Zika virus NS2B-NS3 protease: Quantum chemical properties insights for designing inhibitory peptides

CONCLUSION: Furthermore, it was also noted that high electron affinity, related to electrophilicity index, promoted electron accepting characteristic, which was important to improve the biological activity of the peptides. A larger compound series have to studied in order to access features more precisely. However, these results have paramount importance to guide future effort in this extremely-need health area.PMID:36121092 | DOI:10.2174/0929866529666220919143316

Source: Protein and Peptide Letters - September 19, 2022 Category: Biochemistry Authors: Jo ão Vitor Silva D ébora Savino Mario Hiroyuki Hirata Gl áucio Monteiro Ferreira Jeanine Giarolla Source Type: research