Comparative Infections of Zika, Dengue, and Yellow Fever Viruses in Human Cytotrophoblast-Derived Cells Suggest a Gating Role for the Cytotrophoblast in Zika Virus Placental Invasion
Microbiol Spectr. 2023 May 25:e0063023. doi: 10.1128/spectrum.00630-23. Online ahead of print.ABSTRACTThe Zika virus (ZIKV) is teratogenic and considered a TORCH pathogen (toxoplasmosis [Toxoplasma gondii], rubella, cytomegalovirus, herpes simplex virus [HSV], and other microorganisms capable of crossing the blood-placenta barrier). In contrast, the related flavivirus dengue virus (DENV) and the attenuated yellow fever virus vaccine strain (YFV-17D) are not. Understanding the mechanisms used by ZIKV to cross the placenta is necessary. In this work, parallel infections with ZIKV of African and Asian lineages, DENV, and YFV-...
Source: Herpes - May 25, 2023 Category: Infectious Diseases Authors: Mercedes Viettri Gerson Caraballo Maria Elena Sanchez Aurora Espejel-Nu ñez Abigail Betanzos Vianney Ortiz-Navarrete Guadalupe Estrada-Gutierrez Porfirio Nava Juan E Ludert Source Type: research
Low Vaccine Coverage and Factors Associated with Incomplete Childhood Immunization in Racial/Ethnic Minorities and Rural Groups, Central Brazil
Vaccines (Basel). 2023 Apr 13;11(4):838. doi: 10.3390/vaccines11040838.ABSTRACTDiscrimination and limited access to healthcare services in remote areas can affect vaccination coverage. Therefore, this study aimed to estimate vaccination coverage for children living in quilombola communities and rural settlements in the central region of Brazil during their first year of life and to analyze the factors associated with incomplete vaccination. An analytical cross-sectional study was conducted on children born between 2015 and 2017. The percentage of children who received all vaccines recommended by the National Immunization P...
Source: Rural Remote Health - April 28, 2023 Category: Rural Health Authors: Juliana de Oliveira Roque E Lima Val éria Pagotto B árbara Souza Rocha Paulo S érgio Scalize Rafael Alves Guimar ães M árcio Dias de Lima Leandro Nascimento da Silva Michele Dias da Silva Oliveira Winny Éveny Alves Moura Sheila Ara újo Teles Claci Source Type: research
Low Vaccine Coverage and Factors Associated with Incomplete Childhood Immunization in Racial/Ethnic Minorities and Rural Groups, Central Brazil
Vaccines (Basel). 2023 Apr 13;11(4):838. doi: 10.3390/vaccines11040838.ABSTRACTDiscrimination and limited access to healthcare services in remote areas can affect vaccination coverage. Therefore, this study aimed to estimate vaccination coverage for children living in quilombola communities and rural settlements in the central region of Brazil during their first year of life and to analyze the factors associated with incomplete vaccination. An analytical cross-sectional study was conducted on children born between 2015 and 2017. The percentage of children who received all vaccines recommended by the National Immunization P...
Source: Rural Remote Health - April 28, 2023 Category: Rural Health Authors: Juliana de Oliveira Roque E Lima Val éria Pagotto B árbara Souza Rocha Paulo S érgio Scalize Rafael Alves Guimar ães M árcio Dias de Lima Leandro Nascimento da Silva Michele Dias da Silva Oliveira Winny Éveny Alves Moura Sheila Ara újo Teles Claci Source Type: research
Low Vaccine Coverage and Factors Associated with Incomplete Childhood Immunization in Racial/Ethnic Minorities and Rural Groups, Central Brazil
Vaccines (Basel). 2023 Apr 13;11(4):838. doi: 10.3390/vaccines11040838.ABSTRACTDiscrimination and limited access to healthcare services in remote areas can affect vaccination coverage. Therefore, this study aimed to estimate vaccination coverage for children living in quilombola communities and rural settlements in the central region of Brazil during their first year of life and to analyze the factors associated with incomplete vaccination. An analytical cross-sectional study was conducted on children born between 2015 and 2017. The percentage of children who received all vaccines recommended by the National Immunization P...
Source: Rural Remote Health - April 28, 2023 Category: Rural Health Authors: Juliana de Oliveira Roque E Lima Val éria Pagotto B árbara Souza Rocha Paulo S érgio Scalize Rafael Alves Guimar ães M árcio Dias de Lima Leandro Nascimento da Silva Michele Dias da Silva Oliveira Winny Éveny Alves Moura Sheila Ara újo Teles Claci Source Type: research
Viruses, Vol. 15, Pages 860: A Perspective on Current Flavivirus Vaccine Development: A Brief Review
urg
The flavivirus genus contains several clinically important pathogens that account for tremendous global suffering. Primarily transmitted by mosquitos or ticks, these viruses can cause severe and potentially fatal diseases ranging from hemorrhagic fevers to encephalitis. The extensive global burden is predominantly caused by six flaviviruses: dengue, Zika, West Nile, yellow fever, Japanese encephalitis and tick-borne encephalitis. Several vaccines have been developed, and many more are currently being tested in clinical trials. However, flavivirus vaccine development is still confronted with many shortcomings and ch...
Source: Viruses - March 28, 2023 Category: Virology Authors: Sudip Kumar Dutta Thomas Langenburg Tags: Review Source Type: research
Pan-Yellow Fever Virus Detection and Lineage Assignment by Real-Time RT-PCR and Amplicon Sequencing
J Virol Methods. 2023 Mar 25:114717. doi: 10.1016/j.jviromet.2023.114717. Online ahead of print.ABSTRACTYellow fever disease is a viral zoonosis that may result in a severe hemorrhagic disease. A safe and effective vaccine used in mass immunization campaigns has allowed control and mitigation against explosive outbreaks in endemic areas. Since the 1960's, re-emergent of the yellow fever virus has been observed. The timely implementation of control measures, to avoid or contain an ongoing outbreak requires rapid specific viral detection methods. Here a novel molecular assay, expected to detect all known yellow fever virus s...
Source: Journal of Virological Methods - March 27, 2023 Category: Virology Authors: Giovanni Faggioni Riccardo De Santis Filippo Moramarco Mario Di Donato Angelo De Domenico Filippo Molinari Giancarlo Petralito Claudia Fortuna Giulietta Venturi Giovanni Rezza Florigio Lista Source Type: research
Pan-Yellow Fever Virus Detection and Lineage Assignment by Real-Time RT-PCR and Amplicon Sequencing
J Virol Methods. 2023 Mar 25:114717. doi: 10.1016/j.jviromet.2023.114717. Online ahead of print.ABSTRACTYellow fever disease is a viral zoonosis that may result in a severe hemorrhagic disease. A safe and effective vaccine used in mass immunization campaigns has allowed control and mitigation against explosive outbreaks in endemic areas. Since the 1960's, re-emergent of the yellow fever virus has been observed. The timely implementation of control measures, to avoid or contain an ongoing outbreak requires rapid specific viral detection methods. Here a novel molecular assay, expected to detect all known yellow fever virus s...
Source: Journal of Virological Methods - March 27, 2023 Category: Virology Authors: Giovanni Faggioni Riccardo De Santis Filippo Moramarco Mario Di Donato Angelo De Domenico Filippo Molinari Giancarlo Petralito Claudia Fortuna Giulietta Venturi Giovanni Rezza Florigio Lista Source Type: research
Pan-Yellow Fever Virus Detection and Lineage Assignment by Real-Time RT-PCR and Amplicon Sequencing
J Virol Methods. 2023 Mar 25:114717. doi: 10.1016/j.jviromet.2023.114717. Online ahead of print.ABSTRACTYellow fever disease is a viral zoonosis that may result in a severe hemorrhagic disease. A safe and effective vaccine used in mass immunization campaigns has allowed control and mitigation against explosive outbreaks in endemic areas. Since the 1960's, re-emergent of the yellow fever virus has been observed. The timely implementation of control measures, to avoid or contain an ongoing outbreak requires rapid specific viral detection methods. Here a novel molecular assay, expected to detect all known yellow fever virus s...
Source: Journal of Virological Methods - March 27, 2023 Category: Virology Authors: Giovanni Faggioni Riccardo De Santis Filippo Moramarco Mario Di Donato Angelo De Domenico Filippo Molinari Giancarlo Petralito Claudia Fortuna Giulietta Venturi Giovanni Rezza Florigio Lista Source Type: research
Durability of neutralizing antibodies against yellow fever virus after vaccination in healthy adults
In conclusion, our study confirms on a larger scale that, in healthy adults, neutralizing antibodies may persist as long as 47 years after a single yellow fever vaccines dose.PMID:36967285 | DOI:10.1016/j.vaccine.2023.03.022 (Source: Vaccine)
Source: Vaccine - March 26, 2023 Category: Allergy & Immunology Authors: Riccardo De Santis Giovanni Faggioni Alessandra Amoroso Andrea Ciammaruconi Alice Pomponi Maria Stella Lia Donatella Amatore Filippo Molinari Giancarlo Petralito Paola Stefanelli Giovanni Rezza Florigio Lista Source Type: research
Durability of neutralizing antibodies against yellow fever virus after vaccination in healthy adults
In conclusion, our study confirms on a larger scale that, in healthy adults, neutralizing antibodies may persist as long as 47 years after a single yellow fever vaccines dose.PMID:36967285 | DOI:10.1016/j.vaccine.2023.03.022 (Source: Vaccine)
Source: Vaccine - March 26, 2023 Category: Allergy & Immunology Authors: Riccardo De Santis Giovanni Faggioni Alessandra Amoroso Andrea Ciammaruconi Alice Pomponi Maria Stella Lia Donatella Amatore Filippo Molinari Giancarlo Petralito Paola Stefanelli Giovanni Rezza Florigio Lista Source Type: research
Durability of neutralizing antibodies against yellow fever virus after vaccination in healthy adults
In conclusion, our study confirms on a larger scale that, in healthy adults, neutralizing antibodies may persist as long as 47 years after a single yellow fever vaccines dose.PMID:36967285 | DOI:10.1016/j.vaccine.2023.03.022 (Source: Vaccine)
Source: Vaccine - March 26, 2023 Category: Allergy & Immunology Authors: Riccardo De Santis Giovanni Faggioni Alessandra Amoroso Andrea Ciammaruconi Alice Pomponi Maria Stella Lia Donatella Amatore Filippo Molinari Giancarlo Petralito Paola Stefanelli Giovanni Rezza Florigio Lista Source Type: research
Viruses, Vol. 15, Pages 813: Recent Advancements in Mosquito-Borne Flavivirus Vaccine Development
Qian
Lately, the global incidence of flavivirus infection has been increasing dramatically and presents formidable challenges for public health systems around the world. Most clinically significant flaviviruses are mosquito-borne, such as the four serotypes of dengue virus, Zika virus, West Nile virus, Japanese encephalitis virus and yellow fever virus. Until now, no effective antiflaviviral drugs are available to fight flaviviral infection; thus, a highly immunogenic vaccine would be the most effective weapon to control the diseases. In recent years, flavivirus vaccine research has made major breakthroughs with sever...
Source: Viruses - March 23, 2023 Category: Virology Authors: Bingan Wu Zhongtian Qi Xijing Qian Tags: Review Source Type: research
VIGET: A web portal for study of vaccine-induced host responses based on Reactome pathways and ImmPort data
Host responses to vaccines are complex but important to investigate. To facilitate the study, we have developed a tool called Vaccine Induced Gene Expression Analysis Tool (VIGET), with the aim to provide an interactive online tool for users to efficiently and robustly analyze the host immune response gene expression data collected in the ImmPort/GEO databases. VIGET allows users to select vaccines, choose ImmPort studies, set up analysis models by choosing confounding variables and two groups of samples having different vaccination times, and then perform differential expression analysis to select genes for pathway enrich...
Source: Frontiers in Immunology - March 21, 2023 Category: Allergy & Immunology Source Type: research
Immune response to co-administration of measles, mumps, and rubella (MMR), and yellow fever vaccines: a randomized non-inferiority trial among one-year-old children in Argentina
In yellow fever (YF) endemic areas, measles, mumps, and rubella (MMR), and YF vaccines are often co-administered in childhood vaccination schedules. Because these are live vaccines, we assessed potential immun... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - March 17, 2023 Category: Infectious Diseases Authors: Carla Vizzotti, Jennifer B. Harris, Anal ía Aquino, Carolina Rancaño, Cristian Biscayart, Romina Bonaventura, Andrea Pontoriero, Elsa Baumeister, Maria Cecilia Freire, Mirta Magariños, Blanca Duarte, Gavin Grant, Susan Reef, Janeen Laven, Kathleen A. W Tags: Research Source Type: research
Viruses, Vol. 15, Pages 757: Yellow Fever Virus Maintained by Sabethes Mosquitoes during the Dry Season in Cerrado, a Semiarid Region of Brazil, in 2021
P. Sevá
Andrea Oliveira Dias Temponi
Fernando Maria Magalhães
Agna Soares da Silva Menezes
Bartolomeu Teixeira Lopes
Hermes P. Almeida
Ana Lúcia Pedroso
Giovani Pontel Gonçalves
Danielle Costa Capistrano Chaves
Givaldo Gomes de Menezes
Sofía Bernal-Valle
Nicolas FD Müller
Luis Janssen
Edmilson dos Santos
Maria A. Mares-Guia
George R. Albuquerque
Alessandro PM Romano
Ana C. Franco
Bergmann M. Ribeiro
Paulo M. Roehe
Ricardo Lourenço-de-Oliveira
Filipe Vieira Santos de Abreu
In recent decades, waves of yellow fever virus (YFV) from the Amazon Rainforest have spread and cau...
Source: Viruses - March 15, 2023 Category: Virology Authors: Cirilo H. de Oliveira Miguel S. Andrade Fabr ício S. Campos Jader da C. Cardoso Maria Eduarda Gon çalves-dos-Santos Ramon Silva Oliveira Sandy Micaele Aquino-Teixeira Aline AS Campos Marco AB Almeida Danilo Simonini-Teixeira Anai á da P. Sevá Andrea O Tags: Article Source Type: research
