry Authors: Jo ão Vitor Silva D ébora Savino Mario Hiroyuki Hirata Gl áucio Monteiro Ferreira Jeanine Giarolla Source Type: research
Occurrence of yellow fever outbreaks in a partially vaccinated population: An analysis of the effective reproduction number
ConclusionThe outbreaks in multiple parts of the state and the estimatedRe values raise concern since the state population was partially vaccinated. Heterogeneity in vaccination coverage may have been associated with the occurrence of outbreaks in the first period, while the subsequent intense vaccination campaign may have determined lowerRe values in the second period. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - September 15, 2022 Category: Tropical Medicine Authors: Fernanda Cristina da Silva Lopes Ferreira Source Type: research
Travelers and travel vaccines at six health care systems in the Vaccine Safety Datalink
CONCLUSIONS: Through the EHR information from almost a million travelers, a departure date and duration of travel were successfully captured for the majority of travelers with corresponding health care utilization data. Time after vaccination and prior to departure can potentially be used in the future to compare travelers who receive travel vaccines with travelers who do not receive travel vaccines when looking at adverse events of interest after vaccination.PMID:36064668 | DOI:10.1016/j.vaccine.2022.08.023 (Source: Vaccine)
Source: Vaccine - September 5, 2022 Category: Allergy & Immunology Authors: Bruno Lewin Lei Qian Runxin Huang Lina S Sy Kristin Goddard Allison L Naleway Malini DeSilva Matthew F Daley Michael M McNeil Lisa A Jackson Steven J Jacobsen Source Type: research
Travelers and travel vaccines at six health care systems in the Vaccine Safety Datalink
CONCLUSIONS: Through the EHR information from almost a million travelers, a departure date and duration of travel were successfully captured for the majority of travelers with corresponding health care utilization data. Time after vaccination and prior to departure can potentially be used in the future to compare travelers who receive travel vaccines with travelers who do not receive travel vaccines when looking at adverse events of interest after vaccination.PMID:36064668 | DOI:10.1016/j.vaccine.2022.08.023 (Source: Vaccine)
Source: Vaccine - September 5, 2022 Category: Allergy & Immunology Authors: Bruno Lewin Lei Qian Runxin Huang Lina S Sy Kristin Goddard Allison L Naleway Malini DeSilva Matthew F Daley Michael M McNeil Lisa A Jackson Steven J Jacobsen Source Type: research
Phenotypic and genetic characterization of a next generation live-attenuated yellow fever vaccine candidate
Vaccine. 2022 Aug 23:S0264-410X(22)00939-2. doi: 10.1016/j.vaccine.2022.07.043. Online ahead of print.ABSTRACTWe assessed the genetic and phenotypic characteristics of a yellow fever vaccine candidate, which was cloned from a YF-VAX substrain selected for growth in Vero cells (vYF-247), during the manufacturing process from the master seed lot (MSL) and working seed lot (WSL) through to the drug substance (DS) stage. There were nine minor nucleotide variants observed from the MSL to the DS stage, of which five led to amino acid changes. The variant positions were, however, not known risks for any virulence modification. vY...
Source: Vaccine - August 26, 2022 Category: Allergy & Immunology Authors: Raphael Esson Emanuel Rodrigues De Sousa Loic Benair Nicolas Devard Damien Soulet Audrey Gillet Isabelle Bassard Stephanie Falque Audrey Chareyre Morgane Marmin Yves Girerd-Chambaz Carine Logvinoff Martha Erika Navarro Sanchez Source Type: research
Anti-NMDA receptor encephalitis and vaccination: A disproportionality analysis
In this study, we aimed to investigate the possible existence of pharmacovigilance signals relating to a link between vaccination and the occurrence of anti-NMDAR encephalitis. We performed a case/non-case study using data from the World Health Organization pharmacovigilance database (VigiBase) up to 31 December 2021. All individual case study reports (ICSRs) linked to a vaccine and coded with the MedDRA Lower Level Term (LLT) “anti-NMDA receptor encephalitis” were analysed. We calculated the Reporting Odds Ratio (ROR) and 95% Confidence Interval (CI) for each type of vaccine. A total of 29,758,737 ICSRs were registere...
Source: Frontiers in Pharmacology - August 17, 2022 Category: Drugs & Pharmacology Source Type: research
Zoonoses and gold mining: A cross-sectional study to assess yellow fever immunization, Q fever, leptospirosis and leishmaniasis among the population working on illegal mining camps in French Guiana
DiscussionThese unique data shed new light on the transmission cycles of zoonoses still poorly understood in the region. They support the existence of a wild cycle of leptospirosis but not of Q fever. Leishmaniasis prevalence was high because of life conditions and tree felling. High yellow fever vaccine coverage was reassuring in this endemic area. In the era of global health, special attention must be paid to these vulnerable populations in direct contact with the tropical ecosystem and away from the health care system. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - August 15, 2022 Category: Tropical Medicine Authors: Maylis Douine Source Type: research
Viruses, Vol. 14, Pages 1645: Mapping and Validation of Peptides Differentially Recognized by Antibodies from the Serum of Yellow Fever Virus-Infected or 17DD-Vaccinated Patients
In this study, peptides were designed and subjected to microarray procedures with sera collected from individuals infected by WT-YFV and 17DD–YFV of YFV during the Brazilian outbreak of YFV in 2017/2018. From 222 screened peptides, around ten could potentially integrate serological approaches aiming to differentiate vaccinated individuals from naturally infected individuals. Among those peptides, one was synthesized and validated through ELISA. (Source: Viruses)
Source: Viruses - July 27, 2022 Category: Virology Authors: Eneida Santos Oliveira Naiara Clemente Tavares Stella Garcia Colombarolli Izabella Cristina Andrade Batista Camila Sales Nascimento Philip Louis Felgner Rafael Ramiro de Assis Carlos Eduardo Calzavara-Silva Tags: Article Source Type: research
An immunologist's guide to immunosenescence and its treatment
Expert Rev Clin Immunol. 2022 Jul 25. doi: 10.1080/1744666X.2022.2106217. Online ahead of print.ABSTRACTINTRODUCTION: : The ageing process causes several changes in the immune system, although immune ageing is strongly influenced by individual immunological history, as well as genetic and environmental factors leading to inter-individual variability.AREAS COVERED: : Here, we focused on the biological and clinical meaning of immunosenescence. Data on SARS-CoV-2 and Yellow Fever vaccine have demonstrated the clinical relevance of immunosenescence, while inconsistent results, obtained from longitudinal studies aimed at lookin...
Source: Expert Review of Clinical Immunology - July 25, 2022 Category: Allergy & Immunology Authors: Calogero Caruso Mattia Emanuela Ligotti Giulia Accardi Anna Aiello Giuseppina Candore Source Type: research
The Addis Declaration on Immunization: A binding reminder of the political support needed to achieve universal immunization in Africa
Vaccine. 2022 Jul 21:S0264-410X(22)00843-X. doi: 10.1016/j.vaccine.2022.06.073. Online ahead of print.ABSTRACTWhile African countries have improved access to immunization since the start of the millennium, progress has stagnated in the last few years. One in five African children is not vaccinated with life-saving vaccines, and recent outbreaks of vaccine-preventable diseases (VPDs) including yellow fever, measles, and meningitis, among others point to gaps in immunization coverage as well as disease surveillance. In 2017, African Heads of State endorsed the Addis Declaration on Immunization (ADI) at the 28th African Union...
Source: Vaccine - July 25, 2022 Category: Allergy & Immunology Authors: Richard M Mihigo Joseph C Okeibunor Fahmy Karmal Helena O'Malley Natasha Godinho Linda Okero Alain N Poy Ouma Onyango Niamh Fitzgerald Source Type: research
An immunologist's guide to immunosenescence and its treatment
Expert Rev Clin Immunol. 2022 Jul 25. doi: 10.1080/1744666X.2022.2106217. Online ahead of print.ABSTRACTINTRODUCTION: : The ageing process causes several changes in the immune system, although immune ageing is strongly influenced by individual immunological history, as well as genetic and environmental factors leading to inter-individual variability.AREAS COVERED: : Here, we focused on the biological and clinical meaning of immunosenescence. Data on SARS-CoV-2 and Yellow Fever vaccine have demonstrated the clinical relevance of immunosenescence, while inconsistent results, obtained from longitudinal studies aimed at lookin...
Source: Expert Review of Clinical Immunology - July 25, 2022 Category: Allergy & Immunology Authors: Calogero Caruso Mattia Emanuela Ligotti Giulia Accardi Anna Aiello Giuseppina Candore Source Type: research
