Viruses, Vol. 15, Pages 860: A Perspective on Current Flavivirus Vaccine Development: A Brief Review
Viruses, Vol. 15, Pages 860: A Perspective on Current Flavivirus Vaccine Development: A Brief Review
Viruses doi: 10.3390/v15040860
Authors:
Sudip Kumar Dutta
Thomas Langenburg
The flavivirus genus contains several clinically important pathogens that account for tremendous global suffering. Primarily transmitted by mosquitos or ticks, these viruses can cause severe and potentially fatal diseases ranging from hemorrhagic fevers to encephalitis. The extensive global burden is predominantly caused by six flaviviruses: dengue, Zika, West Nile, yellow fever, Japanese encephalitis and tick-borne encephalitis. Several vaccines have been developed, and many more are currently being tested in clinical trials. However, flavivirus vaccine development is still confronted with many shortcomings and challenges. With the use of the existing literature, we have studied these hurdles as well as the signs of progress made in flavivirus vaccinology in the context of future development strategies. Moreover, all current licensed and phase-trial flavivirus vaccines have been gathered and discussed based on their vaccine type. Furthermore, potentially relevant vaccine types without any candidates in clinical testing are explored in this review as well. Over the past decades, several modern vaccine types have expanded the field of vaccinology, potentially providing alternative solutions for flavivirus vaccines. These vaccine types offer different development strategies as opposed to tradit...
Source: Viruses - Category: Virology Authors: Sudip Kumar Dutta Thomas Langenburg Tags: Review Source Type: research
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